Administrative Core

行政核心

• 批准号: 10294398
• 负责人: Karel Svoboda
• 金额: $ 32.46万
• 依托单位: ALLEN INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-01-15 至 2026-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10294398
• 关键词: Achievement; Adherence; Adopted; Adoption; Anatomy; Architecture; Area; Authorship; Behavior; Behavioral; Budgets; Collaborations; Communication; Communities; Computer software; Data; Data Analyses; Data Science Core; Data Set; Electrophysiology (science); Ensure; Feedback; Fostering; Generations; Goals; Image; Individual; Industry; Infrastructure; Institutes; Institution; Joints; Leadership; Logic; Manuscripts; Maps; Modernization; Molecular; Monitor; Neurosciences; New York; Performance; Phase; Procedures; Process; Production; Progress Reports; Publications; Quality Control; Reporting; Research; Research Personnel; Research Project Grants; Resources; Risk Management; Role; Route; Science; Shapes; Signal Transduction; Site; Software Tools; Standardization; Strategic Planning; Structure; Synapses; Thalamic structure; Time; Universities; base; cell type; cloud based; cohesion; computational network modeling; computerized data processing; conflict resolution; data exchange; data integration; data quality; data resource; data sharing; data standards; density; design; experience; frontal lobe; member; multimodal data; neural circuit; neurophysiology; optogenetics; organizational structure; programs; relating to nervous system; repository; software development; theories; tool

Summary, Administrative Core The proposal “Thalamus in the middle: computations in multi-regional neural circuits” aims to combine expertise in theory, molecular neuroscience, modern high-throughput anatomy, cellular and synaptic neurophysiology, and large-scale neurophysiology in the context of quantitative behavior. The overall project consists of five Projects, focusing on how information flows from subcortical areas, through thalamus, to control cortical activity modes and thereby shape behavior; a Molecular Science Core, a Data Science Core, and an Administrative Core with 5 PIs and two collaborative sites. Realizing the potential of this project requires strong administrative leadership to integrate and synergize efforts across the collaborating researchers at New York University and the Allen Institute. The Administrative Core will provide the structure, leadership and operational management of the overall project to advance the goal of understanding neural computation in subcortex → thalamus → cortex circuits. This will include project management, strategic planning, progress reporting, fiscal management, and support for collaboration and communication. The Administrative Core will create an infrastructure that fosters communication and collaboration among the members, as well as garnering input from the external research community through the formation of an External Scientific Advisory Board. The overall project will form a Steering Committee and Project Teams to oversee the collaborative, standardized, and on-time data generation, data analysis, and public data sharing process. Project management best practices, such as milestones, progress reporting and tracking, collaborative software programs, and a responsibility matrix will be applied to ensure achievement of performance objectives and milestones, optimized communication, and resource utilization and prioritization. In addition, the Administrative Core will foster joint data analysis efforts across projects and Institutions. To produce a high-quality tools and data resource, rigorous standardization and quality control practices will be adopted by all members. Finally, the Administrative Core will implement and maintain fiscal and subcontractor management processes for all members, manage publication and authorship decisions and conflict resolution. With the implementation of this entire infrastructure, we anticipate that this project and the resources it produces will have a broad and meaningful impact on uncovering the logic of signal routing from subcortical areas to the frontal cortex thalamus.

摘要，行政核心 提案“中间的丘脑：多区域神经回路中的计算”旨在结合专业知识 从理论上讲，分子神经科学，现代高通量解剖学，细胞和突触神经生理学以及 在定量行为的背景下，大规模的神经生理学。整个项目由五个项目组成， 关注信息从皮层下区域，通过丘脑如何流动以控制皮层活动模式 从而形成行为；分子科学核心，数据科学核心和行政核心 5个PI和两个协作网站。意识到该项目的潜力需要强大的行政领导 在纽约大学和艾伦的合作研究人员中整合和协同努力 研究所。 行政核心将提供整个项目的结构，领导和运营管理 为了促进理解亚皮质中中性计算的目标→丘脑→皮层电路。这会 包括项目管理，战略规划，进度报告，财政管理以及对 协作与沟通。管理核心将创建一个基础架构，以促进 成员之间的沟通和协作，并从外部研究中获得意见 通过成立外部科学顾问委员会的社区。整个项目将形成转向 委员会和项目团队以监督合作，标准化和准时数据的数据，数据 分析和公共数据共享过程。项目管理最佳实践，例如里程碑，进度 将应用报告和跟踪，协作软件程序和责任矩阵以确保 实现绩效目标和里程碑，优化的沟通以及资源利用率以及 优先级。此外，行政核心将促进跨项目的联合数据分析工作， 机构。为了产生高质量的工具和数据资源，严格的标准化和质量控制 所有成员将采用实践。最后，行政核心将实施并维护财政 所有成员的分包商管理流程，管理出版物和作者身份决策以及 解决冲突。随着整个基础架构的实施，我们预计该项目和 它产生的资源将对从中发现信号路由的逻辑产生广泛而有意义的影响 额叶皮层丘脑的皮质下区域。