The 5th US-EU Conference on Endogenous DNA Damage

第五届美国-欧盟内源性 DNA 损伤会议

基本信息

批准号：
8785881
负责人：
Alan E Tomkinson
金额：
$ 2.9万
依托单位：
UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-07-15 至 2015-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8785881
关键词：
Abnormal DNA Repair Address Affect Aging Alkylating Agents Area Basic Science Cell physiology Cities Collaborations DNA DNA Damage DNA Modification Process DNA Repair Pathway DNA lesion Defect Development Disease Ensure Environment Etiology Europe Explosion Fostering Future Genomic Instability Genomics Goals Health Human Inborn Genetic Diseases Incidence Inflammation Inherited International Intervention Investigation Link Location Malignant Neoplasms Metabolic Mutation Mutation Spectra Nerve Degeneration Neurologic New Mexico Oral Participant Pathway interactions Physiological Postdoctoral Fellow Predisposition Premature aging syndrome Process Publishing Reaction Reactive Oxygen Species Research Research Personnel Resort Role Scientist Series Site Source Students Techniques Translational Research Translations United States Uracil Work abstracting base cancer genome cancer therapy career genome sequencing human disease improved insight interest knowledge translation meetings new therapeutic target next generation novel oxidative DNA damage planetary Atmosphere posters programs public health relevance repaired research and development response symposium treatment strategy

项目摘要

DESCRIPTION (provided by applicant): The 5th US-EU Conference on Repair of Endogenous DNA Damage will be held in Santa Fe, New Mexico in November, 2014. The uniqueness of this series of meetings is its focus on the cellular responses to naturally formed genomic damage, and the relationship of defects in these responses to genetically inherited disorders associated with cancer predisposition, neurological deficits and premature aging. Understanding the contributions of endogenous DNA damage to human disease, in particular cancer, and the pathological changes associated with aging remains the major theme of this conference. Recently, there has been an explosion of information about the incidence and spectra of mutations in cancer genomes. These studies have revealed an unexpectedly large number of base substitutions, many of which are likely to be caused by persistent endogenous DNA damage. A major goal of this meeting is to foster collaborative research on the cellular processes that affect this type of genomic instability in cancer. The role of endogenous DNA damage, in particular oxidative DNA damage, as a driver of normal and accelerated aging and the study of premature aging syndromes remain important areas of interest. Insights from rare inherited human diseases with defects in the DNA damage response continue to illuminate links between endogenous DNA damage and cancer, aging and neurologic disease. To promote the translation of knowledge about the sources and repair of endogenous DNA lesions into interventions that improve global human health, this meeting will stimulate collaborative translational research focused on the identification of new therapeutic targets and the development of treatment strategies that either regulate DNA repair pathways in order to enhance cancer treatment or delay neurodegeneration, or reduce the pathological changes associated with aging. A key objective of the 2014 meeting is to provide an environment for both early career and senior investigators of diverse backgrounds to communicate their latest results on relevant scientific topics and establish future interactions that will not only strengthen the many basic science and translational research efforts in this arena, but also enhance the development of the next generation of researchers. Bishop's Lodge Ranch Resort and Spa is a high quality self-contained conference site that is located just outside the city of Santa Fe. This location will maximize interactions amongst participants, ensuring that the goal of promoting productive interactions between scientists in the US and EU is achieved.

描述（由申请人提供）：第五届美国欧盟内源性DNA损害修复会议将于2014年11月在新墨西哥州的圣达菲举行。这一系列会议的独特性是其对与遗传性疾病的缺陷及其与遗传性疾病的缺陷有关的自然形成基因组损害的蜂窝响应的重点。了解内源性DNA对人类疾病的贡献，尤其是癌症，以及与衰老相关的病理变化仍然是本次会议的主要主题。最近，关于癌症基因组突变的发生率和光谱的信息爆炸了。这些研究揭示了大量的基本取代，其中许多可能是由持续的内源性DNA损伤引起的。这次会议的主要目的是促进对影响癌症基因组不稳定性的细胞过程的合作研究。内源性DNA损伤的作用，特别是氧化DNA损伤，是正常和加速衰老的驱动因素以及对早熟衰老综合征的研究仍然是重要的感兴趣领域。来自罕见的遗传性人类疾病的见解继续在DNA损伤反应中继续阐明内源性DNA损伤与癌症，衰老和神经系统疾病之间的联系。为了促进有关内源性DNA病变的知识的翻译，将内源性DNA病变的知识转化为改善全球人类健康的干预措施，这次会议将刺激协作转化研究的重点是鉴定新的治疗靶标的识别和开发治疗策略，以调节DNA修复途径，以增强癌症治疗或延迟神经变性或与脂肪相关的神经变性。 2014年会议的一个关键目标是为早期职业和不同背景的高级调查人员提供一个环境，以传达其有关相关科学主题的最新结果，并建立未来的互动，不仅可以加强该领域的许多基础科学和翻译研究工作，还可以增强下一代研究人员的发展。 Bishop的Lodge Ranch Ranch Resort and Spa是一个高质量的独立会议地点，位于圣达菲市以外。这位置将最大程度地提高参与者之间的互动，以确保实现美国和欧盟科学家之间的生产互动的目标。