FLYBASE: A DROSOPHILA GENOMIC AND GENETIC DATABASE

Flybase：果蝇基因组和遗传数据库

• 批准号: 8665574
• 负责人: WILLIAM MARTIN GELBART
• 金额: $ 327.99万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-08-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8665574
• 关键词: Ally; Animal Experimentation; Biological; Biological Models; Biology; Biomedical Research; Caring; Communicable Diseases; Communities; Culicidae; Data; Data Set; Databases; Development; Drosophila genome; Drosophila genus; Drosophila melanogaster; Drosophilidae; Educational workshop; Etiology; Evolution; Experimental Models; Freezing; Genbank; Gene Family; Genes; Genetic; Genetic Databases; Genetic Models; Genome; Genomics; Goals; Grant; Hereditary Disease; Human Genetics; Individual; Informatics; Insect Vectors; Journals; Link; Literature; Macromolecular Complexes; Malaria; Manuals; Maps; Metadata; Modeling; Molecular Genetics; Ontology; Output; Paper; Pathway interactions; Phenotype; Procedures; Production; Proteins; Reagent; Reporting; Research; Research Infrastructure; Resource Informatics; Resources; Role; Running; Science; Series; Site; Structure; Study models; Suggestion; System; Time; Training; Triage; Update; West Nile virus; Work; cost; data integration; data integrity; data mining; data sharing; fly; functional genomics; genome analysis; human disease; insight; interoperability; model organisms databases; outreach; symposium; systems research; text searching; tool; web interface; web site

DESCRIPTION (provided by applicant): FlyBase is the core genomic / genetic Model Organism Database (MOD) for the important biomedical model, Drosophila melanogaster and related species of flies. Drosophila is one of the premiere animal research systems and can be used very cost-effectively to help understand the etiology of human genetic diseases and is the closest experimental model that care provide insights into the biology of insect vectors of human disease (such as mosquitos that carry major infectious diseases such as malaria. West Nile Virus. The goals are twofold: (1) to provide a centralized resource for Drosophila genetic/genomic data and experimental reagents in order to enable Drosophila research to advance as rapidly as possible and (2) to provide these results to the broader biomedical research community to further their own research. FlyBase captures data from the primary scientific literature and from large-scale genome analysis and functional genomics community resource projects through annotation by FlyBase curators, direct user submissions and automated text-mining. FlyBase and collaborating informatics resources extensively share data thereby leveraging the output of each group. These heterogeneous data are organized into coherent datasets and integrated in a central database according to a series of ontology organizing systems. On a bi-monthly basis, these data are extracted from the central FlyBase database and served to the entire scientific community through a freely accessible FlyBase website, which is accessed millions of times each month. In addition to providing the research community to ttie corpus of FlyBase-captured data in ways that can be readily interrogated and browsed, FlyBase also maintains millions of links to other biomedical websites providing other relevant information. Over the proposed 5-year grant period, FlyBase expects to contribute to the enhancement of MOD interoperability and to work with a broad range of informatics resources and journal publishers to provide as rich a set of data and data-mining tools as possible to the biomedical research community. RELEVANCE: FlyBase provides crucial data and informatic infrastructure to accelerate the pace of Drosophila research and for the broader biomedical sciences community to leverage these discoveries to further their own research. Drosophila is now a well-accepted experimental model for human disease research and is the closest genetic / genomic experimental model system for research on the insect vectors that carry human diseases.

描述（由申请人提供）：Flybase是重要的生物医学模型，果蝇Melanogaster和相关蝇物种的核心基因组 /遗传模型生物数据库（MOD）。果蝇是首屈一指的动物研究系统之一，可以非常成本地使用以帮助了解人类遗传疾病的病因学，并且是最接近的实验模型，它是对人类疾病的昆虫媒介生物学提供见解的最接近的实验模型（例如，蚊子（例如携带了诸如疟疾的主要感染疾病），例如疟疾。遗传/基因组数据和实验试剂使果蝇的研究能够尽可能快地进步，并且（2）向更广泛的生物医学研究界提供这些结果，以进一步捕获其自身的研究数据信息学资源广泛共享数据，从而利用每个组的输出。这些异质数据被组织到相干数据集中，并根据一系列本体论组织系统集成到中央数据库中。每两个月，这些数据是从中央Flybase数据库中提取的，并通过可自由访问的Flybase网站向整个科学界提供了服务，该网站每月可访问数百万次。除了将研究社区提供以容易受到询问和浏览的方式提供Flybase捕获数据的语料库外，Flybase还保持了数百万个与其他相关信息的其他生物医学网站的链接。在拟议的5年赠款期内，Flybase希望为增强MOD互操作性的增强做出贡献，并与广泛的信息学资源和期刊出版商合作，以尽可能丰富的数据和数据挖掘工具为生物医学研究社区提供。 相关性：FlyBase提供了关键的数据和信息基础设施，以加快果蝇研究的速度以及更广泛的生物医学科学社区，以利用这些发现来进一步进行自己的研究。果蝇现在是人类疾病研究的一个良好接受的实验模型，是对携带人类疾病的昆虫媒介进行研究的最接近的遗传 /基因组实验模型。