Center for Leadership in Environmental Awareness and Research

环境意识和研究领导力中心

基本信息

批准号：
10352961
负责人：
Carol Jean Miller
金额：
$ 227.06万
依托单位：
WAYNE STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-08 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10352961
关键词：
Address Adverse effects Affect Aging Americas Animal Model Awareness Bayesian Modeling Behavioral Benzene Biological Biological Assay Biological Markers Biomedical Research Birth Birth Rate Businesses Chemicals Child Health Cities Collaborations Communities Complex Computing Methodologies Country Data Data Analyses Detection Development Documentation Education Engineering Ensure Environmental Engineering technology Environmental Health Environmental Pollution Environmental Science Epidemiologic Methods Etiology Exposure to Faculty Fetal health Gases Great Lakes Region Hazardous Substances Health Health system Home Human Immune Immunologics Industrialization Inflammation Inflammatory Response Infrastructure Institution Internet of Things Intervention Knowledge Laboratories Leadership Life Link Maps Maternal Health Methodology Methods Michigan Minority Groups Modeling Neurologic Outcome Participant Pathway interactions Phase Placenta Plant Roots Plants Play Predisposition Pregnancy Outcome Premature Birth Property Public Health Reporting Research Research Activity Research Project Grants Risk Risk Assessment Role Sampling Schools Science Scientist Site Soil Specimen Superfund System Targeted Research Techniques Technology Testing Tetrachloroethylene Time Tissues Toluene Toxic effect Toxicant exposure Training Translating Translational Research Translations Trichloroethylene Universities Visualization software Workplace Xylene Zebrafish adverse birth outcomes biological systems built environment college community engagement cost data management design ethylbenzene experience exposed human population exposure pathway exposure route ground water improved innovation landfill mouse model next generation novel offspring pollutant pregnant prevent programs public health emergency public health intervention real time model remediation reproductive research and development residence response risk mitigation seal sensor technology superfund site urban area urban setting vapor vapor intrusion volatile organic compound

项目摘要

Abstract: Evidence suggests that exposure to volatile organic compounds (VOCs), such as benzene, toluene, ethylbenzene, and xylene (BTEX), trichloroethylene (TCE), and tetrachloroethylene (PCE), is an important determinant of maternal-offspring health, with implications for preterm birth (PTB) and associated adverse health outcomes. VOCs emanate from landfills, brownfields, and Superfund sites, contaminating shallow soils and groundwater below residential, commercial, and industrial properties, leading to exposures via vapor intrusion. The Center for Leadership in Environmental Awareness and Research (CLEAR) is dedicated to understanding and mitigating this serious environmental health problem with a focus on post-industrial urban centers. Headquartered in Detroit, Michigan, CLEAR will use Detroit as a study site, which has the highest PTB rate in the country (15.2%) and is located in a state where 37 of the 67 Superfund sites must manage VOC contamination. CLEAR hypothesizes that VOC exposure through vapor intrusion during early life incites inflammatory responses in maternal tissues and/or the developing offspring that re-program the developing immune and other critical systems, setting the stage for PTB and/or associated adverse health outcomes. Five integrative environmental science and engineering and biomedical research projects (E1, E2, B1, B2, B3), supported by five cores, will investigate toxic mechanisms, exposure pathways, biomarkers, and strategies to prevent exposures and improve public health outcomes by: (1) developing and testing new detection methodologies, including phytoscreening (E1); sensor technology that integrates Internet of Things and edge computing for real-time contaminant detection and rapid-response, mitigation, and remediation (E2); and a controlled toxicity bioassay using WSU-designed sealed chambers for evaluating reproductive, neurological, behavioral, immunological and multigenerational responses in zebrafish (B1); (2) studying mechanistic effects of VOC exposure in a pregnant mouse model (B2); (3) applying epidemiologic methods for estimating exposure effects via human biological specimen analysis (B3); applying advanced chemical analysis, statistical approaches and visualization tools to obtain and integrate project data (Chemical Analysis, and Data Management and Analysis Cores), thereby establishing the impact of VOC exposures on PTB and associated adverse health outcomes; (4) creating an innovative model for transdisciplinary education and workforce diversity by engaging new trainees to solve complex environmental health problems (Research Experience and Training Coordination Core); (5) engaging stakeholders and the community to inform our inquiry/analysis, participate in sampling, and employ health interventions (Community Engagement Core); and (6) uniting around an Administrative Core that conducts targeted research translation to ensure a legacy of scientific awareness and supports the Superfund Research Program to improve public health in urban centers impacted by environmental contamination to protect affected communities.

摘要：有证据表明，接触挥发性有机化合物（VOC），如苯、甲苯、乙苯、二甲苯（BTEX）、三氯乙烯（TCE）和四氯乙烯（PCE）是重要的母子健康的决定因素，对早产（PTB）和相关不良影响有影响健康结果。挥发性有机化合物来自垃圾填埋场、棕地和超级基金场地，污染浅层土壤以及住宅、商业和工业地产下方的地下水，导致通过蒸气暴露入侵。环境意识与研究领导力中心 (CLEAR) 致力于了解并缓解这一严重的环境健康问题，重点关注后工业城市中心。总部位于密歇根州底特律的 CLEAR 将使用 PTB 最高的底特律作为研究地点该国的比率 (15.2%)，并且位于 67 个超级基金站点中有 37 个必须管理 VOC 的州污染。 CLEAR 假设生命早期通过蒸汽侵入接触 VOC 会引发母体组织和/或发育中的后代中的炎症反应会重新编程发育中的后代免疫系统和其他关键系统，为 PTB 和/或相关不良健康结果奠定基础。五环境科学与工程与生物医学综合研究项目（E1、E2、B1、B2、B3）、由五个核心支持，将研究毒性机制、暴露途径、生物标志物和策略通过以下方式预防暴露并改善公共卫生结果：(1) 开发和测试新的检测方法方法，包括植物筛选（E1）；物联网与边缘融合的传感器技术用于实时污染物检测和快速响应、缓解和修复的计算（E2）；和一个使用 WSU 设计的密封室进行受控毒性生物测定，用于评估生殖、神经、斑马鱼的行为、免疫和多代反应（B1）； (2)研究机械效应怀孕小鼠模型中 VOC 暴露的影响 (B2)； (3)应用流行病学方法进行估算通过人体生物样本分析得出的暴露影响（B3）；应用先进的化学分析、统计获取和集成项目数据（化学分析和数据）的方法和可视化工具管理和分析核心），从而确定 VOC 暴露对 PTB 和相关的影响不良健康后果；（4）创建跨学科教育和劳动力的创新模式通过让新学员解决复杂的环境健康问题来实现多样性（研究经验和培训协调核心）； (5) 让利益相关者和社区参与我们的调查/分析，参与采样并采取健康干预措施（社区参与核心）； (6) 团结围绕一个行政核心进行有针对性的研究翻译，以确保科学遗产意识并支持超级基金研究计划，以改善受影响城市中心的公共卫生通过环境污染来保护受影响的社区。