ALPHA CRYSTALLIN

阿尔法水晶蛋白

• 批准号: 8168603
• 负责人: Jonathan Alan King
• 金额: $ 0.43万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-15 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168603
• 关键词: Cells; Complex; Computer Retrieval of Information on Scientific Projects Database; Crying; Crystallins; Funding; Grant; Institution; Lens Fiber; Molecular Chaperones; Research; Research Personnel; Resources; Source; Structure; United States National Institutes of Health; alpha-Crystallins; fiber cell; lens; monomer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. ?-crystallin, along the ?- and ?-crystallins, is one of the ubiquitous crystallins in vertebrate lenses. It is a major structural component of lens fiber cells and also has chaperone activity in these cells. In the lens, it is a hetero-oligomeric complex composed of two monomers ?A- and ?B-crystallin. We propose to use cry-EM to solve its structure.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 β-晶状体蛋白与α-和β-晶状体蛋白一样，是脊椎动物晶状体中普遍存在的晶状体蛋白之一。它是晶状体纤维细胞的主要结构成分，并且在这些细胞中也具有伴侣活性。在镜片中，它是由两个单体αA-和βB-晶状体蛋白组成的异源寡聚复合物。我们建议使用cry-EM来解析其结构。