RTI's Regional Comprehensive Metabolomics Resource Center

RTI 区域综合代谢组学资源中心

• 批准号: 8894895
• 负责人: SUSAN J SUMNER
• 金额: $ 5万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-04 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8894895
• 关键词: Area; Businesses; Chemicals; Client; Clinical Investigator; Clinical Research; Collaborations; Commit; Communities; Consensus; Consult; Contracts; Data; Data Analyses; Data Collection; Data Quality; Databases; Deposition; Development; Dietary Intervention; Ensure; Exposure to; Feasibility Studies; Fees; Fostering; Funding; Gas Chromatography; Goals; Growth; International; Laboratories; Lead; Leadership; Learning; Manuscripts; Maps; Mass Fragmentography; Methods; Multivariate Analysis; NMR Spectroscopy; Nonprofit Organizations; North Carolina; Nuclear Magnetic Resonance; Online Systems; Onset of illness; Pathway interactions; Pharmaceutical Preparations; Pilot Projects; Preparation; Publications; Qualifying; Reporting; Research; Research Institute; Research Training; Resolution; Resources; Scientist; Senior Scientist; Services; System; Technology; Therapeutic Intervention; Training Programs; Training and Education; Universities; Work; base; data sharing; design; environmental stressor; investigator training; liquid chromatography mass spectrometry; metabolomics; new technology; novel strategies; outreach; response; sample collection; tool; web site

DESCRIPTION (provided by applicant): The goal of the RTI International (RTI) RCMRC is to develop a self-sustaining regional metabolomics center that offers a comprehensive range of services at reasonable fees and collaborative opportunities designed to maintain and develop state-of-the-art standardized methods, and to promote research, training, and education in metabolomics to increase the number of trained investigators and to expand the use of metabolomics technologies. The RTI RCMRC will work in a consortium to establish nationwide standards that will serve to provide consistency in the metabolomics data collected and stored in a central Data Repository and Coordinating Center (DRCC).The RTI RCMRC will be led by RTI, whose qualified and committed senior scientists will contribute to and oversee five Cores: Administrative Core A; Liquid Chromatography-Mass Spectrometry Metabolomics Core B; Gas Chromatography-MS Metabolomics Core C; NMR Spectroscopy Metabolomics Core D; and Promotion and Outreach Core E. RTI is an independent nonprofit, organization, established in 1958 in Research Triangle Park (RTP), North Carolina (NC), and is governed by the University of North Carolina System, by Duke University, and by the NC business community. RTI will facilitate the business development activities to achieve the long-range goals of growth and sustainability. The Administrative Core will provide oversight to all center activities and foster interactions among RTI and our collaborators. The RTI RCMRC is supported by our collaboration with the David H. Murdock Research Institute, and with three internationally recognized metabolomics scientists (Drs. Jeremy Nicholson, Elaine Holmes, and Ian Wilson) who will consult on all aspects of this center. The three technology cores will develop and apply metabolomics methods to support collaborative and client-based studies aimed at understanding perturbations in the metabolome that arise as a result of exposure (to chemicals, drugs, environmental stressors), disease onset, progression, resolution, or therapeutic or nutritional intervention. The Promotion and Outreach Core will develop web-based learning tools, increase the number of interns in the metabolomics training program, and disseminate promotional materials.

描述（由申请人提供）：RTI International（RTI）RCMRC的目标是开发一个自我维持的区域代谢组学中心，该中心以合理的费用和旨在维护和开发最先进的合作机会提供全面的服务，以合理的费用和协作机会 - 用于促进代谢组学的研究，培训和教育以增加训练有素的研究人员的数量并扩大代谢组学技术的使用。 RTI RCMRC将在一个财团中工作，以建立全国范围的标准，该标准将提供在中央数据存储库中收集和存储的代谢组学数据的一致性。RTIRCMRC将由RTI领导，其合格，承诺，并承诺，并承诺高级科学家将为五个核心做出贡献：行政核心A；液相色谱 - 质谱法代谢组学核心B；气相色谱-MS代谢组学核心C； NMR光谱代谢组学核心D；促销和外展核心E. RTI是一家独立的非营利组织，该组织成立于1958年，在北卡罗来纳州的研究三角公园（RTP）（NC）成立，由北卡罗来纳大学系统，杜克大学，由北卡罗来纳大学和大学管理。 NC商业界。 RTI将促进业务发展活动，以实现增长和可持续性的远程目标。行政核心将对RTI和我们的合作者之间的所有中心活动和培养互动提供监督。 RTI RCMRC得到了我们与David H. Murdock Research Institute的合作，并与三位国际认可的代谢组学科学家（Jeremy Nicholson博士，Elaine Holmes和Ian Wilson博士）的支持，他们将就该中心的各个方面进行咨询。这三种技术核心将开发和采用代谢组学方法来支持基于协作和客户的研究，旨在了解由于暴露（化学物质，药物，环境压力源），疾病发作，进展，分辨率或分辨率，或治疗或营养干预。促销和外展核心将开发基于网络的学习工具，增加代谢组学培训计划中实习生的数量，并传播促销材料。