Core 2: Biocomputational and Biostatistics Core

核心2：生物计算和生物统计学核心

基本信息

批准号：
10210227
负责人：
DONNA S. NEUBERG
金额：
$ 21.64万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-03 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10210227
关键词：
Address Algorithms Animal Experiments Animal Model Animals B-Lymphocytes Basic Science Biological Assay Biometry Biostatistics Core Cell Communication Cell Line Cell Nucleus Cells Clinical Clinical Research Clinical Trials Clonality Clone Cells Correlative Study Data Data Analyses Ensure Experimental Designs Genes Genetic Genetic Variation Genomics Glioblastoma Goals Human Immunosuppression Immunotherapy Individual Intervention Investigation Laboratories Lead Maps Measurement Mus Noise Non-Malignant Patients Peer Review Physiological Process Reproducibility Resources Scheme Specimen T-Cell Activation T-Lymphocyte Techniques Variant Visualization Work attenuation biocomputing cell type clinically relevant computational pipelines computerized data processing data sharing design experimental study genetic manipulation human data immunological intervention insight laboratory experiment mouse model power analysis predicting response profiles in patients programs single-cell RNA sequencing transcriptome sequencing treatment response tumor tumor-immune system interactions

项目摘要

PROJECT SUMMARY/ABSTRACT—Core 2 Biocomputation and Biostatistics The purpose of Core 2 Biocomputation and Biostatistics is to provide computational and statistical support to the four Projects in this P01, and to collaborate with Cores to provide to address such computational and biostatistical needs as required to accommodate the needs of the projects. This assures that the design, conduct, and analyses of all experiments—clinical, correlative, animal, or basic science--use robust statistical techniques that are appropriately implemented, and that the specialized resources to analyze and interpret single cell RNA sequencing results are available to the projects on a priority basis, for cells from clinical trial patients, from cell lines developed from those patients, and from murine experiments.. This central resource thereby helps to elucidate the changes in T cell activation and attenuation that result from immunologic interventions in GBM.

项目摘要/摘要 - 核2生物制和生物统计学 Core 2生物成绩和生物统计学的目的是提供计算和统计支持在本P01中的四个项目中，并与核心合作以解决此类计算和需要根据需要的生物统计需求来满足项目的需求。这是假设设计的对所有实验（临床，相关，动物或基础科学）的行为和分析 - 使用强大的统计适当实施的技术以及分析和解释的专门资源单细胞RNA测序结果优先用于项目，用于临床试验的细胞患者，来自这些患者和鼠实验的细胞系。从而有助于阐明免疫学引起的T细胞激活和衰减的变化 GBM的干预措施。