University of Washington Urologic Chronic Pelvic Pain Syndromes Discovery Center

华盛顿大学泌尿科慢性盆腔疼痛综合征发现中心

基本信息

批准号：
8334701
负责人：
DEDRA S BUCHWALD
金额：
$ 87.68万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-15 至 2014-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8334701
关键词：
Accounting Address Adopted Adult Affect Basic Science Biochemical Bioinformatics Biological Biological Markers Bladder Chronic Chronic Fatigue Syndrome Chronic Prostatitis Clinic Clinical Clinical Research Clinical Sciences Communities Controlled Study Data Development Diabetes Mellitus Diagnosis Digestive System Disorders Discipline Disease Dizygotic Twins Early Diagnosis Employee Strikes Enrollment Environment Environmental Exposure Environmental Risk Factor Epidemiologic Studies Epidemiology Etiology Event Female Foundations Functional disorder Funding Future Genetic Genotype Goals Guidelines Heritability Institutes Interstitial Cystitis Investigation Kidney Diseases Lead Learning Link Methods Modeling Molecular Monozygotic Twinning Monozygotic twins National Institute of Diabetes and Digestive and Kidney Diseases Natural History Neurobiology Neurogenic Inflammation Pain Participant Patients Pelvis Peptides Perception Phenotype Population Study Positioning Attribute Post-Traumatic Stress Disorders Predisposing Factor Predisposition Prevention Prevention strategy Program Research Project Grants Prostate Proteins Proteomics Protocols documentation Registries Relative (related person)Request for Applications Research Research Design Research Personnel Risk Role Sampling Severities Site Specimen Staging Survey Methodology Surveys Symptoms Syndrome System Techniques Technology Testing Theoretical model Tissues Translating Translational Research Trauma Twin Multiple Birth Twin Studies U-Series Cooperative Agreements United States National Institutes of Health Universities Up-Regulation Urothelial Cell Victimization Washington Woman Work base chronic pain chronic pelvic pain clinical care disease diagnosis disease natural history disease phenotype flexibility follow-up functional status genetic risk factor insight male men multidisciplinary neurophysiology novel strategies outcome forecast patient population population based psychosocial relating to nervous system response success tandem mass spectrometry treatment strategy urologic

项目摘要

This proposal responds to RFA of -DK-07-003, which requests applications for Discovery Centers to collaborate with other Discovery Centers in a Multi-Disciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. In this application, the University of Washington (UW) seeks support for a Discovery Center to participate in efforts to unravel the enigma of what has been termed urologic chronic pelvic pain syndromes (UCPPS) by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). This proposal was developed following the guidelines stipulated by the NIDDK for Program Project Grants and Cooperative Agreements. The aims of these Discovery Centers, in conjunction with the Tissue Analysis and Technology Core and the Data Coordination Core, are to conduct multi-disciplinary, multi-site, basic, translational, and clinical research in the field of UCPPS. The goals of the MAPP Research Network are to 1) identify UCPPS disease phenotypes; 2) determine how UCPPS fit into the larger spectrum of related chronic pain syndromes (RCPS); 3) conduct targeted epidemiological studies of UCPPS using relevant patient populations; and 4) use basic cellular, molecular, and biochemical techniques to examine the pathophysiology of UCPPS. More broadly, each site will need to collaborate closely with NIDDK staff and other Network Centers to complete multidisciplinary, multi-site, and highly interactive studies, and to obtain specimens for basic science studies. In addition, Discovery Centers will need the flexibility to accept and implement new and perhaps unconventional UCPPS definitions, and to both import and export study designs and methods pertinent to UCPPS.

该建议对-DK-07-003的RFA做出响应，该RFA要求发现中心的申请与其他发现中心合作，以多学科的方法进行多学科研究，以研究慢性骨盆疼痛（MAPP）研究网络。在此应用程序中，华盛顿大学（UW）寻求对发现中心的支持，以参与努力揭示所谓的泌尿科慢性骨盆疼痛综合症（UCPPS）的谜，该研究所由美国国家糖尿病研究所，消化和肾脏疾病和肾脏疾病（NIDDK）。该提案是根据NIDDK规定的计划项目赠款和合作协议规定的指南制定的。这些发现中心的目的以及组织分析和技术核心以及数据协调核心的目的是在UCPPS领域进行多学科，多站点，基本，转化和临床研究。 MAPP研究网络的目标是1）识别UCPPS疾病表型； 2）确定UCPP如何适应较大的相关慢性疼痛综合征（RCP）； 3）使用相关患者人群对UCPP进行针对性的流行病学研究； 4）使用基本的细胞，分子和生化技术检查UCPP的病理生理学。更广泛地说，每个站点都需要与NIDDK员工和其他网络中心密切合作，以完成多学科，多站点和高度互动的研究，并获得基础科学研究的标本。此外，发现中心将需要灵活性来接受和实施新的，也许是非常规的UCPP定义，以及与UCPP有关的进口和出口研究设计和方法。