Senior Research Career Scientist

高级研究职业科学家

基本信息

批准号：
10672971
负责人：
RONALD J TRIOLO
金额：
--
依托单位：
LOUIS STOKES CLEVELAND VA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-10-01 至 2028-09-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10672971
关键词：
Achievement Acute Address Adopted Affect American Amputation Amputees Animals Ankle Architecture Archives Area Award Biomechanics Biomedical Engineering Book Chapters Central Nervous System Chronic Chronic Disease Clinical Collaborations Communities Community Participation Contracts Dedications Development Devices Diabetes Mellitus Disabled Persons Education Electrodes Employee Environment Equilibrium Esthesia Etiology Exercise Exhibits Fall prevention Fatigue Femur Floor Funding Gait Gait abnormality Health Healthcare Heart Hospital Costs Human Immobilization Impairment Implant Individual Injury Intervention Intuition Joints Journals Knee Laboratory Study Legal patent Leisure Activities Life Style Limb Prosthesis Limb structure Location Lower Extremity Lung Malignant Neoplasms Manual wheelchair Manuals Manufacturer Mechanics Mechanoreceptors Mediation Medical Medical Device Medical Students Medical center Medicine Mentors Methods Modality Motion Motor Movement Multi-Institutional Clinical Trial Multiple Sclerosis Muscle Muscle Contraction Musculoskeletal Equilibrium Names Nerve Neuromechanics Neuromuscular Diseases Neurons Operative Surgical Procedures Output Paper Paralysed Participant Peer Review Pelvis Perception Performance Peripheral Peripheral Nerves Personal Satisfaction Phase Physical Medicine Physical Rehabilitation Population Postdoctoral Fellow Posture Preclinical Testing Principal Investigator Process Productivity Psychophysics Publications Ramp Reaction Recurrence Rehabilitation therapy Reporting Research Research Personnel Risk Safety Scientist Self-Help Devices Seminal Sensory Series Services Site Skin Social isolation Spinal Cord Spinal cord injury Stroke System Technology Textbooks Tissues Translations Trauma United States Department of Veterans Affairs United States National Institutes of Health Universities Vertebral column Veterans Veterans Health Administration Visual Walking Wheelchair propulsion Wheelchairs Work body system bone career clinical application clinical translation computerized tools cost design diabetic disability erection exercise intervention exoskeleton experience fall injury falls feasibility trial first-in-human foot functional independence graduate student improved innovation limb loss neural neural implant neural prosthesis neural stimulation neuroprosthesis novel prevent programs rehabilitation research research and development residual limb sciatic nerve sedentary lifestyle senior faculty social spine bone structure surgery outcome technology platform technology/technique translational framework unhealthy lifestyle walking speed

项目摘要

Dr. Ronald J. Triolo is Senior Research Career Scientist with the Rehabilitation R&D Service, and a Tenured Full Professor of Biomedical Engineering at Case Western Reserve University. He is Executive Director of the VA RR&D Center for Advanced Platform Technology which develops novel medical devices and assistive restorative technologies for individuals with sensorimotor impairments or limb loss. Dr. Triolo has authored over 150 peer-reviewed publications and textbook chapters, and has mentored more than 40 graduate and medical students or post-doctoral trainees. He currently leads independent research programs funded the VA, NIH, DoD and other agencies as Principal or Co-Principal Investigator. Dr. Triolo was inducted into the American Institute for Medical and Biological Engineering, received the Paul B. Magnuson Award for outstanding achievement in Rehabilitation Research and Development from the VA, and was named the Outstanding Veterans Health Administration Employee (Honorable Mention) of 2020 by the Disabled American Veterans (DAV). Dr. Triolo has devised, patented and evaluated assistive devices to facilitate the sit-to-stand transition and negotiate stairs, ramps or other architectural barriers, and is in the process of preparing novel interventions for exercising after spinal cord injury (SCI) for dissemination within the VHA. His research program encompasses five main areas: 1. Implanted Neuroprostheses for Standing and Walking: Dr. Triolo leads an interdisciplinary team dedicated to developing, deploying, and evaluating the clinical outcomes of surgically implanted motor system neuroprostheses for lower extremity function after SCI. He quantifies their acute and chronic performances, and explores novel methods of integrating stimulated and volitional muscle activity. His team creates new computational tools to analyze the biomechanics of bipedal stance and stepping, and applies them to optimize control systems for maintaining erect balance or facilitating efficient walking. 2. Seated Balance and Wheelchair Propulsion: This research explores methods to control the paralyzed pelvis and spine to restore vertebral alignment, extend bimanual reach, provide active sitting balance, and enhance mechanical efficiency of manual wheelchair propulsion. Dr. Triolo documents the effects of modulating stiffness of the trunk on regulating upright posture to prevent falls from the wheelchair and expand control over objects in the environment. 3. Selective Peripheral Nerve Interfaces: Dr. Triolo has designed and verified the safety and performance of new, highly selective multicontact peripheral nerve electrodes capable of isolating functionally distinct fascicular groups within a common nerve trunk. Selectivly activating of independent groups of neurons can elicit multiple joint motions, or discrete sensations perceived as arising from the missing limb, from a common surgical site on the proximal nerve, and alternating between synergistic motor unit pools can prolong force output and delay onset of fatigue. 4. Natural Sensation for Lower Limb Amputees: This program applies selective multicontact nerve electrodes to activate the sensory components of the sciatic nerve above the knee in the residual limbs of amputees to induce sensations referred to the missing limb. Elicited sensory information is processed by the CNS in a manner similar to input from intact mechanoreceptors, and can improve standing and ambulatory ability after traumatic or diabetic limb loss, and is being integrating with motorized lower limb prostheses. 5. Neuromechanical Gait Assist Systems: Dr. Triolo develops novel exoskeletal systems to facilitate bipedal mobility for individuals with SCI or other neuromuscular disorders. His innovative “muscle first” approach integrates mechanical components with volitional or electrically activated muscle contractions to maximize physical benefit and achieve the walking speeds required for community ambulation.

