University of North Carolina Womens Interagency HIV Study UNC WIHS

北卡罗来纳大学妇女机构间艾滋病毒研究 UNC WIHS

基本信息

批准号：
8604138
负责人：
ADAORA A ADIMORA
金额：
$ 184.45万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-01-10 至 2017-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8604138
关键词：
Acquired Immunodeficiency Syndrome Address Affect Age Aging Atlases Biostatistical Methods Blood Cancerous Caring Cervical dysplasia Clinic Cohort Studies Collaborations Communicable Diseases Complement Comprehensive Cancer Center Data Disease Enrollment Epidemic Epidemiologic Methods Epidemiology Female Genital system Genome Geographic Locations HIV HIV Infections HIV Seropositivity Health Health Insurance Health Services Accessibility Health Services Research Healthcare Heart High Risk Woman Human Genome Human Papillomavirus Immune Immunologic Surveillance Income Individual Inequality Infection Inflammation Insurance Coverage Interdisciplinary Study Intervention Investigation Lead Lesion Life Malignant Neoplasms Malignant neoplasm of cervix uteri Menopause Methods Microbial Genetics Molecular Biology Neighborhoods North Carolina Outcome Pathogenesis Pathway interactions Physiological Plasma Policies Population Postmenopause Poverty Premenopause Prevention Recruitment Activity Research Research Personnel Risk Role Rural Sampling Science Screening for cancer Serum Site Statistical Methods Statutes and Laws Target Populations Time Tissues To specify United States National Institutes of Health Universities Vagina Viral Woman base blood pressure regulation cancer genome cancer therapy cohort contextual factors cytokine experience follow-up genome wide association study high risk improved innovation malignant breast neoplasm men microbiome multidisciplinary multilevel analysis novel programs public health relevance social socioeconomics trafficking tumor progression tumorigenesis virus genetics virus host interaction

项目摘要

DESCRIPTION (provided by applicant): This application proposes to establish The University of North Carolina at Chapel Hill as a new site for the Women's Interagency HIV Study (WIHS). The proposal represents a collaborative effort between investigators from The UNC Center for Infectious Diseases, Center for AIDS Research, Lineberger Comprehensive Cancer Center, and Cecil G. Sheps Center for Health Services Research. We propose to rapidly establish the UNC-WIHS cohort, contribute meaningfully to the national WIHS scientific program, and undertake an ambitious HIV research agenda that encompasses social epidemiology and health outcomes, advanced epidemiologic and biostatistical methods, pathogenesis, and molecular biology of cancer. We aim to: 1) Recruit and retain in follow-up a cohort of 200 HIV+ and 100 HIV- women who are at high risk for HIV infection and represent NC's HIV epidemic, thus expanding the WIHS Cohort to women who live in a region at the forefront of the US epidemic; 2) Characterize the relationship between socioeconomic context, changes in access to health insurance, and health outcomes among HIV+ and HIV- women; 3) Develop and apply novel epidemiologic and statistical methods using data from the UNC-WIHS and the entire WIHS cohort; 4) Characterize HIV persistence in the blood and genital tract among pre- and post-menopausal women; and 5) Investigate the pathobiology of breast and cervical cancers to identify immunological, microbial and genetic factors that affect cancer progression and treatment in HIV positive women. By contributing a diverse and complementary population of women, innovative science, and a strong, multidisciplinary cadre of investigators, UNC will enhance the efforts of the WIHS, expand the range of questions that can be addressed and, in collaboration with the entire group, improve the health of HIV+ women and women at high risk for HIV infection.

描述（由申请人提供）：本申请建议在教堂山建立北卡罗来纳大学，作为妇女跨性别艾滋病毒艾滋病毒研究（WIHS）的新地点。该提案代表了UNC传染病中心，艾滋病研究中心，Lineberger综合癌症中心和Cecil G. Sheps Health Services Research中心的研究人员之间的合作努力。我们建议迅速建立UNC-WIHS队列，为国家WIHS科学计划做出有意义的贡献，并进行雄心勃勃的HIV研究议程，其中包括社会流行病学和健康成果，高级流行病学和生物统计学方法，病原体和癌症的分子生物学。我们的目标是：1）招募并保留了200 HIV+和100名HIV妇女的招募和艾滋病毒感染风险高的妇女，并代表了NC的HIV流行，从而将WIHS队列扩大到生活在美国最前沿的地区的妇女； 2）表征社会经济环境，获得健康保险的变化以及艾滋病毒+和艾滋病毒妇女之间的健康成果之间的关系； 3）使用来自UNC-WIHS和整个WIHS队列的数据开发和应用新的流行病学和统计方法； 4）表征了绝经前和绝经后妇女血液和生殖道的艾滋病毒持续性； 5）研究乳腺癌和宫颈癌的病理学，以鉴定影响HIV阳性女性癌症进展和治疗的免疫，微生物和遗传因素。通过贡献多样化和互补的妇女人群，创新的科学以及强大的多学科研究人员，UNC将加强WIHS的努力，扩大可以解决的问题的范围，并与整个小组合作，改善HIV+妇女的健康和妇女的健康和妇女的健康，感染HIV高风险。