Modulation of Erythropoiesis During Salmonella Infection

沙门氏菌感染期间红细胞生成的调节

基本信息

批准号：
8486486
负责人：
STEPHEN J MCSORLEY
金额：
$ 18.33万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-01 至 2014-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8486486
关键词：
Affect Anti-Inflammatory Agents Anti-inflammatory Area Attention Bacteria Bacterial Infections Bone Marrow Cell Nucleus Cell surface Cells Cessation of life Clinical Communicable Diseases Data Dendritic Cells Development Dialysis procedure Disease Erythrocytes Erythroid Erythroid Progenitor Cells Erythropoiesis Erythropoietin Erythropoietin Receptor Gastroenteritis Generations Goals Growth Human Immune Immune response Immune system Infection Laboratories Lead Mus Natural Immunity Patients Play Population Production Receptor Signaling Recombinant Erythropoietin Regulation Research Role Salmonella Salmonella enterica Salmonella infections Salmonella typhimurium Sanitation Spleen Splenomegaly Staging System Systemic infection TLR4 gene Testing Toll-like receptors Typhoid Fever Water adaptive immunity base chemotherapy cytokine in vivo macrophage mouse model novel therapeutics novel vaccines response

项目摘要

DESCRIPTION (provided by applicant): Erythropoietin (EPO) plays a central role in regulating erythroid development and recombinant EPO is widely used in patients to treat erythropoietic insufficiency. However, very little is known about the effect of EPO on non-erythroid cells. We recently found that Salmonella infection induces EPO production and erythroid expansion and that this has a beneficial effect on bacterial growth in vivo. Together, these data suggest a surprising level of crosstalk between the immune response to bacterial infection and the homeostatic regulation of erythroid development. Our goal in this exploratory application is to study this important new research area in more detail. Given the novelty and potential importance of erythroid-immune interactions, we believe greater understanding of this area could lead to the generation of new vaccines and therapeutics for bacterial infections. Our application specifically proposes to, (i) identify the cell population and bacterial products responsible for EPO production during infection, and (ii) examine whether EPO has direct and indirect effects on the immune response to infection. Overall, our proposal bridges two well-developed, but disconnected, research fields and is likely to have broader implications for understanding how erythroid development impacts immune responses to infectious disease.

描述（由申请人提供）：促红细胞生成素（EPO）在调节红细胞发育和重组EPO方面起着核心作用，可在患者中广泛用于治疗促红细胞生成不足。然而，对于EPO对非果蝇细胞的影响知之甚少。我们最近发现，沙门氏菌感染会诱导EPO产生和红细胞扩张，这对体内细菌生长具有有益作用。总之，这些数据表明对细菌感染的免疫反应与红斑发育的稳态调节之间的串扰水平令人惊讶。我们在探索性应用中的目标是更详细地研究这个重要的新研究领域。鉴于红斑 - 免疫相互作用的新颖性和潜在的重要性，我们认为对这一领域的更多了解可能会导致新的疫苗和细菌感染的治疗剂的产生。我们的应用专门提议（i）确定在感染过程中负责EPO产生的细胞群和细菌产品，以及（ii）检查EPO对感染免疫反应是否直接和间接影响。总体而言，我们的提案桥梁桥梁两个完善但已断开的研究领域，可能对了解红细胞发育如何影响对传染病的免疫反应具有更广泛的影响。