6th EU-US Conference on Repair of Endogenous DNA Damage

第六届欧盟-美国内源性DNA损伤修复会议

基本信息

批准号：
9329792
负责人：
Robert W Sobol
金额：
$ 0.5万
依托单位：
UNIVERSITY OF SOUTH ALABAMA
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-01 至 2018-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9329792
关键词：
Abnormal DNA Repair Address Affect Aging Alkylating Agents Appearance Area Basic Science Cell physiology Collaborations Complex DNA DNA Damage DNA Modification Process DNA Repair DNA Repair Pathway DNA lesion Defect Development Disease Ensure Environment Environmental Exposure Environmental Pollution Epigenetic Process Etiology Europe European Union Explosion Exposure to Fostering Genome Genome Stability Genomic Instability Genomics Goals Health Human Inborn Genetic Diseases Inflammation Inherited International Intervention Investigation Italy Knowledge Link Location Maintenance Malignant Neoplasms Metabolic Mutagens Nerve Degeneration Neurologic Deficit Oral Participant Pathologic Pathway interactions Physiological Postdoctoral Fellow Predisposition Premature aging syndrome RNA Reaction Reactive Oxygen Species Repair Complex Research Research Personnel Role Scientist Series Site Source Students Techniques Technology Time Translational Research Translations United States Universities Uracil cancer genome cancer therapy career collaborative environment genome editing human disease improved individualized prevention insight interest knowledge translation meetings nervous system disorder new technology new therapeutic target next generation novel oxidative DNA damage personalized approach planetary Atmosphere posters programs repaired research and development response symposium therapy development treatment strategy

项目摘要

Project Summary / Abstract The 6th US-EU Conference on Repair of Endogenous DNA Damage will be held September 24-28, 2017 in Udine, Italy. The uniqueness of this series of meetings is its focus on the cellular responses to naturally formed genomic damage, and the relationship of defects in these responses to genetically inherited disorders associated with cancer predisposition, neurological deficits and premature aging. Understanding the contributions of endogenous DNA damage to human disease, in particular cancer, and the pathological changes associated with aging is indeed the major theme of this conference. Recently, there has been an explosion-like increase of information on cancer genomes; the development of novel technologies for genome editing; visualizing DNA repair complexes; the role for RNA in genome stability; novel mechanisms of DNA repair and epigenetics; and the role of aging and environmental exposures in genome stability. A major goal of this meeting is to foster collaborative research on the cellular processes that affect genomic instability in cancer. The role of endogenous DNA damage, in particular oxidative DNA damage, as a driver of normal and accelerated aging and the study of premature aging syndromes remain important areas of interest. Insights from rare inherited human diseases with defects in the DNA damage response continue to illuminate links between endogenous DNA damage and cancer, aging and neurologic disease. To promote the translation of knowledge about the sources and repair of endogenous DNA lesions into interventions that improve global human health, this meeting will stimulate collaborative translational research focused on the identification of new therapeutic targets and the development of treatment strategies that either regulate DNA repair pathways in order to enhance cancer treatment, or delay neurodegeneration, or reduce the pathological changes associated with aging. A key objective of the 2017 meeting is to provide an environment for both early career and senior investigators of diverse backgrounds to communicate their latest results on relevant scientific topics and establish interactions that will not only strengthen the numerous basic science and translational research efforts in this arena, but also enhance the development of the next generation of researchers. The meeting will be held at the University of Udine, a venue chosen because it offers a unique informal interactive environment in the center of Europe. This location will maximize interactions amongst participants, ensuring that the goal of promoting productive interactions between scientists in the US and the European Union (EU) is achieved.

项目概要/摘要第六届美国-欧盟内源性DNA损伤修复会议将于2017年9月24-28日在美国举行意大利乌迪内。这一系列会议的独特之处在于其重点关注细胞对自然形成的反应基因组损伤，以及这些反应中的缺陷与相关遗传性疾病的关系具有癌症倾向、神经缺陷和过早衰老。了解的贡献内源性 DNA 损伤对人类疾病，特别是癌症以及与之相关的病理变化老龄化确实是本次会议的一大主题。最近一段时间爆发式增长有关癌症基因组的信息；基因组编辑新技术的开发； DNA可视化修复复合体； RNA 在基因组稳定性中的作用； DNA修复和表观遗传学的新机制；和衰老和环境暴露在基因组稳定性中的作用。本次会议的一个主要目标是促进关于影响癌症基因组不稳定性的细胞过程的合作研究。内源性的作用 DNA 损伤，特别是氧化性 DNA 损伤，作为正常和加速衰老的驱动因素，以及早衰综合症仍然是重要的关注领域。对罕见遗传性人类疾病的见解 DNA 损伤反应的缺陷继续阐明内源性 DNA 损伤与癌症之间的联系，衰老和神经系统疾病。促进有关来源和修复知识的翻译内源性 DNA 损伤转化为改善全球人类健康的干预措施，本次会议将刺激合作转化研究侧重于新治疗靶点的识别和开发调节 DNA 修复途径以增强癌症治疗或延迟的治疗策略神经退行性变，或减少与衰老相关的病理变化。 2017年的主要目标会议的目的是为不同背景的早期职业和高级研究人员提供一个环境交流他们在相关科学主题上的最新成果并建立互动，这不仅会加强这一领域的众多基础科学和转化研究努力，也促进了该领域的发展下一代研究人员。会议将在乌迪内大学举行，选择这个地点是因为它在欧洲中心提供了独特的非正式互动环境。这个位置将最大化互动参与者之间，确保促进美国和美国科学家之间富有成效的互动的目标欧盟（EU）已实现。