Miniature Foveated Endoscope for Early Cancer Diagnostics

用于早期癌症诊断的微型中央凹内窥镜

基本信息

批准号：
8549922
负责人：
TOMASZ S TKACZYK
金额：
$ 22.92万
依托单位：
RICE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-30 至 2015-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8549922
关键词：
Achievement Adopted Architecture Area Caliber Cancer Diagnostics Cellular Morphology Clinical Complement Confocal Microscopy Data Detection Development Devices Diagnostic Diagnostic Neoplasm Staging Diamond Endoscopes Endoscopy Engineering Eye Feedback Fluorescence Foundations Gastroenterologist Goals Human Image Imagery Imaging Device Imaging technology Injection of therapeutic agent Malignant Neoplasms Methods Microscope Microscopy Molds Motivation Optics Pathologist Patients Performance Peripheral Principal Investigator Printing Publishing Research Project Grants Resolution Resources Risk Role Scanning Screening for cancer Specimen Surface Surgical Oncologist System Technology Tissues Translating Validation Visible Radiation Work base clinically relevant cost design experience imaging modality in vivo innovation instrument interest miniaturize novel optical imaging prototype time orientation tissue phantom

项目摘要

DESCRIPTION (provided by applicant): The goal of this project is to demonstrate the feasibility of a novel endoscopic imaging method based on foveated imaging with additional capabilities for optical sectioning in the central portion of the field of view (FOV). This will alow practical implementation of endo-microscopy in the clinical arena, greatly augmenting diagnostic capabilities for early cancer detection. The device proposed here combines capabilities of a standard endoscope objective and endo- microscope. The objective will image a 5 mm diameter FOV with resolution spanning from 1.5 micron in the center of the field decreasing to 25 microns at the peripheral edges of the field. The resolution within the 5 mm FOV will be changing continuously, in a similar way to that achieved by the human eye (where the best resolution is in the center and degrades on periphery). In result a high resolution will be obtained in the central 500 micron field area. In addition optical sectioning capabilities using fluorescence confocal microscopy will be available at the center of the FOV. Therefore the proposed optical system is envisioned to enable a seamless transition from the wide-field imaging configuration to the confocal imaging configuration in a wide variety of endoscopic imaging applications. Importantly, the lower resolution image of the tissue surface will be available at all times for orientation and identification of regions of interest. The project consists of two specific aims. They focus on (1) development of the optical-design, fabrication and assembly of the foveated miniature optical systems and (2) objective validation for phantom and tissue imaging to obtain clinician feedback.

描述（由申请人提供）：该项目的目标是证明基于中心凹成像的新型内窥镜成像方法的可行性，该方法具有在视场（FOV）中心部分进行光学切片的附加功能。这将使内窥镜检查在临床领域得到实际应用，大大增强早期癌症检测的诊断能力。这里提出的设备结合了标准内窥镜物镜和内窥镜的功能。该物镜将对直径 5 毫米的视场进行成像，分辨率范围从视场中心的 1.5 微米降低到视场外围边缘的 25 微米。 5 毫米视场内的分辨率将不断变化，类似于人眼所达到的分辨率（最佳分辨率在中心，在外围降低）。结果，在中心 500 微米视场区域将获得高分辨率。此外，FOV 中心将提供使用荧光共焦显微镜的光学切片功能。因此，设想所提出的光学系统能够在各种内窥镜成像应用中实现从宽视场成像配置到共焦成像配置的无缝过渡。重要的是，组织表面的较低分辨率图像将始终可用于定向和识别感兴趣的区域。该项目有两个具体目标。他们专注于（1）开发中心凹微型光学系统的光学设计、制造和组装，以及 (2) 对体模和组织成像进行客观验证以获得临床医生的反馈。