FLYBASE: A DROSOPHILA GENOMIC AND GENETIC DATABASE

Flybase：果蝇基因组和遗传数据库

• 批准号: 7942698
• 负责人: WILLIAM MARTIN GELBART
• 金额: $ 41.72万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7942698
• 关键词: Behavioral; Biological; Biological Process; Biology; Cell Line; Communities; Complex; Computer software; Data; Data Collection; Data Set; Data Sources; Databases; Developmental Cell Biology; Disease; Distant; Drosophila genome; Drosophila genus; Drosophila melanogaster; Ecology; Electronic Mail; Engineering; Evolution; Explosion; Feedback; Frequencies; Funding; Funding Agency; Genes; Genetic; Genetic Databases; Genetic Models; Genome; Genomics; Grant; Health; Human; Human Biology; Immune Sera; Insect Vectors; Insecta; Institutes; International; Investigation; Literature; Manuals; Minority; Mission; Modeling; Molecular; Mutation; National Human Genome Research Institute; Neurobiology; New Mexico; Pathway interactions; Play; Population; Population Biology; Production; Reagent; Recording of previous events; Research; Research Infrastructure; Research Personnel; Resource Informatics; Role; Site; Software Tools; Structure; Surveys; System; United States National Institutes of Health; Universities; Update; Variant; Work; base; comparative; fly; functional genomics; gene function; genome sequencing; genome-wide; innovation; insight; meetings; model organisms databases; open source; research study; tool; trait; web site

DESCRIPTION (provided by applicant): FlyBase is a long-term informatics resource that provides the scientific community with core genetic and genomic information on the major biomedical genetic model, Drosophila melanogaster, and other flies of the genus Drosophila. With the continuing explosion of information in major genome-wide datasets as well as the scientific literature, the role of a model organism database in capturing, organizing and distilling the key information is essential to researchers using Drosophila as their experimental system, to groups using the results of Drosophila research to inform their studies on other systems (including researchers focusing on humans), and to computational biologists who require such comprehensive, well structured data sources. FlyBase will continue to curate the scientific literature, annotate the D. melanogaster genome through expert manual curation, annotate the other Drosophila species by a combination of automatic and selective manual approaches, and capture large-scale functional genomics datasets. These diverse sets of data will be integrated within the FlyBase database and presented to the public through regular monthly updates to the FlyBase website (http://flybase.org). FlyBase thus serves as one of the public portals to data produced by a variety of sequencing and functional genomics projects supported by NHGRI and the other institutes of NIH, as well as by other U.S. and international funding agencies, and to the research literature that is produced in part by taking advantage of these major datasets. Joining the three currently participating FlyBase sites for this renewal is a group at the University of New Mexico which will play a central role in the FlyBase Minority Action Plan. RELEVANCE: Research on Drosophila melanogaster continues to be at the forefront of studies of biological pathways and networks in the context of cell and developmental biology, neurobiology and behavioral biology. It has also been one of the most significant systems for studying variation, complex traits, population biology, ecology and evolution. The insights from Drosophila research are of direct importance to human health research, both because of the tremendous similarities between the Drosophila and human gene sets and biological processes, allowing Drosophila research to inform studies of human biology and disease, but also because Drosophila melanogaster is the closest model for research on insect vectors of disease.

描述（由申请人提供）：Flybase是一种长期信息学资源，可为科学界提供有关主要生物医学遗传模型，果蝇Melanogaster和果蝇属的其他苍蝇的核心遗传和基因组信息。随着主要全基因组数据集中信息的持续爆炸以及科学文献，模型有机体数据库在捕获，组织和提炼关键信息中的作用对于使用果蝇作为其实验系统的研究人员是必不可少的，使用果蝇的结果将果蝇研究的结果与其他研究人员进行了研究（包括研究人员的研究），并将其用于研究人员，并将其用于研究人员，并将其用于研究人员，并将其构成研究，以构成幽默的研究。 Flybase将继续策划科学文献，通过专家手动策展注释D. Melanogaster基因组，通过自动和选择性手动方法的结合来注释其他果蝇物种，并捕获大规模的功能基因组数据组数据集。这些不同的数据集将集​​成在Flybase数据库中，并通过定期每月更新到Flybase网站（http://flybase.org）向公众呈现。因此，Flybase是由NHGRI和NIH其他机构以及其他美国和国际资助机构支持的各种测序和功能基因组项目生产的数据的公共门户之一，以及部分通过利用这些主要数据集的优势而生产的研究文献。新墨西哥大学将加入目前参与的三个飞行基地网站以进行此续签，这将在Flybase少数民族行动计划中发挥核心作用。相关性：在细胞和发育生物学，神经生物学和行为生物学的背景下，对果蝇的研究继续处于生物途径和网络研究的最前沿。它也是研究变异，复杂性状，种群生物学，生态学和进化的最重要系统之一。果蝇研究的见解对人类健康研究至关重要，这既是果蝇和人类基因组之间的巨大相似之处和生物学过程，从而使果蝇研究可以为人类生物学和疾病的研究提供依据，但由于果蝇黑素果师是疾病昆虫毒性的最接近的研究模型。