Biostatistics

生物统计学

• 批准号: 8235358
• 负责人: DONNA S. NEUBERG
• 金额: $ 18.33万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-12-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8235358
• 关键词: Advisory Committees; Biometry; Biostatistics Core; Chronic Lymphocytic Leukemia; Clinical; Clinical Research; Clinical Trials; Clinical Trials Data Monitoring Committees; Communities; Correlative Study; Data; Databases; Disease; Hand; Instruction; Investigation; Laboratories; Laboratory Study; Mus; Process; Research; Research Personnel; Sampling; Teleconferences; Tissues; Work; design; improved; meetings; member; quality assurance; research study; sound

PROJECT SUMMARY (See instructions): CORE B (Biostatistics) The Biostatistics Core (Core B) seeks to assure that all CRC investigators have access to state-of-the-art biostatistical support for all aspects of the design and conduct of their investigations. Specific Aim 1: To provide collaborative statistical support for investigations conducted by the members of the CLL Research Consortium (CRC) 1.1 To provide statistical support for the clinical research studies conducted by the CRC. 1.2 To provide statistical support for the laboratory studies conducted by the CRC, including both freestanding studies within the Projects and laboratory correlative studies embedded in the clinical trials. 1.3 To provide statistical support for murine studies conducted by the Projects. Specific Aim 2: To participate in the quality assurance and quality improvement processes for the CRC database 2.1 To participate in an ongoing process of quality improvement for the CRC database. 2.2 To advise on quality assurance as new types of data are incorporated into the CRC database. Specific Aim 3; To participate in the scientific advisory committees of the CRC 3.1 To participate in teleconferences and meetings held by the Clinical Advisory Committee, the Scientific Advisory Committee, and the Data Safety and Monitoring Board. 3.2 To participate in the review of all sample requests submitted to the Tissue Core (Core C). Specific Aim 4: To provide a forum for statisticians working in CLL 4.1 To provide, through the distributed Biostatistics Core, a forum for statisticians working in CLL to improve their understanding of the disease and thereby provide even better statistical support to the Projects.

项目摘要（请参阅说明）： 核心B（生物统计学） 生物统计学核心（核心B）试图确保所有CRC研究人员都可以访问针对其研究的各个方面的最先进的生物统计学支持。 具体目的1：为CLL研究联盟（CRC）成员进行的调查提供协作统计支持 1.1为CRC进行的临床研究提供统计支持。 1.2为CRC进行的实验室研究提供统计支持，包括项目中的独立研究和嵌入临床试验中的实验室相关研究。 1.3为项目进行的鼠研究提供统计支持。 特定目标2：参与CRC数据库的质量保证和质量改进过程 2.1参与CRC数据库质量改进的过程。 2.2为质量保证提供建议，因为将新类型的数据纳入了CRC数据库。 具体目标3;参加CRC的科学咨询委员会 3.1参加临床咨询委员会，科学咨询委员会以及数据安全与监测委员会举行的电信和会议。 3.2参与提交给组织核心（核心C）的所有样本请求的审查。 特定目标4：为在CLL工作的统计学家提供论坛 4.1通过分布式生物统计学核心提供一个在CLL工作的统计学家的论坛，以提高对疾病的理解，从而为项目提供更好的统计支持。