Natives Engaged in Alzheimer's Research

参与阿尔茨海默氏症研究的当地人

• 批准号: 10459235
• 负责人: DEDRA S BUCHWALD
• 金额: $ 293.82万
• 依托单位: WASHINGTON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10459235
• 关键词: Address; Adherence; Age; Alaska Native; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American Indians; Area; Awareness; Behavior Therapy; Behavioral Sciences; Blood specimen; Cataloging; Catalogs; Cholesterol; Clinic; Clinical; Clinical Sciences; Collection; Communities; Community Healthcare; DNA; Data; Dementia; Detection; Economic Burden; Economics; Elderly; Ensure; Family; Frequencies; Genetic Markers; Genetic Research; Genotype; Goals; Hawaiian; Health; Health Benefit; Healthcare Systems; High Prevalence; Hypertension; Impaired cognition; Indian reservation; Intervention; Island; Knowledge; Leadership; Life Expectancy; Minnesota; National Institute on Aging; Native Hawaiian; Native Hawaiian or Other Pacific Islander; Native-Born; Neighborhood Health Center; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Observational Study; Obstructive Sleep Apnea; Patients; Persons; Physical activity; Population; Provider; Public Health; Quality of life; Randomized Controlled Trials; Research; Research Methodology; Research Personnel; Research Priority; Research Project Grants; Resources; Rural; Saliva; Sampling; Sleep Apnea Syndromes; Smoking; Social Sciences; Special Population; Testing; Training; Translating; Underrepresented Minority; Universities; Washington; Work; base; cognitive function; cohort; community partnership; dementia risk; disparity elimination; disparity reduction; effective intervention; effectiveness testing; experience; genetic risk factor; health disparity; high risk; improved; innovation; interest; low socioeconomic status; mild cognitive impairment; native elder; polygenic risk score; preservation; prevent; programs; public health research; randomized trial; recruit; repository; saliva sample; social; tribal community

OVERALL: ABSTRACT American Indians/Alaska Natives (AI/ANs) and Native Hawaiians and Pacific Islanders (NHPIs) are increasingly concerned about Alzheimer’s disease and related dementias, as these conditions will soon have a major impact on their communities. Although AI/ANs and NHPIs share a high prevalence of ADRD risk factors, including hypertension and type 2 diabetes, their life expectancies have improved by as much as 30 years over the last 5 decades, resulting in a tripling of their populations’ share of people ages 65+. Unfortunately, the healthcare systems that serve AI/ANs and NHPIs are unprepared for the clinical, social, and economic, burdens associated with ADRD. The Natives Engaged in Alzheimer’s Research Center will be the only P01 to include AI/ANs or Native Hawaiians since the National Institute on Aging started cataloging P01s in 1984. Based at Washington State University, with collaborators at the University of Miami, Brigham Young University, and several other major universities, as well as with AI/AN and NHPI community partners, we will create an innovative program to understand, intervene on, and mitigate ADRD-related health disparities experienced by our priority populations. Our 3 Research Projects will be supported by Administrative, Research Methods, Recruitment and Engagement, and Biospecimen Cores. The Center will also feature a network of 8 Satellite Centers led by Native researchers that encompass areas where 90% of AI/ANs and NHPIs reside. These Satellite Centers will ensure that our work and our dissemination efforts are national in scope and help to create research-ready cohorts. The Center will unite scholars across social, clinical, and behavioral sciences. Notably, 12 AI/AN or NH/PI professionals have committed to participate as Investigators or Consultants. Thus, our Specific Aims are to: 1) In a group- randomized trial, test the effectiveness of a culturally informed provider training and “dementia-friendly clinic” intervention for detection and appropriate management of AI/AN patients with ADRD and mild cognitive impairment in at least 20 urban and rural clinics serving AI/ANs; 2) In a group-randomized controlled trial, test the effectiveness of a Hula intervention for preventing cognitive decline in NHPI elders with subjective cognitive impairments or mild cognitive impairment in the Hawaiian Islands; 3) In an observational study, screen AIs in 2 remote reservation communities for obstructive sleep apnea and cognitive impairment, then conduct a randomized controlled trial to test an intervention to improve adherence to sleep apnea treatment for improving or preserving cognitive function; 4) Genotype DNA from saliva samples, catalog the frequency of genetic markers for ADRD risk, and calculate polygenic risk scores for ADRD using biospecimens from 2,700+ AI/ANs and NHPIs; and 5) Create an innovative P01 to understand, intervene on, and mitigate ADRD disparities in AI/ANs and NHPIs. Our leadership, resources, and experience offer an unprecedented opportunity to address the National Institute on Aging’s research priorities for underrepresented minorities, as articulated in the National Plan to Address Alzheimer's Disease, and to respond directly to its interest in diversifying the scientific workforce.

总体：摘要 美洲印第安人/阿拉斯加原住民（AI/ANS），夏威夷原住民和太平洋岛民（NHPIS）越来越多 关注阿尔茨海默氏病和相关痴呆症，因为这些疾病很快将产生重大影响 尽管AI/ANS和NHPI具有很高的ADRD风险因素，包括 高血压和2型糖尿病，他们的预期寿命在过去5年中提高了30年 几十年来，其人口在65岁以上的人群中的三倍。不幸的是，医疗保健 为AI/ANS和NHPI服务的系统没有为临床，社会和经济的准备 与Adrd。参与阿尔茨海默氏症研究中心的当地人将是唯一包括AI/ANS或 自国家老化研究所以来，夏威夷人于1984年开始对P01进行分类。位于华盛顿 州立大学，与迈阿密大学，杨百翰大学的合作者和其他几个专业 大学以及AI/AN和NHPI社区合作伙伴，我们将创建一个创新的计划 理解，干预和减轻我们优先人群经历的与ADRD相关的健康分布。 我们的3个研究项目将得到行政，研究方法，招聘和参与的支持， 和生物循环核心。该中心还将设有由本地研究人员领导的8个卫星中心网络 其中包括90％AI/ANS和NHPI居住的区域。这些卫星中心将确保我们的工作 而且我们的传播努力是全国性的，并有助于建立准备就绪的研究队列。中心将 团结社会，临床和行为科学的学者。值得注意的是，12个AI/AN或NH/PI专业人员有 致力于参加调查员或顾问。这是我们的具体目的是：1）在一个小组中 - 随机试验，测试文化知情的提供者培训和“痴呆友好诊所”的有效性 用于检测和适当管理AI/ADD患者和轻度认知患者的干预措施 至少20个为AI/ANS服务的城市和粗糙诊所的损害； 2）在集体随机对照试验中，测试 呼啦式干预对预防NHPI长老认知能力下降的有效性 夏威夷群岛的障碍或轻度认知障碍； 3）在一项观察性研究中，筛选AIS 2远程预订社区，用于阻塞性睡眠呼吸暂停和认知障碍，然后进行一次 随机对照试验测试干预措施以提高对睡眠呼吸暂停治疗的依从性 或保留认知功能； 4）来自唾液样品的基因型DNA，分类遗传的频率 ADRD风险的标记，并使用来自2,700+ AI/ANS的生物测量来计算ADRD的多基因风险评分 和NHPIS； 5）创建创新的P01来理解，干预和减轻ADRD差异 AI/ANS和NHPIS。我们的领导，资源和经验提供了一个空前的机会来解决 国家衰老研究所的研究优先事项是代表性不足的少数群体，如国家 计划解决阿尔茨海默氏病，并直接应对其对科学劳动力多样化的兴趣。