2013 Three-Dimensional Electron Microscopy Gordon Research Conference

2013三维电子显微镜戈登研究会议

• 批准号: 8510255
• 负责人: EDWARD H. EGELMAN
• 金额: $ 0.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-06 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8510255
• 关键词: Algorithms; Amyloid Fibrils; Automobile Driving; Biological; Biomedical Research; Cells; Cellular biology; Classification; Communities; Complex; Computer software; Crystallography; Disease; Electron Microscopy; Event; Financial Support; Funding; Health; International; Macromolecular Complexes; Membrane Proteins; Minority; Molecular; Muscle Fibers; New Hampshire; Organelles; Participant; Phase; Proteins; Request for Proposals; Research; Ribosomes; Scientist; Series; Structure; Techniques; Virus; Woman; biological research; detector; image processing; insight; light microscopy; macromolecular assembly; macromolecule; meetings; multicatalytic endopeptidase complex; pathogen; public health relevance; reconstruction; symposium; tool

DESCRIPTION (provided by applicant): This proposal requests partial funding to support the 2013 Gordon Research Conference on Three- Dimensional Electron Microscopy of Macromolecules (3DEM), continuing this most successful series. Three- dimensional electron microscopy (3DEM) offers unique insights into the structure and mechanisms of biological macromolecules and their assemblies in health and disease. Unlike any other technique in structural and molecular cell biology, 3DEM spans an extraordinarily wide range, from near-atomic detail of membrane proteins and important pathogens such as viruses and amyloid fibrils, to cell organelles such as the ribosome and proteosome, and to whole cells. Most protein in the cell is assembled into complexes, and EM is one of the most important tools for studying macromolecular complexes. It provides a great deal of complementarity with techniques such as x-ray crystallography and NMR, on the one hand, and light microscopy, on the other. Continual advances have been made in this field, from hardware (such as better detectors) to software (such as new algorithms for processing images), and these advances are the main focus for this conference. The impact of the preceding 18 meetings has been such that the 3DEM community has come to regard this Gordon Conference as the most important scientific event in the field. The next 3DEM GRC will be held in New Hampshire in June 2013.

描述（由申请人提供）：该提案要求部分资金支持2013年戈登研究会议大分子的三维电子显微镜（3DEM），继续这一最成功的系列。三维电子显微镜（3DEM）对生物大分子的结构和机制及其在健康和疾病中的组装提供了独特的见解。与结构和分子细胞生物学中的任何其他技术不同，3DEM跨越了一个非常广泛的范围，从膜蛋白的近原子细节以及重要的病原体（例如病毒和淀粉样蛋白原纤维）到核糖体和蛋白质体等细胞细胞器，再到整个细胞。细胞中的大多数蛋白质都组装成复合物，EM是研究大分子复合物的最重要工具之一。它提供了与X射线晶体学和NMR等技术的相互互补性，另一方面是光学显微镜。从硬件（例如更好的探测器）到软件（例如用于处理图像的新算法），在该领域已经取得了持续的进步，这些进步是本次会议的主要重点。前18次会议的影响是，3DEM社区已将这次戈登会议视为该领域最重要的科学事件。下一个3DEM GRC将于2013年6月在新罕布什尔州举行。