An Ultra High Resolution SPECT System Integrated with a High-Field MRI Scanner

与高场 MRI 扫描仪集成的超高分辨率 SPECT 系统

基本信息

批准号：
8689823
负责人：
Chin-Tu Chen
金额：
$ 34.24万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-01 至 2017-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8689823
关键词：
Accounting Address Affect Algorithms Animals Anodes Area Arts Autoimmune Process Bioluminescence Caliber Cathodes CdZnTe Cell Count Cells Chicago Collimator Contrast Media Coupled Custom Detection Development Diabetes Mellitus Dimensions Electronics Event Fluorescence Generations Geometry Grant Hemorrhage Image Imaging Techniques Immunologic Monitoring Incidence Insulin-Dependent Diabetes Mellitus Laboratories Laboratory Research Location Magnetic Resonance Imaging Magnetism Medical Metabolic Methods Mission Modeling Monitor Mus Non-Insulin-Dependent Diabetes Mellitus Nuclear Optics Performance Persons Photons Positioning Attribute Positron-Emission Tomography Quantitative Evaluations Radioactivity Radiolabeled Research Resolution Signal Transduction Stem cells Structure of beta Cell of islet System T-Lymphocyte Techniques Thick Time Tissues Transplantation United States Wages Work absorption base cell motility cellular imaging cost design detector image reconstruction imaging modality in vivo in vivo imaging instrument iron oxide islet light scattering magnetic field migration novel prototype radiotracer research study response single photon emission computed tomography soft tissue stem tumor ultra high resolution

项目摘要

DESCRIPTION (provided by applicant): In this project, we will develop a novel imaging system that combines a high-field MRI scanner and an ultrahigh resolution SPECT system for imaging metabolic and signaling targets in the pancreatic beta cell. This combined system comprises a 9.4 T 30 cm horizontal bore magnet (Oxford Instrument, Oxford, UK) with Bruker Avance Biospec (Bruker-Biospin, Billerica, MA) console equipped with 12 cm shielded gradient with maximum strength of 400mT/m, and a compact and ultrahigh resolution SPECT system that will be fitted inside the 12 cm diameter bore to allow simultaneous MR and SPECT imaging of mouse. The proposed SPECT system is based on an energy-resolved photon counting detector. It consists of pixelated CdZnTe (CZT) crystals (with 350 5m W 350 5m pitch), coupled to a custom- designed readout circuitry that utilizes an energy-resolved photon-counting (ERPC) ASIC (developed by Dr. Meng's group at UI) to readout anode pixels and the NCI-ASIC (developed by Brookhaven National Laboratory and Naval Research Laboratory) to readout the cathode signals. The ERPC detector offers (a) an ultrahigh intrinsic spatial resolution (<400 5m in all three dimensions) for 140keV 3-rays, (b) a wide dynamic range to cover 12-200keV, (c) a proven MRI- compatibility with minimized magnetic components, (d) the ability to extract signals simultaneously induced on adjacent anode pixels and the cathode, which provides critical information for correcting the event positioning error induced by the strong magnetic field, and (e) a compact form factor for packing multiple detectors into the MRI bore. The proposed imaging system combines a high-field (9.4 T) MRI scanner with an ultrahigh SPECT system. It allows an excellent co-registration of the features resolved in both MR and SPECT images. The proposed system will be applied for imaging metabolic and signaling targets in the pancreatic beta cell. The results of studies will enhance our understanding of the advantages and limitations of each imaging modality in specific models of 2cell loss and replication.

描述（由申请人提供）：在此项目中，我们将开发一个新型的成像系统，该系统结合了高场MRI扫描仪和一个超高分辨率SPECT系统，用于成像胰腺β单元中的代谢和信号靶标。 This combined system comprises a 9.4 T 30 cm horizontal bore magnet (Oxford Instrument, Oxford, UK) with Bruker Avance Biospec (Bruker-Biospin, Billerica, MA) console equipped with 12 cm shielded gradient with maximum strength of 400mT/m, and a compact and ultrahigh resolution SPECT system that will be fitted inside the 12 cm diameter bore to allow simultaneous MR and SPECT imaging of 老鼠。拟议的SPECT系统基于能量分辨的光子计数检测器。它由像素化的CDZNTE（CZT）晶体（350 5m W 350 5m螺距）组成，并与定制设计的读数电路相结合，该电路利用能量分辨的光子计数（ERPC）ASIC（ERPC）ASIC（由UI的Meng Group）开发，由UI博士开发，以读取Anci-aver and andode andode and anci-aver and anci-aver and anci-aven and anci-aven broshav and broshav and broshaven broshav and broshav and broshaven broshav and broshav and broshav and broshav and broshaven阴极信号。 The ERPC detector offers (a) an ultrahigh intrinsic spatial resolution (<400 5m in all three dimensions) for 140keV 3-rays, (b) a wide dynamic range to cover 12-200keV, (c) a proven MRI- compatibility with minimized magnetic components, (d) the ability to extract signals simultaneously induced on adjacent anode pixels and the cathode, which provides critical information for correcting the event由强磁场引起的定位误差，以及（e）将多个检测器堆积到MRI孔中的紧凑型构想。提出的成像系统将高场（9.4 T）MRI扫描仪与超高SPECT系统相结合。它允许对在MR和SPECT图像中分析的功能进行出色的共同注册。所提出的系统将用于胰腺β细胞中的成像代谢和信号传导靶标。研究结果将增强我们对2细胞丢失和复制模型中每种成像方式的优势和局限性的理解。