MWCCS Administrative Supplement: Association of Oral Microbiome, HIV, and Pulmonary Function

MWCCS 行政补充：口腔微生物组、HIV 和肺功能的关联

• 批准号: 10657042
• 负责人: ADAORA A ADIMORA
• 金额: $ 16.44万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10657042
• 关键词: Acquired Immunodeficiency Syndrome; Address; Administrative Supplement; Alcohol consumption; Bacteria; Biological Assay; Blood specimen; Cell Separation; Chronic Obstructive Pulmonary Disease; Data; Dental; Dental Care; Dental caries; Diet; Disease; Environment; Evaluation; Funding; Gingivitis; HIV; HIV Seronegativity; Health; Host Defense; Immune response; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Immunoglobulins; Immunologic Markers; Individual; Inflammation; Inflammatory Response Pathway; Influentials; Intervention; Investigation; Lesion; Link; Lung diseases; Magnetism; Measurement; Measures; Medicine; Microbe; Oral; Oral Administration; Oral cavity; Oral health; Oral mucous membrane structure; Participant; Periodontitis; Peripheral; Persons; Pulmonary Emphysema; Pulmonary function tests; Quality of life; Research; Research Personnel; Role; Saliva; Sampling; Science; Smoking; Techniques; Testing; Toothbrushing; Training; United States National Institutes of Health; Visit; airway obstruction; antiretroviral therapy; comorbidity; cytokine; dysbiosis; fungus; improved; insight; interdisciplinary collaboration; lung health; microbial; microbial community; microbiome; microbiome analysis; next generation; novel; novel strategies; oral lesion; oral microbiome; pulmonary function; saliva sample; social health determinants; sociodemographic factors; soft tissue; therapy development; vaping

PROJECT ABSTRACT FY 2022 OAR Strategic Funds are requested to perform a detailed investigation of the relationship of the oral microbiome, immune response, and HIV to chronic obstructive pulmonary disease (COPD). COPD, including airway obstruction and emphysema, is an increasing health problem in people with HIV (PWH) even in the current era of antiretroviral therapy (ART). Our preliminary data suggest that the oral microbiome is associated with lung function, but we lack a detailed understanding of the role of particular microbial communities and the potential mechanisms underpinning the association, which currently impedes development of intervention strategies. We will utilize oral data, microbiome analyses, blood specimens, and pulmonary function measures already being collected throughout MWCCS in visits 102 and 103 in order to analyze the relationship of oral health and the oral microbiome to lung function. We will also perform measurements of peripheral cytokines, inflammatory responses, and the oral cavity environment to assess potential mechanisms linking the microbiome to lung health. These investigations will be performed in all individuals who have completed pulmonary function testing across MWCCS. We will then perform detailed oral evaluations and collect microbial samples from multiple oral niches in a subset of participants to better delineate relationships of specific oral health components and lung function at Pitt and UNC. Using a novel technique to identify immunoglobulin-bound bacteria and fungi, we will identify key microbes that drive host response and are related to COPD. These investigations will identify potentially modifiable targets contributing to COPD in PWH. We will address NIH high priority AIDS-designated topics of: 1) a common and high-burden HIV- associated comorbidity; 2) interdisciplinary collaborations among experts in pulmonary disease, microbiome, dental medicine, and analytics; 3) disparities in HIV given impact of social determinants of health on both lung function and oral health; 4) fundamental discovery in cross-cutting science; and 5) training the next generation of HIV investigators. These investigations will build on the previous research conducted by the MWCCS and provide insight into a novel mechanism of HIV-associated lung disease with potential to develop new interventions to modulate the oral microbiome to improve pulmonary function.

项目摘要 2022财年，要求桨战略基金对 口服微生物组，免疫反应和HIV对慢性阻塞性肺疾病（COPD）。 COPD，包括气道阻塞和肺气肿，是患有患者的健康问题 即使在当前的抗逆转录病毒疗法（ART）时代，艾滋病毒（PWH）也是如此。我们的初步数据表明 口服微生物组与肺功能有关，但我们对 特定的微生物群落和协会支撑的潜在机制， 目前阻碍了干预策略的发展。我们将利用口头数据，微生物组 分析，血液标本和肺功能度量已经在整个过程中收集 访问102和103的MWCC，以分析口腔健康和口腔的关系 微生物组至肺功能。我们还将对周围细胞因子，炎症进行测量 响应以及评估将微生物组联系起来的潜在机制的口腔环境 肺部健康。这些调查将在所有完成肺部的人中进行 跨MWCC的功能测试。然后，我们将进行详细的口服评估并收集微生物 一部分参与者的多个口腔壁ches的样本，以更好地描述特定的关系 皮特和UNC的口腔健康成分和肺功能。使用一种新技术来识别 免疫球蛋白结合细菌和真菌，我们将确定驱动宿主反应和的关键微生物 与COPD有关。这些调查将确定潜在的可修改目标 PWH中的COPD。 我们将解决NIH高优先级艾滋病指定的主题：1）常见且高负责的HIV- 相关的合并症； 2）肺部疾病专家之间的跨学科合作， 微生物组，牙科医学和分析； 3）艾滋病毒的差异给定社会决定因素的影响 肺功能和口腔健康的健康； 4）跨裁判科学中的基本发现； 5） 培训下一代艾滋病毒调查人员。 这些调查将基于MWCC的先前研究并提供洞察力 成为一种新型的与HIV相关的肺疾病的机制，有可能开发出新的干预措施 调节口服微生物组以改善肺功能。

项目成果

Corrigendum to: Clinical Effectiveness of Integrase Strand Transfer Inhibitor-Based Antiretroviral Regimens Among Adults With Human Immunodeficiency Virus: A Collaboration of Cohort Studies in the United States and Canada.

勘误表：基于整合酶链转移抑制剂的抗逆转录病毒治疗方案在成人人类免疫缺陷病毒患者中的临床有效性：美国和加拿大队列研究的合作。

• DOI: 10.1093/cid/ciab799
• 发表时间: 2022
• 期刊: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
• 作者: Lu,Haidong;Cole,StephenR;Westreich,Daniel;Hudgens,MichaelG;Adimora,AdaoraA;Althoff,KeriN;Silverberg,MichaelJ;Buchacz,Kate;Li,Jun;Edwards,JessieK;Rebeiro,PeterF;Lima,VivianeD;Marconi,VincentC;Sterling,TimothyR;Horberg,
• 通讯作者: Horberg,