Steroid Hormone Regulation of Anxiety-Related Behaviors

类固醇激素对焦虑相关行为的调节

基本信息

批准号：
8893535
负责人：
S MARC BREEDLOVE
金额：
$ 22.39万
依托单位：
MICHIGAN STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-04-01 至 2017-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8893535
关键词：
Accounting Adrenal Glands Adult Affect Alleles Americas Amygdaloid structure Androgen Receptor Androgens Anti-Anxiety Agents Anxiety Anxiety Disorders Behavior Brain Brain region Brothers Cell Nucleus Cells Complete Androgen-Insensitivity Syndrome Corticosterone Data Diagnosis Drug abuse Estradiol Estrogen Receptors Estrogens Female Gender Goals Gonadal Hormones Gonadal Steroid Hormones Hippocampus (Brain)Hormonal Hormones Human Hypothalamic structure Knock-out Laboratory Rat Laboratory mice Lead Light Mammals Medial Mediating Mental Depression Mental disorders Mus Mutation Nervous system structure Perinatal Pituitary Gland Play Prefrontal Cortex Psyche structure Rat-1 Rattus Receptor Activation Receptor Gene Replacement Therapy Research Resort Risk-Taking Rodent Role Sex Characteristics Site Steroids Stimulus Stress Technology Testosterone Virus Woman anxiety-like behavior anxiety-related behavior expectation hormone regulation hormone sensitivity hypothalamic-pituitary-adrenal axis immunoreactivity knock-down male men new technology novel therapeutic intervention public health relevance receptor relating to nervous system research study response sex steroid hormone stressor

项目摘要

DESCRIPTION (provided by applicant): Among the most prevalent of mental afflictions, anxiety disorders are more commonly diagnosed in women than in men. There is ample evidence that circulating levels of gonadal steroid hormones, including estrogens such as estradiol and androgens such as testosterone, can reduce anxiety in humans and so may play a role in the sex difference in anxiety disorders. Laboratory mice also show a sex difference in anxiety- like behaviors that, as with anxiety in humans, are reduced by circulating testosterone. In mice, it is clear that circulating levels of steroids modulate anxiety-like behaviors. We want t perform exploratory experiments to determine which brain regions are being affected by hormones to reduce anxiety-like behaviors in mice. Preliminary observations suggest that two plausible brain sites for modulating anxiety, the medial prefrontal cortex and the hippocampus, are not the sites responding to testosterone. Other observations implicate the basolateral amygdala as a potential site of hormone action and we would like to conduct experiments to confirm or refute these indications. Understanding how gonadal hormones act on the brain to reduce anxiety in mice may suggest new therapeutic approaches for anxiety disorder in humans.

描述（由适用提供）：在最普遍的精神痛苦中，焦虑症在女性中比男性更常见。有足够的证据表明，循环的性腺类固醇恐怖量，包括雌二醇和雄激素等雌激素，例如睾丸激素，可以减少人类的动画，因此可能在焦虑症的性别差异中起作用。实验室小鼠还显示出类似焦虑症行为的性别差异，与人类的动画一样，通过循环睾丸激素降低了性别。在小鼠中，很明显，类固醇的循环水平调节了类似动画的行为。我们希望T执行探索性实验，以确定哪些大脑区域受激素影响，以减少小鼠的动画样行为。初步观察结果表明，调节动画的两个合理的大脑位点，介质前额叶皮层和海马并不是对睾丸激素做出反应的部位。其他观察结果暗示基底外侧杏仁核是骑马作用的潜在部位，我们想进行实验以确认或反驳这些适应症。了解性腺马如何在大脑中起作用以减少小鼠的焦虑，这可能暗示了人类焦虑症的新治疗方法。