The Manhattan HIV Brain Bank

曼哈顿艾滋病脑库

• 批准号: 8539921
• 负责人: Susan Morgello
• 金额: $ 131.36万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2018-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8539921
• 关键词: AIDS neuropathy; Acquired Immunodeficiency Syndrome; Age; Aging; Autopsy; Behavioral; Brain; Business Rules; Central Nervous System Diseases; Cessation of life; Characteristics; Client; Clinical; Clinical Data; Cognition Disorders; Collection; Communities; Complex; Data; Data Coordinating Center; Databases; Diagnosis; Dictionary; Disease; Enrollment; Epidemic; Equipment and supply inventories; Future; HIV; Individual; Infection; Instruction; Investigation; Laboratories; Life; Liquid substance; Logic; Longitudinal Studies; Manuals; Maps; Medical; Methods; Minority; Modification; Neurocognitive; Neurologic; Neurology; Neuropathogenesis; Neuropsychology; New York City; Nucleic Acids; Observational Study; Organ Donor; Pathogenesis; Pathologic; Pathology; Patients; Peripheral Nervous System Diseases; Phenotype; Plasma; Primary Health Care; Principal Investigator; Process; Protocols documentation; Records; Reporting; Research; Research Design; Research Personnel; Resources; Sampling Errors; Science; Services; Site; Spinal Cord; System; Testing; Therapeutic; Tissues; Viral; Viral Load result; Viremia; Viscera; Woman; Work; antiretroviral therapy; base; brain tissue; cohort; computerized; high risk; literacy; medical schools; meetings; member; mortality; multidisciplinary; nervous system disorder; neuropsychiatry; neuropsychological; prevent; programs; public health relevance; quality assurance; response; tool

DESCRIPTION (provided by applicant): The Manhattan HIV Brain Bank (MHBB), member of the National NeuroAIDS Tissue Consortium (NNTC), has been a resource for the neuroAIDS research community since 1998. It performs neurologic, neuropsychological, psychiatric, general medical, and autopsy pathology assessments on a cohort of predominantly HIV-infected individuals, who agree to be organ donors upon demise, for the purposes of neuroAIDS and AIDS research. As a result of MHBB's observational longitudinal study, its tissue and fluids resources are densely annotated, and support a wide range of investigations into HIV-associated central (CNS) and peripheral nervous system (PNS) disorders. In the next cycle, MHBB will participate with other members of the NNTC to create a cohort optimized for the study of CNS reservoirs, aging, and pathogenesis of HIV-associated cognitive disorders persisting in the face of antiretroviral therapy. Specifically, MHBB will increase its representatin of older individuals, and those with stably suppressed plasma viral loads following variable CD4 nadirs. With this transition, MHBB will maintain important cohort characteristics reflective of the NYC epidemic, including prominent representation of minorities, women, and socio-culturally and medically complex individuals. MHBB will regularly upload clinical and pathologic information into a central consortium database, participate in all the protocol-defining and qualit assurance programs of the NNTC, and distribute its information, tissues, and fluids to investigators through central processes led by the NNTC data coordination center. MHBB will continue to analyze the behavioral and neurologic phenotypes of its cohort, to better understand how neuroAIDS disorders manifest in aging, demographically diverse individuals living through changes in therapeutic eras. Through observational studies, MHBB will better serve neuroAIDS researchers, as careful delineation of phenotype will assure better assignment of resources to research designs. Furthermore, observational study of HIV-associated CNS and PNS disease will allow MHBB to better understand neurobiologically relevant methods for subject characterization, and how to continue modifications of the cohort as the HIV epidemic continues to evolve.

描述（由申请人提供）：国家神经辅助组织组织（NNTC）的成员曼哈顿艾滋病毒脑库（MHBB）自1998年以来一直是神经辅助研究社区的资源。它执行神经系统，神经心理学，精神病学，普通医学，自动病理学，对Predminty of Predominty of Predominty of Predominty of Predominty of Predominty of Predominty of Predominty of Predominty of Predominty hor IV均具有出于神经辅助和艾滋病研究的目的而灭亡。由于MHBB的观察纵向研究，其组织和流体资源被密集注释，并支持对与HIV相关的中枢（CNS）和周围神经系统（PNS）疾病的广泛研究。在下一个周期中，MHBB将与NNTC的其他成员一起参与，以创建一个优化的队列，以研究CNS储层，衰老和与HIV相关的认知障碍的发病机理，面对抗逆转录病毒治疗。具体而言，MHBB将增加其对老年人的代表性，并且在可变CD4 NADIRS之后具有稳定抑制的血浆病毒载荷的人。通过这种过渡，MHBB将保持重要的队列特征反映 纽约市的流行病，包括少数民族，妇女和社会文化和医学复杂的个体的显着代表。 MHBB将定期将临床和病理信息上传到中央联盟数据库中，参与NNTC的所有定义和质量保证计划，并通过NNTC数据协调中心通过中央过程将其信息，组织和流体分发给研究人员。 MHBB将继续分析其队列的行为和神经系统表型，以更好地理解神经辅助障碍如何通过治疗时代的变化生活在衰老的人口统计学多样的个体中。通过观察性研究，MHBB将更好地为神经辅助研究人员提供服务，因为仔细的表型描述将确保更好地分配资源到研究设计。此外，对HIV相关的中枢神经系统和PNS疾病的观察性研究将使MHBB能够更好地理解神经生物学相关的受试者表征方法，以及如何继续随着HIV流行的发展继续修改同伴。