UNC MACS/WIHS Combined Cohort Study Clinical Research Site

北卡罗来纳大学 MACS/WIHS 联合队列研究临床研究网站

基本信息

批准号：
10370391
负责人：
ADAORA A ADIMORA
金额：
$ 279.62万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-01 至 2026-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10370391
关键词：
AIDS clinical trial group Acquired Immunodeficiency Syndrome Address Affect Aging American Area Behavioral Research Biological Markers Blood Cardiovascular Diseases Cardiovascular system Characteristics Chronic Chronic Obstructive Pulmonary Disease Chronic lung disease Clinical Cohort Studies Collaborations Communicable Diseases Complement Comprehensive Cancer Center Consent Data Analyses Disease Disease remission Enrollment Epidemic Epidemiologic Methods Ethnic Origin Female Funding Geography Gills Grant Guidelines HIV HIV Infections HIV Seropositivity HIV prevention trials network Health Health Policy Health Services Research Incidence Individual Infection Infrastructure Institutes Insurance Coverage Interruption Intervention Lead Leadership Link Lung Malignant Neoplasms Malignant neoplasm of lung Methods Myocardial Infarction Nature Neighborhoods Neurocognitive North Carolina Outcome Participant Pathogenesis Persons Pharmacy Schools Plasma Population Prevention Public Health Publications Race Research Research Personnel Respiratory Signs and Symptoms Risk Risk Factors Schools Science Sex Differences Site Socioeconomic Status Stroke System The Multicenter AIDS Cohort Study Tissue Procurements Tissues Universities Viral Load result Viral reservoir Virus Latency Woman Women&apos s Interagency HIV Study antiretroviral therapy career clinical research site cohort collaboratory comorbidity design effective intervention gender difference global health health disparity high risk high risk population improved innovation interest male male health men mortality multidisciplinary novel participant enrollment programs pulmonary function pulmonary function decline research study sex social epidemiology

项目摘要

PROJECT SUMMARY/ABSTRACT This application proposes to establish The University of North Carolina at Chapel Hill as a Clinical Research Site (CRS) for the Multicenter AIDS Cohort Study (MACS)/Women’s Interagency HIV Study (WIHS) Combined Cohort Study (MACS/WIHS-CCS). The proposal represents a collaborative effort between investigators from The UNC Institute for Global Health and Infectious Diseases, Center for AIDS Research, UNC Gillings School of Global Public Health, Lineberger Comprehensive Cancer Center, Eshelman School of Pharmacy, and Cecil G. Sheps Center for Health Services Research. We propose to rapidly establish the UNC MACS/WIHS-CCS CRS, contribute meaningfully to the MACS/WIHS- CCS (CCS) Unified Science Agenda, and undertake ambitious research that encompasses pulmonary, cardiovascular, neurocognitive, and other HIV-related comorbidities; HIV pathogenesis/cure; social epidemiology and health outcomes; behavioral research; and advanced epidemiologic methods. We aim to: (1) Enroll 310 male and female participants who reflect the HIV epidemic in the southeastern US, and re-consent current WIHS enrollees for participation in the CCS; (2) Lead critical components of the CCS Unified Science Agenda; (3) Support all aspects of the CCS Science Agenda at the UNC CRS. By contributing a representative population of men and women, innovative science, and a strong, multidisciplinary cadre of investigators, UNC will enhance the efforts of the CCS, expand the range of questions that can be addressed and, in collaboration with the entire group, improve the health of men and women with or at high risk for HIV infection.

项目摘要/摘要该申请提案旨在建立北卡罗来纳大学教堂山分校作为临床研究多中心艾滋病队列研究（MAC）/妇女妇女间艾滋病毒研究（WIHS）的地点（CRS）合并队列研究（MAC/WIHS-CCS）。该提案代表了调查人员之间的合作努力 UNC全球健康与传染病研究所，艾滋病研究中心，UNC Gillings学校 Lineberger综合癌症中心，Eshelman药学院和Cecil的全球公共卫生中心 G. SHEPS卫生服务研究中心。我们建议快速建立UNC Mac/WIHS-CCS CR，对Mac/Wihs-有意义地贡献 CCS（CCS）统一科学议程，并进行雄心勃勃的研究，包括肺部，心血管，神经认知和其他与HIV相关的合并症； HIV发病机理/治疗；社会的流行病学和健康成果；行为研究；和高级流行病学方法。我们的目标是：（1）注册310名反映美国东南部艾滋病毒流行病的男性和女性参与者，并重新融合当前的WIHS参加CCS；（2）CCS的主要关键组件统一科学议程；（3）支持UNC CRS的CCS科学议程的各个方面。通过贡献代表性的男人和女性，创新的科学以及强大的， UNC的多学科研究人员将加强CCS的努力，扩大可以解决的问题，并与整个小组合作，改善男性的健康和艾滋病毒感染风险或高风险的妇女。