THE MANHATTAN HIV BRAIN BANK

曼哈顿艾滋病毒脑库

• 批准号: 7953654
• 负责人: Susan Morgello
• 金额: $ 5.38万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7953654
• 关键词: AIDS neuropathy; Autopsy; Brain; Clinical Research; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Disease; Dissection; Funding; Grant; HIV; Hepatic; Institution; Investigation; Liquid substance; Liver diseases; Longitudinal Studies; Morbidity - disease rate; National NeuroAids Tissue Consortium; Neurologic; Neurologic Dysfunctions; Neuropsychology; Organ Donations; Pathogenesis; Pathologic; Pathology; Patients; Qualifying; Recruitment Activity; Research; Research Personnel; Resources; Risk; Site; Source; Testing; Tissues; Transplantation; United States National Institutes of Health; cohort; defined contribution; health disparity; human tissue; mortality; programs; AIDS neuropathy; Autopsy; Brain; Clinical Research; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Disease; Dissection; Funding; Grant; HIV; Hepatic; Institution; Investigation; Liquid substance; Liver diseases; Longitudinal Studies; Morbidity - disease rate; National NeuroAids Tissue Consortium; Neurologic; Neurologic Dysfunctions; Neuropsychology; Organ Donations; Pathogenesis; Pathologic; Pathology; Patients; Qualifying; Recruitment Activity; Research; Research Personnel; Resources; Risk; Site; Source; Testing; Tissues; Transplantation; United States National Institutes of Health; cohort; defined contribution; health disparity; human tissue; mortality; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Manhattan HIV Brain Bank (MHBB) is a resource that provides well-characterized human tissues and fluids for NeuroAIDS research. As part of the National NeuroAIDS Tissue Consortium (NNTC), it distributes materials to a wide range of investigators, and has begun a program of observational investigation. In the next 5 year period, we will continue and increase the provision of information, tissues, and fluids from HIV-infected patients to qualified researchers investigating HIV pathogenesis, and continue to recruit HIV-infected patients into an organ donation program preceded by a longitudinal neurologic, neuropsychologic, and psychiatric study. Both individually and with other NNTC sites, we will examine traditional clinico-pathologic correlations of premortem function with postmortem pathology, and to examine the longitudinal progression of neuroAIDS disorders. We will additionally create an organ donation program in an HIV-negative control cohort, that will serve as a source of virologic control materials and also aid in the dissection of hepatic influences on NeuroAIDS disorders. Specifically, a group of pre-transplant liver disease patients with well-defined risk of mortality will be recruited to an organ donation program and longitudinal study with the NNTC battery of tests. There will be a continued focus on co-morbidities and health disparities in HIV-related CNS and PNS disorders, particularly in defining contributions of liver disease, substance disorders, and HIV on cognitive and neurologic dysfunction.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 曼哈顿HIV脑库（MHBB）是一种资源，可为神经辅助研究提供良好的人体组织和流体。 作为国家神经辅助组织（NNTC）的一部分，它将材料分配给广泛的研究人员，并开始了一项观察研究计划。 在接下来的5年期间，我们将继续并增加信息，组织和从HIV感染的患者提供研究HIV发病机理的合格研究人员的提供，并继续将感染的HIV感染的患者招募到纵向神经学，神经心理学和精神病学研究之前。 无论是单独的和其他NNTC站点，我们都将检查前验尸功能与死后病理学的传统临床病理相关性，并检查神经辅助疾病的纵向进展。 我们还将在HIV阴性控制队列中创建一个器官捐赠计划，该计划将作为病毒控制材料的来源，并有助于解剖肝对神经辅助疾病的影响。 具体而言，将招募一组具有明确死亡风险的前移植前肝病患者，并通过NNTC测试量招募了器官捐赠计划和纵向研究。 将继续关注与HIV相关的中枢神经系统和PNS疾病中的合并症和健康差异，特别是在确定肝病，药物疾病以及HIV对认知和神经功能障碍的贡献时。