Center for Dietary Supplements and Inflammation

膳食补充剂和炎症中心

基本信息

批准号：
8733726
负责人：
Prakash S Nagarkatti
金额：
$ 203.23万
依托单位：
UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-01 至 2017-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8733726
关键词：
Adaptor Signaling Protein Adhesions Advisory Committees American Anti-Inflammatory Agents Anti-inflammatory Antiatherogenic Area Arterial Fatty Streak Atherosclerosis Attenuated Autoimmune Diseases Award Binding Blood Vessels Botanicals Brain Cardiovascular Diseases Cells Centers of Research Excellence China Chinese Herbs Chinese Traditional Medicine Chronic Clinic Clinical Clinical Trials Complement Complementary and alternative medicine Core Facility Data Deposition Development Diet Disease Endothelial Cells Entrepreneurship Faculty Fatty acid glycerol esters Goals Grant Heart Herb Human In Vitro Infiltration Inflammation Inflammatory Inflammatory Response Interdisciplinary Study Interleukin-1 Invaded Investigation Lead Leukocytes Ligands Lipids Lipopolysaccharides Low Density Lipoprotein Receptor Malignant Neoplasms Measures Mediating Mentors Modality Molecular Mus Myocardial Infarction Natural Immunity Neurodegenerative Disorders Pathogenesis Pharmacology Phenotype Plants Play Proteins Recruitment Activity Research Research Personnel Research Project Grants Role Scientist Signal Transduction Smooth Muscle Myocytes South Carolina Staging Stroke Structure TLR2 gene TLR3 gene TLR4 gene Testing Therapeutic Therapeutic Agents Tissues Toll-like receptors Training Translational Research United States Universities Vascular Endothelial Cell Viral Work analog atherogenesis base cell motility dietary supplements driving force feeding hypercholesterolemia immune function innovation macrophage member monocyte novel oxidized lipid pathogen prevent programs public health relevance receptor vascular inflammation

项目摘要

DESCRIPTION (provided by applicant): This COBRE application proposes to establish a Center for Dietary Supplements and Inflammation (CDSI) at the University of South Carolina (USC) that will pursue multidisciplinary research on how botanicals can modulate inflammation and be used to prevent and/or treat inflammatory diseases. Recently, USC has made significant strides to promote research in Complementary and Alternative Medicine (CAM) which has resulted in the award of a Program Project/Center grant to study CAM modalities to treat autoimmune diseases. Thus, the CDSI will complement the CAM program and create a unique niche at USC in inflammation research. The main goal of CDSI is to establish multi-disciplinary research that will identify the molecular mechanisms through which botanicals modulate inflammation so that they or their analogs can be used to prevent and/or treat inflammatory diseases. Americans spend~$33.9 billion/year on CAM, of which ~$20 billion is on dietary supplements. It is becoming increasingly clear that inflammation plays a critical role in the pathogenesis of not only autoimmune diseases but also a wide range of clinical disorders including cardiovascular diseases, neurodegenerative disorders, and cancer: areas under investigation in this study. Thus, understanding the mode of action of dietary supplements or their constituents on inflammation, could lead to novel treatment modalities with far ranging clinical implications. The CDSI goal will be accomplished through promotion of multi-disciplinary research pursued by 4 junior tenure-track faculty in the area of inflammatory diseases, through highly structured mentoring by eight senior faculty members, and providing them with state-of-the-art core facilities. The program will be evaluated by an External Advisory Committee consisting of nationally recognized scientists. Additionally, through institutional support, 10 new tenure-track junior faculty will be recruited and trained at USC to bolster and advance inflammation research. The long term objective of the CDSI would be to build a self-sustaining, nationally recognized multi-disciplinary Center for dietary supplements and inflammation research, by promoting innovation, faculty entrepreneurship, collaborative research projects (PPGs and Institutional Training grants), and clinical/translational research.

描述（由申请人提供）：该牢固的申请建议在南卡罗来纳大学（USC）建立饮食补充剂和炎症（CDSI）中心，该中心将对植物学者如何调节炎症并被用于预防炎症性疾病，从事多学科研究。最近，南加州大学取得了长足的进步，以促进互补和替代医学（CAM）的研究，这导致授予了计划/中心赠款的授予，以研究治疗自身免疫性疾病的CAM模式。因此，CDSI将补充CAM计划，并在USC炎症研究中创建独特的利基市场。 CDSI的主要目标是建立多学科研究，以确定植物体调节炎症的分子机制，以便它们或其类似物可用于预防和/或治疗炎症性疾病。美国人在CAM上花费约339亿美元/年，其中约200亿美元用于饮食补充剂。越来越清楚的是，炎症在不仅自身免疫性疾病的发病机理中起着至关重要的作用，而且在这项研究中研究了多种临床疾病，包括心血管疾病，神经退行性疾病和癌症：正在研究的地区。因此，了解饮食补充剂或其成分对炎症的作用方式，可能会导致新的治疗方式具有较大的临床意义。 CDSI目标将通过促进由4个初级终身教师在炎症性疾病领域进行的多学科研究，通过八名高级教职员工的高度结构化指导，并为他们提供最先进的核心设施。该计划将由由国家认可的科学家组成的外部咨询委员会评估。此外，通过机构支持，10个新终身制初级教师将在南加州大学招募和培训，以增强和推动炎症研究。 CDSI的长期目标是建立一个自我维持的，全国认可的饮食补充剂和炎症研究中心，通过促进创新，教职企业家精神，协作研究项目（PPGS和机构培训授课）以及临床/转化研究。