The Manhattan HIV Brain Bank

曼哈顿艾滋病脑库

• 批准号: 7494194
• 负责人: Susan Morgello
• 金额: $ 162.34万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-05 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7494194
• 关键词: AIDS neuropathy; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; African American; Autopsy; Brain; Collaborations; Collection; Data; Development; Feasibility Studies; Gender; HIV; Hispanics; Immunohistochemistry; Individual; Knowledge; Laboratories; Leadership; Life; Liquid substance; Minority; Morbidity - disease rate; Nervous system structure; Neurocognitive; Participant; Peripheral Nervous System Diseases; Personal Satisfaction; Persons; Population; Research; Research Personnel; Resources; Sampling; Series; Site; Structure; Tissue Microarray; Tissue Sample; Tissues; Woman; base; cohort; computerized data processing; member; nervous system disorder; neurobiological mechanism

DESCRIPTION (provided by applicant): The National NeuroAIDS Tissue Consortium (NNTC) was established in 1998 to advance neuroAIDS research by providing nervous system tissues and fluid samples from persons dying with HIV on whom comprehensive neuromedical, neurocognitive, psychiatric, and laboratory data were gathered during life. The Manhattan HIV Brain Bank (MHBB) is one of 4 founding members of the NNTC. The NNTC has collected antemortem data on 1728 participants and autopsied 721 individuals, distributing samples and data to 212 requests from investigators. While maintaining comprehensive, standardized data and tissue accrual processes and data/sample distribution, the NNTC proposes a restructuring plan to enable development of a consortium-wide scientific agenda. Three levels of scientific activity are envisioned: 1) local preliminary/feasibility studies at NNTC sites, taking advantage of unique expertise; 2) an NNTC-wide "internal" agenda addressing questions with the consortium's large, unique collection of antemortem and postmortem information; and 3) providing broader leadership for new directions in neuroAIDS research. The MHBB will be uniquely poised to contribute to all levels of resource and scientific activity in the new NNTC. Our cohort, with its large percentage of African American and Hispanic minorities, is representative of the US populations disproportionately impacted by HIV/AIDS. Our large percentage of women and collaboration with the Women's Interagency HIV Study offer an opportunity to evaluate gender-related aspects of nervous system disorders. We have begun, and propose to continue, a series of local pilot analyses to elucidate the impact of co-morbidities and neuroAIDS disparities in the MHBB, which we will advance to the shared NNTC agenda. We have assembled investigators whose expertise is well suited to contribute to the development of internal and broader agendas studying disparities, co-morbidities and peripheral neuropathy. We have supported, and will continue to assist, a variety of neuroAIDS and AIDS investigators by providing tissue samples, and will enhance sample value by performing tissue microarray-based immunohistochemistry to uniformly annotate the NNTC brain collection. The new scientific emphasis and revised structure of the NNTC, with full participation of the MHBB, will enable us to contribute, and be responsive, to rapidly evolving knowledge regarding the neurobiological mechanisms underlying AIDS-related nervous system disorders. Part A:

描述（由申请人提供）：1998年成立了国家神经辅助组织（NNTC），以通过为HIV垂死的人提供神经系统组织和流体样本来推动神经辅助研究，并在生命中收集了全面的神经医学，神经认知，精神病学，精神病学和实验室数据。曼哈顿艾滋病毒脑库（MHBB）是NNTC的4个创始成员之一。 NNTC已收集了1728名参与者的反典礼数据，并尸检了721名个人，将样本和数据分配给研究人员的212个请求。 NNTC在维持全面的，标准化的数据和组织应计过程以及数据/样本分布的同时，提出了一个重组计划，以实现整个财团的科学议程的发展。设想了三个级别的科学活动：1）利用独特的专业知识，在NNTC站点进行了本地初步/可行性研究； 2）NNTC范围内的“内部”议程，该议程与财团的大型原质词和验尸信息有关； 3）为神经辅助研究的新方向提供更广泛的领导。 MHBB将被唯一准备为新NNTC的所有资源和科学活动做出贡献。我们的队列占非裔美国人和西班牙裔少数群体的大部分，代表了美国人口受艾滋病毒/艾滋病影响不成比例的。我们的大部分妇女和与妇女跨机构艾滋病毒研究的合作为评估与性别相关的神经系统疾病方面提供了机会。我们已经开始并提议继续进行一系列本地试点分析，以阐明MHBB中的合并症和神经辅助差异的影响，我们将晋升为共享的NNTC议程。我们已经组建了研究人员，他们的专业知识非常适合为研究差异，合并症和周围神经病的内部和更广泛议程的发展做出贡献。我们已经支持并将继续协助各种神经辅助和AIDS研究人员，并通过提供组织样品，并通过执行基于组织微阵列的免疫组织化学来提高样品价值，以均匀地注释NNTC脑收集。 NNTC的新科学重点和修订的结构，随着MHBB的全面参与，将使我们能够做出贡献和响应，以迅速发展有关与艾滋病相关的神经系统疾病的神经生物学机制的知识。 A部分：