Imaging CAncer Screening Patch (CASP) for early diagnostics of cervical cancers

用于宫颈癌早期诊断的成像癌筛查贴片 (CASP)

基本信息

批准号：
9316232
负责人：
TOMASZ S TKACZYK
金额：
$ 17.44万
依托单位：
RICE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-03-01 至 2019-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9316232
关键词：
Address Age Algorithms Area Biopsy Caliber Cancer Detection Cervical Cervical Cancer Screening Cervical dysplasia Cervix Uteri Clinical Cancer Center Clinical Research Collaborations Colposcopy Country Cytology Development Devices Diagnosis Diagnostic Dysplasia Educational Status Endoscopes Feasibility Studies Foundations Future Generations Goals Health care facility Human Papilloma Virus Vaccination Human Papillomavirus Human Resources Human papilloma virus infection Image Image Analysis Imaging Device Incidence Income Individual Infection Loop electrosurgical excision procedure Malignant Neoplasms Malignant neoplasm of cervix uteri Maps Medically Underserved Area Microinvasive Monitor Nuclear Optics Output Pap smear Pathology Patients Performance Pilot Projects Preventive vaccine Procedures Protocols documentation Recording of previous events Research Research Infrastructure Resolution Resources Rice Rotation Sampling Screening for cancer Screening procedure Secondary Prevention Series Shapes Solid Specimen Surface System Testing Time Tissue Model Tissue imaging Tissues Training Translating Vaccines Visit Woman Work boys cancer imaging cellular imaging cost data acquisition design experience flexibility follow-up girls high risk image processing imaging system insight instrument low and middle-income countries mortality novel diagnostics point-of-care diagnostics programs prototype response screening tool uptake

项目摘要

Imaging CAncer Screening Patch (CASP) for early diagnostics of cervical cancers The work pursued within this proposal will carry out the feasibility studies to develop a new class of high resolution, non-invasive, optical multi-field of view, flexible surface imaging devices for cervical cancer detection and screening. The device is a response for an unmet crucial need of a lack of point-of-care diagnostic tools for cervical dysplasia and cancer in patients with an abnormal screening Pap and/or HPV test. The proposed tool called Cancer Screening Patch or CASP will be capable of providing pathology level resolution over large areas of tissue and therefore can become an effective diagnostic instrument. To simplify the screening procedure the system will be merged with image analysis tools to provide objective parameters like nuclear to cytoplasmic ratio (NCR) and allow screening by low/medium training level personnel. The initial results will be available within minutes, allowing for a “Screen & Treat” approach and eliminating the need for pathology review and associated wait times and additional return visits. The core idea of the approach is combining high resolution micro-endoscopes into multi-point flexible imaging patch array conforming to the shape of cervix and providing high sampling map available for numerical analysis. Specifically we will develop prototypes of CASP capable of sub-cellular imaging resolution over large tissue areas with image sampling of 2-4 microns at 100-150 FOVs. The target individual probing areas will have diameter of 200-450 microns and will be densely populated over imaged tissue and converged into a single camera output. In parallel we will develop effective analysis tools to provide objective assessment parameters like nuclear to cytoplasmic ratio, NCR thresholding and border delineation. To further increase imaged area and resolution, the probe can be linearly or rotationally shifted and imaged zones will be merged with mosaicking algorithms. Finally we will evaluate system imaging performance using both tissue models as well as ex-vivo LEEP specimens from 20 patients with a high- grade dysplasia in a pilot clinical study.

用于早期诊断宫颈癌的成像癌症筛查贴片 (CASP) 本提案所开展的工作将进行可行性研究，以开发一种新的高分辨率、非侵入式、光学多视场、柔性表面成像用于宫颈癌检测和筛查的设备该设备是对未满足的问题的回应。迫切需要缺乏宫颈发育不良和癌症的现场诊断工具巴氏涂片检查和/或 HPV 检测异常的患者所提出的工具称为癌症。筛选贴片或 CASP 将能够提供大范围的病理级别分辨率因此可以成为有效的诊断工具。筛选程序该系统将与图像分析工具合并，以提供客观的核质比 (NCR) 等参数，并允许低/中筛选培训级别的人员将在几分钟内获得初步结果，以便进行培训。 “筛查和治疗”方法，消除了病理检查和相关等待的需要该方法的核心思想是结合高分辨率。将微型内窥镜组装成符合形状的多点柔性成像贴片阵列子宫颈并提供可用于数值分析的高采样图。具体来说，我们将开发能够实现亚细胞成像分辨率的 CASP 原型在 100-150 FOV 下对大组织区域进行 2-4 微米的图像采样。单个探测区域的直径为 200-450 微米，并且人口密集我们将同时开发成像组织并汇聚成单个相机输出。有效的分析工具，提供客观的评估参数，如核细胞质比率、NCR 阈值和边界描绘以进一步增加成像区域。和分辨率，探头可以线性或旋转移动，成像区域将最后我们将与镶嵌算法相结合来评估系统成像性能。使用组织模型以及来自 20 名高水平患者的离体 LEEP 标本初步临床研究中的级别不典型增生。