Miniature Foveated Endoscope for Early Cancer Diagnostics

用于早期癌症诊断的微型中央凹内窥镜

• 批准号: 8549922
• 负责人: TOMASZ S TKACZYK
• 金额: $ 22.92万
• 依托单位: RICE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-30 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8549922
• 关键词: Achievement; Adopted; Architecture; Area; Caliber; Cancer Diagnostics; Cellular Morphology; Clinical; Complement; Confocal Microscopy; Data; Detection; Development; Devices; Diagnostic; Diagnostic Neoplasm Staging; Diamond; Endoscopes; Endoscopy; Engineering; Eye; Feedback; Fluorescence; Foundations; Gastroenterologist; Goals; Human; Image; Imagery; Imaging Device; Imaging technology; Injection of therapeutic agent; Malignant Neoplasms; Methods; Microscope; Microscopy; Molds; Motivation; Optics; Pathologist; Patients; Performance; Peripheral; Principal Investigator; Printing; Publishing; Research Project Grants; Resolution; Resources; Risk; Role; Scanning; Screening for cancer; Specimen; Surface; Surgical Oncologist; System; Technology; Tissues; Translating; Validation; Visible Radiation; Work; base; clinically relevant; cost; design; experience; imaging modality; in vivo; innovation; instrument; interest; miniaturize; novel; optical imaging; prototype; time orientation; tissue phantom; Achievement; Adopted; Architecture; Area; Caliber; Cancer Diagnostics; Cellular Morphology; Clinical; Complement; Confocal Microscopy; Data; Detection; Development; Devices; Diagnostic; Diagnostic Neoplasm Staging; Diamond; Endoscopes; Endoscopy; Engineering; Eye; Feedback; Fluorescence; Foundations; Gastroenterologist; Goals; Human; Image; Imagery; Imaging Device; Imaging technology; Injection of therapeutic agent; Malignant Neoplasms; Methods; Microscope; Microscopy; Molds; Motivation; Optics; Pathologist; Patients; Performance; Peripheral; Principal Investigator; Printing; Publishing; Research Project Grants; Resolution; Resources; Risk; Role; Scanning; Screening for cancer; Specimen; Surface; Surgical Oncologist; System; Technology; Tissues; Translating; Validation; Visible Radiation; Work; base; clinically relevant; cost; design; experience; imaging modality; in vivo; innovation; instrument; interest; miniaturize; novel; optical imaging; prototype; time orientation; tissue phantom

DESCRIPTION (provided by applicant): The goal of this project is to demonstrate the feasibility of a novel endoscopic imaging method based on foveated imaging with additional capabilities for optical sectioning in the central portion of the field of view (FOV). This will alow practical implementation of endo-microscopy in the clinical arena, greatly augmenting diagnostic capabilities for early cancer detection. The device proposed here combines capabilities of a standard endoscope objective and endo- microscope. The objective will image a 5 mm diameter FOV with resolution spanning from 1.5 micron in the center of the field decreasing to 25 microns at the peripheral edges of the field. The resolution within the 5 mm FOV will be changing continuously, in a similar way to that achieved by the human eye (where the best resolution is in the center and degrades on periphery). In result a high resolution will be obtained in the central 500 micron field area. In addition optical sectioning capabilities using fluorescence confocal microscopy will be available at the center of the FOV. Therefore the proposed optical system is envisioned to enable a seamless transition from the wide-field imaging configuration to the confocal imaging configuration in a wide variety of endoscopic imaging applications. Importantly, the lower resolution image of the tissue surface will be available at all times for orientation and identification of regions of interest. The project consists of two specific aims. They focus on (1) development of the optical-design, fabrication and assembly of the foveated miniature optical systems and (2) objective validation for phantom and tissue imaging to obtain clinician feedback.

描述（由申请人提供）：该项目的目的是证明基于Foveated Imaging的新型内窥镜成像方法的可行性，并在视野中央部分（FOV）中具有其他功能，可用于光学分段（FOV）。这将在临床领域实施实际实施，从而大大增加了早期癌症检测的诊断能力。这里提出的设备结合了标准内窥镜物镜和内部显微镜的功能。该目标将成像一个直径为5 mm的FOV，分辨率从田间中心的1.5微米跨度下降到该场外围边缘处的25微米。 5 mM FOV内的分辨率将以与人眼相似的方式（最佳分辨率在中心位于中心并在外围降解）类似的方式变化。因此，将在中央500微米田地区域获得高分辨率。另外，使用荧光共聚焦显微镜的光学切片功能将在FOV的中心提供。因此，设想提出的光学系统可以实现从宽场成像配置到各种内窥镜成像应用中的共聚焦成像配置的无缝过渡。重要的是，组织表面的较低分辨率图像始终可用于方向和 识别利益区域。该项目由两个具体目标组成。他们专注于（1） 开发FOVEAT的微型光学系统的光学设计，制造和组装以及（2）对幻影和组织成像的客观验证，以获得临床医生的反馈。