Core 2: Biocomputational and Biostatistics Core

核心2：生物计算和生物统计学核心

• 批准号: 10477996
• 负责人: DONNA S. NEUBERG
• 金额: $ 21.21万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-03 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10477996
• 关键词: Address; Algorithms; Animal Experiments; Animal Model; Animals; B-Lymphocytes; Basic Science; Biological Assay; Biometry; Biostatistics Core; Cell Communication; Cell Line; Cell Nucleus; Cells; Classification; Clinical; Clinical Research; Clinical Trials; Clonality; Clone Cells; Correlative Study; Data; Data Analyses; Ecosystem; Ensure; Experimental Designs; Genes; Genetic; Genetic Variation; Genomics; Glioblastoma; Goals; Human; Immunosuppression; Immunotherapy; Individual; Intervention; Investigation; Laboratories; Lead; Maps; Measurement; Mus; Noise; Non-Malignant; Patients; Peer Review; Physiological; Process; Reproducibility; Resources; Scheme; Specimen; T-Cell Activation; T-Lymphocyte; Techniques; Variant; Visualization; Work; attenuation; biocomputing; cell type; clinically relevant; computational pipelines; computerized data processing; data sharing; design; experimental study; genetic manipulation; human data; immunological intervention; insight; laboratory experiment; mouse model; power analysis; predicting response; profiles in patients; programs; single-cell RNA sequencing; transcriptome sequencing; treatment response; tumor; tumor-immune system interactions

PROJECT SUMMARY/ABSTRACT—Core 2 Biocomputation and Biostatistics The purpose of Core 2 Biocomputation and Biostatistics is to provide computational and statistical support to the four Projects in this P01, and to collaborate with Cores to provide to address such computational and biostatistical needs as required to accommodate the needs of the projects. This assures that the design, conduct, and analyses of all experiments—clinical, correlative, animal, or basic science--use robust statistical techniques that are appropriately implemented, and that the specialized resources to analyze and interpret single cell RNA sequencing results are available to the projects on a priority basis, for cells from clinical trial patients, from cell lines developed from those patients, and from murine experiments.. This central resource thereby helps to elucidate the changes in T cell activation and attenuation that result from immunologic interventions in GBM.