Ronald J. Triolo博士是康复研发服务的高级研究职业科学家，终身 Case Western Reserve University的生物医学工程教授完整。他是执行董事 VA RR＆D高级平台技术中心，该中心开发了新颖的医疗设备和有感觉运动障碍或肢体损失的个体的辅助修复技术。 Triolo博士有撰写了150多个同行评审的出版物和教科书章节，并负责40多个研究生和医学生或博士后学员。他目前领导独立研究计划资助了VA，NIH，DOD和其他机构，担任主要或联合主管调查员。 Triolo博士入选进入美国医学与生物工程研究所，获得了Paul B. Magnuson 弗吉尼亚州的康复研究和发展卓越成就奖，是被任命残疾美国退伍军人（DAV）。 Triolo博士已设计，专利和评估了辅助设备促进坐姿到立式的过渡，并谈判楼梯，坡道或其他建筑障碍，并在在脊髓损伤（SCI）（SCI）中准备新的干预措施以进行运动的过程 vha。他的研究计划包括五个主要领域： 1。暗示着站立和步行的神经假体：Triolo博士领导一个跨学科团队致力于开发，部署和评估手术植入运动系统的临床结果 SCI后下肢功能的神经假体。他量化了他们的急性和长期表演，并探讨了整合刺激和自愿性肌肉活性的新方法。他的团队创造了新的计算工具来分析两体姿势和步进的生物力学，并将其应用于优化控制直立平衡或支持高效步行的控制系统。 2。座位的平衡和轮椅推进：本研究探讨了控制瘫痪的方法骨盆和脊柱，以恢复椎骨对准，扩展双层触及范围，提供主动的坐余平衡，并提高手动轮椅推进的机械效率。 Triolo博士记录了调节行李箱的刚度在调节直立的姿势上，以防止轮椅从轮椅上掉下来控制环境中的对象。 3。选择性周围神经界面：Triolo博士设计和验证了安全性和性能能够在功能上隔离的新的，高度选择性的多核能外周神经电极普通神经躯干内的束缚组。选择性激活独立的神经元组可以引起多个关节动作或因缺失的肢体而被认为是由常见的肢体引起的离散感觉近端神经上的手术部位，协同运动单元池之间的替代性可以延长力量疲劳的输出和延迟发作。 4。下肢截肢者的自然感觉：此程序应用选择性多接触NEVE 电极在残留的四肢中激活膝盖上方的坐骨神经的感觉成分截肢者引起的感觉是指缺失的肢体。引起的感官信息由中枢神经系统以类似于完整机制感受器的输入的方式，并且可以改善站立和卧床创伤或糖尿病肢体损失后的能力，并与电动下肢假体融为一体。 5。神经力学步态辅助系统：Triolo博士开发了新颖的外骨骼系统以促进对患有SCI或其他神经肌肉疾病的个体的双足动动物。他创新的“肌肉” 方法将机械组件与自愿或电活的肌肉收缩整合到最大程度地利用身体上的好处，并实现社区移动所需的步行速度。