Integrative Neurobiology of Social Processes

社会过程的综合神经生物学

基本信息

批准号：
8502759
负责人：
S MARC BREEDLOVE
金额：
$ 12.17万
依托单位：
MICHIGAN STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-07-01 至 2015-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8502759
关键词：
Neurobiology Process social

项目摘要

See instructions): In the wake of the successes in molecular biology, revealing information packed in the genome, behavioral scientists face the daunting task of integrating molecular events into the context of the whole organism, a challenge intensified by growing awareness that the behavior of one individual is exquisitely sensitive to the behaviors of others. Thus to understand the chain of events by which molecular events affect behavior we must not only place those events in the context of a single individual,but also in the context ofindividuals interacting with one another. Including this social sphere into our understanding will be crucial if we are ever to understand human behavioral disorders, since the most common of these (depression, schizophrenia, drug abuse) are very sensitive to the social environment. We propose interdisciplinary training of investigators to consider behavior from multiple levels of analysis, from molecular and cellular events to behavioral outcomes in a social context. Because social interactions can be tremendously complex, we must select models in both traditional and non-traditional species to take advantage of those specific influences of one individualupon the brain and behavior of another. As examples, we study: social learning of song in zebra finches; maternal stimulation of neonates in rats, mice, and voles; dominance hierarchies in spotted hyenas; social modulation of puberty in rats, Syrian hamsters and Siberian hamsters; as well as mating behaviors in a variety of vertebrates. Most of these models also reflect the influence of hormones upon neural structure and behavior because hormones mediate many social signals, and because hormones affect myriad targets in the body, including the brain, to coordinate social behavior. These hormone-sensitive systems permit us to study molecular events, too: secretion of specific hormones, activation of hormone receptor proteins, hormonal modulation of gene expression in the nervous system, nuclear co-factor proteins regulating hormone responsiveness, environmental contaminants altering reproductive behavior, brain peptides regulating parental behaviors, among others. This integration of information, from molecular to social events and back again, must be accomplished for any satisfying understandingof behavior. We have assembled a unique program to train the next generation of researchers to tackle the challenge of studying the contextual determinants of behavior. RELEVANCE (See instructions): We will train graduate students and postdoctoral fellows in the organismal biology of social processes, which are crucial to human health. By exploring hormonal and genetic influences on social behaviors in humans and other species, we hope to gain a better understanding of disorders such as autism, ADHD, anorexia and schizophrenia, as well as societal issues such as aggression and parental behavior.

请参阅说明）：在分子生物学取得的成功之后，揭示了包装在基因组中的信息科学家面临着将分子事件融入整个生物体的艰巨任务，挑战越来越多地意识到一个人的行为对他人的行为。因此，要了解分子事件影响行为的事件链，我们不仅必须将这些事件放在一个人的背景下，还必须在个人的背景下互相互动。如果我们曾经，将这个社会领域包括在我们的理解中至关重要了解人类行为障碍，因为这些障碍最常见（抑郁症，精神分裂症，药物虐待）对社会环境非常敏感。我们建议对调查人员进行跨学科培训考虑从分子和细胞事件到行为结果的多个分析的行为在社会背景下。因为社交互动可能非常复杂，所以我们必须在两者中选择模型传统和非传统物种，以利用一个单独的upon的特定影响另一个人的大脑和行为。作为示例，我们研究：斑马雀科中歌曲的社会学习；母亲刺激大鼠，小鼠和田鼠的新生儿；发现鬣狗的主导地位；社会调制大鼠，叙利亚仓鼠和西伯利亚仓鼠的青春期；以及各种各样的交配行为脊椎动物。这些模型中的大多数还反映了激素对神经结构和行为的影响因为激素介导了许多社会信号，并且激素会影响体内的无数靶标，所以包括大脑，以协调社会行为。这些激素敏感的系统使我们能够学习也是分子事件：特定激素的分泌，激素受体蛋白的激活，激素在神经系统中调节基因表达，调节激素的核co因子蛋白响应能力，改变生殖行为的环境污染物，调节父母的脑肽行为等。从分子到社交事件再返回的信息整合，必须实现任何令人满意的理解行为。我们已经组装了一个独特的程序培训下一代研究人员，以应对研究的挑战行为。相关性（请参阅说明）：我们将在社会过程的生物学生物学中培训研究生和博士后研究员对于人类健康至关重要。通过探索荷尔蒙和遗传对人类社会行为的影响和其他物种，我们希望对自闭症，多动症，厌食症和精神分裂症以及社会问题，例如侵略和父母行为。