Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital

马萨诸塞州总医院炎症性肠病研究中心

• 批准号: 9262326
• 负责人: Ramnik J Xavier
• 金额: $ 6.21万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9262326
• 关键词: Advanced Development; Affect; Animal Model; Applied Research; Area; Back; Bacteria; Basic Science; Biology; Cell physiology; Cells; Cellular biology; Clinical; Collaborations; Communication; Communities; Complex; Crohn' s disease; Development; Diagnosis; Digestive System Disorders; Disease; Educational workshop; Engineering; Environment; Environmental Risk Factor; Epidemiologist; Epithelial; Epithelial Cells; Event; Fostering; Functional disorder; Funding; Gap Junctions; General Hospitals; Genetic; Genomics; Goals; Growth; Health; Human; Human Genetics; Human Microbiome; Immune; Immunologist; Immunology; Individual; Inflammatory; Inflammatory Bowel Diseases; Inflammatory disease of the intestine; Institutes; Institution; Lead; Massachusetts; Molecular; Morphology; Natural Immunity; Pathogenesis; Pathway interactions; Patients; Physiology; Productivity; Research; Research Personnel; Research Support; Resources; Route; Sampling; Scientist; Signal Transduction; System; Systems Biology; Technology; Therapeutic; Ulcerative Colitis; United States; adaptive immunity; base; disorder prevention; feeding; immune function; improved; insight; interest; intestinal homeostasis; member; microorganism interaction; programs; public health relevance; success; symposium; targeted treatment; technology development; Advanced Development; Affect; Animal Model; Applied Research; Area; Back; Bacteria; Basic Science; Biology; Cell physiology; Cells; Cellular biology; Clinical; Collaborations; Communication; Communities; Complex; Crohn' s disease; Development; Diagnosis; Digestive System Disorders; Disease; Educational workshop; Engineering; Environment; Environmental Risk Factor; Epidemiologist; Epithelial; Epithelial Cells; Event; Fostering; Functional disorder; Funding; Gap Junctions; General Hospitals; Genetic; Genomics; Goals; Growth; Health; Human; Human Genetics; Human Microbiome; Immune; Immunologist; Immunology; Individual; Inflammatory; Inflammatory Bowel Diseases; Inflammatory disease of the intestine; Institutes; Institution; Lead; Massachusetts; Molecular; Morphology; Natural Immunity; Pathogenesis; Pathway interactions; Patients; Physiology; Productivity; Research; Research Personnel; Research Support; Resources; Route; Sampling; Scientist; Signal Transduction; System; Systems Biology; Technology; Therapeutic; Ulcerative Colitis; United States; adaptive immunity; base; disorder prevention; feeding; immune function; improved; insight; interest; intestinal homeostasis; member; microorganism interaction; programs; public health relevance; success; symposium; targeted treatment; technology development

 DESCRIPTION, OVERALL (provided by applicant): The overall goal of the Center for the Study of Inflammatory Bowel Disease (CSIBD) is to promote and facilitate research that will yield insight into the causes and pathogenesis of IBD and lead to improved therapeutic approaches. This overarching objective remains unchanged since the inception of the CSIBD in 1991 and has guided the Center through substantial growth and expansion. The research base is made up of 111 scientists with $48.7 million in digestive disease-related research support. Organizing these investigators by areas of focus, we divide the CSIBD into six central themes. Our goal of understanding human IBD is accomplished using six entry points: (1) genetics, (2) microbial interactions, (3) barrier function and epithelial cell biology, (4) innate and adaptive immunity, (5) therapeutics, and (6) systems biology and signal transduction. Clinicians, scientists, and engineers are embedded in each theme. A central priority of the CSIBD is to bring together researchers from these various approaches and to provide an intellectual nexus for these individuals to find common interests in understanding and treating IBD. This is accomplished through several routes. First, the five biomedical cores offer state-of-the-art resources and expertise from leaders in (1) Human Genetics and Microbiome, (2) Immunology, (3) Morphology, and (4) Genetic Animal Models. In addition to offering guidance and access to technologies, core directors serve as connection points between investigators, facilitating collaborations. Similarly, the (5) Clinical Core aids the community through access to thousands of patient samples while serving as a hub for interactions between clinicians and basic researchers. Operating independently of these cores, the close relationship between the CSIBD and the Broad Institute allows further access to cutting-edge technologies. The overall specific aims of the CSIBD are to (1) promote research in basic science areas relevant to better understanding of mucosal immune function and epithelial biology in IBD; (2) advance our understanding of gut pathophysiology by examining the gut as a "circuit": studying the core components of gut intra- and inter-cellular interactions that determine health and disease; (3) promote the study of the pathogenesis of IBD; (4) promote interactions among scientists exploring diverse fields that share relevance to IBD; (5) promote translational IBD research; (6) attract basic investigators to the study of IBD and mucosal immunology; and (7) provide an environment and mechanism to foster development of young investigators focused on IBD. A comprehensive Enrichment Program introduces new members to the IBD community and encourages face-to-face interactions between investigators from a range of fields. Attracting new members to the CSIBD and IBD research is also greatly facilitated through Pilot and Feasibility Program support, the success of which is reflected by 79% of recipients achieving external funding.

 描述，总体上（由适用提供）：炎症性肠病研究中心（CSIBD）的总体目标是促进和促进研究，从而深入了解IBD的原因和发病机理并导致改善治疗方法。自1991年CSIBD成立以来，这个总体目标一直保持不变，并通过实质性的增长和扩张来指导中心。该研究基础由111位科学家组成，具有4,870万美元的消化性疾病有关的研究支持。我们按重点领域组织这些研究人员，将CSIBD分为六个中心主题。我们了解人IBD的目标是使用六个入口点来实现的：（1）遗传学，（2）微生物相互作用，（3）屏障功能和上皮细胞生物学，（4）先天和适应性免疫学，（5）治疗，以及（6）系统生物学和信号转移。临床医生，科学家和工程师都嵌入了每个主题中。 CSIBD的一个核心优先事项是将研究人员从各种方法中汇集在一起​​，并为这些人提供理解和治疗IBD方面的共同利益。这是通过多个路线完成的。首先，这五个生物医学核心提供了（1）人类遗传学和微生物组领导者的最先进资源和专业知识，（2）免疫学，（3）形态学和（4）遗传动物模型。除了提供指导和获取技术的访问外，核心主管还作为调查人员之间的联系点，支持合作。同样，（5）临床核心通过获得数千名患者样本的访问，同时充当临床医生与基础研究人员之间的相互作用的枢纽，从而有助于社区。 CSIBD与广泛研究所之间的密切关系独立于这些核心，可以进一步访问最先进的技术。 CSIBD的总体具体目的是（1）促进与更好地理解IBD粘膜免疫功能和上皮生物学有关的基础科学领域的研究； （2）通过检查肠道作为“电路”：研究肠道内和细胞间相互作用的核心成分，以提高我们对肠道病理生理的理解； （3）促进IBD发病机理的研究； （4）促进探索与IBD相关的潜水领域的科学家之间的互动； （5）促进翻译IBD研究； （6）吸引基本研究人员对IBD和粘膜免疫学研究； （7）提供了一种环境和机制，以促进专注于IBD的年轻研究人员的发展。一项全面的丰富计划向新成员介绍了IBD社区，并鼓励来自各个领域的调查人员之间的面对面互动。通过试点和可行性计划的支持，吸引新成员进入CSIBD和IBD研究也得到了很好的支持，其成功反映了79％的接收者获得外部资金。