Center for the Study of Inflammatory Bowel Disease

炎症性肠病研究中心

• 批准号: 8387708
• 负责人: Ramnik J Xavier
• 金额: $ 123.31万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8387708
• 关键词: Academic Medical Centers; Ally; Animal Model; Antigen-Presenting Cells; Architecture; Area; Award; Bacteria; Basic Science; Bioinformatics; Biological; Biological Process; Biology; Boston; Cell physiology; Cells; Chronic; Clinical; Clinical Research; Clinical Trials; Collaborations; Commit; Communities; Crohn' s disease; Development; Digestive System Disorders; Disease; Dissection; Drug Targeting; Educational workshop; Environmental Risk Factor; Epithelial; Epithelial Cells; Feasibility Studies; Fostering; Funding; Gene Chips; General Hospitals; Genetic; Genetic Research; Genomics; Goals; Grant; Hand; Healed; Human; Human Genetics; Immune response; Immunology; Inflammation; Inflammation Mediators; Inflammatory Bowel Diseases; Inflammatory disease of the intestine; Injury; Institutes; Institution; Intervention; Intestinal Mucosa; Israel; Knowledge; Leukocytes; Lymphocyte Activation; Lymphocyte antigen; Maps; Massachusetts; Medical center; Microbe; Molecular Biology; Morphology; Mucosal Immune Responses; Natural Immunity; Pathogenesis; Pathway interactions; Patients; Peptides; Population; Positioning Attribute; Predisposition; Process; Regulation; Research; Research Personnel; Research Support; Resources; Services; Site; Surface; Technology; Tissues; Training; Translational Research; Translations; Ulcerative Colitis; base; cohort; computerized tools; deep sequencing; genetic analysis; genetic variant; healing; immune function; improved; insight; member; microorganism interaction; mouse model; multidisciplinary; novel; novel strategies; programs; symposium; tool

The Center for the Study of Inflammatory Bowel Disease (CSIBD) is a multidisciplinary program to define fundamental mechanisms underlying Crohn's disease and Ulcerative colitis. This Center encompasses one hundred and one investigators at the Massachusetts General Hospital (MGH) and allied institutions pursuing research in a broad spectrum of basic science relevant to IBD. Since its formation nineteen years ago, the CSIBD has served as a vehicle to achieve advances in our understanding of these diseases through the study of relevant basic biological processes and the directed study of the diseases themselves. The research program of this Center is organized around the central hypothesis that IBD results from activation by luminal bacteria or their products of an upregulated chronic immune response due to genetically determined alterations of epithelial cell or immune function including a lack of appropriate down regulatory functions. Major advances made possible by the CSIBD in the years since its inception include the development and characterization of new genetic mouse models of IBD, delineation of mechanisms of lymphocyte activation and leukocyte recruitment to sites of inflammation, characterization of mechanisms of innate immune response, identification of key peptides involved in sustaining mucosal integrity, characterization of the mechanisms of mucosal healing following injury, improved understanding of the regulation of epithelial function, functional mapping of genetic variants in IBD, mucosal immune responses and delineation of the mechanisms of mucosal microbial interaction. Over the next five years, the CSIBD will promote further progress in the study of basic aspects of mucosal biology with translation to the study and treatment of IBD. A major focus of CSIBD research in the next five years will be the coordinated multi-disciplinary study of mechanisms leading to chronic intestinal inflammation and delineation of interactions between environmental factors and different genetic loci. The Center will also actively promote clinical and translational research efforts to apply insights gained in studying various disease mechanisms. The overall goal of advancing our knowledge of IBD will continue to be carried out through five Biomedical Cores. These include Genetic analysis, Genomics and Molecular Biology (GGMB), Morphology and Immunology Cores to provide access to advanced technologies. The Genetic Animal Models and Human Cell/Tissue Cores provide access to relevant animal models and patients for study. In the coming period facilitated access for CSIBD investigators to several platforms of the Broad institute has been arranged. CSIBD cores are heavily oriented towards hands on training. In addition to advancing the understanding of IBD per se, the goals of this Center will continue to include the recruitment of investigators committed to pursuing IBD research. These goals are fostered by Pilot/Feasibility Study awards which support new research initiatives as well as an enrichment program of seminars, workshops and symposia.

炎症性肠病研究中心 (CSIBD) 是一个多学科项目，旨在定义克罗恩病和溃疡性结肠炎的基本机制。该中心由马萨诸塞州总医院 (MGH) 和联合机构的 101 名研究人员组成，致力于与 IBD 相关的广泛基础科学研究。自 19 年前成立以来，CSIBD 一直是通过研究相关基本生物过程和对疾病本身进行定向研究来促进我们对这些疾病的理解的工具。该中心的研究项目围绕这样一个中心假设进行组织：炎症性肠病是由于上调的慢性免疫反应的腔内细菌或其产物的激活所致，这是由于基因决定的上皮细胞或免疫功能的改变（包括缺乏适当的下调功能）造成的。 CSIBD 自成立以来取得的主要进展包括新的 IBD 基因小鼠模型的开发和表征、淋巴细胞活化和白细胞募集到炎症部位的机制的描述、先天免疫反应机制的表征、参与维持粘膜完整性的关键肽、损伤后粘膜愈合机制的表征、提高对上皮功能调节的理解、IBD 遗传变异的功能图谱、粘膜免疫反应以及描述 IBD 的机制粘膜微生物相互作用。未来五年，CSIBD将推动粘膜生物学基础研究的进一步进展，并将其转化为IBD的研究和治疗。 CSIBD 未来五年研究的一个主要重点将是对导致慢性肠道炎症的机制进行协调的多学科研究，并描述环境因素与不同遗传位点之间的相互作用。该中心还将积极促进临床和转化研究工作，以应用在研究各种疾病机制中获得的见解。推进我们对 IBD 知识的总体目标将继续通过五个生物医学核心来实现。其中包括遗传分析、基因组学和分子生物学 (GGMB)、形态学和免疫学核心，以提供先进技术。遗传动物模型和人类细胞/组织核心提供了相关动物模型和患者的研究机会。在接下来的一段时间内，已经安排了 CSIBD 调查人员访问 Broad 研究所的多个平台的便利。 CSIBD 核心非常注重实践培训。除了增进对 IBD 本身的了解外，该中心的目标将继续包括招募致力于 IBD 研究的研究人员。这些目标是通过试点/可行性研究奖项来促进的，该奖项支持新的研究计划以及研讨会、讲习班和座谈会的丰富计划。