Fundamental Mechanobiology of Tumor Progression

肿瘤进展的基础力学生物学

• 批准号: 8545924
• 负责人: Jan T. Liphardt
• 金额: $ 8.38万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-29 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8545924
• 关键词: Area; Behavior; Biological Sciences; Cancer Biology; Cancer Control; Chemistry; Clinical Investigator; Development; Engineering; Environment; Goals; Institution; Knowledge; Laws; Malignant Neoplasms; Mathematics; Measurement; Physical Chemistry; Physics; Process; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Shapes; Testing; anticancer research; base; cancer therapy; innovation; interest; novel; physical science; programs; tumor progression

The goal of the PS-OC initiative is to collectively advance our understanding of the physical laws and principles that shape and govern the emergence of cancer and its behavior at ail scales. The PS-OCs will bring together expert teams from the fields of physics, cancer biology, physical chemistry, mathematics, and engineering to assemble and develop the infrastructure, capabilities, research programs, and the Network required to enable team research converging. the physical sciences with cancer biology. PS-OCs, individually and together, will support and nurture a new trans-disciplinary environment and research that: (1) originates and tests novel, non-traditional physical-sciences based approaches to understanding and controlling cancer; (2) generates orthogonal sets of physical measurements and integrates them with existing knowledge of cancer; and (3) develops and evaluates theoretical physics approaches to provide a comprehensive and dynamic picture of cancer. Ultimately, through coordinated, alternative, trans-Network development and testing of innovative, perhaps non-traditional, approaches to cancer processes, PS-OCs will catalyze and generate new bodies of knowledge and fields of cancer study that identify and define the critical aspects "physics, chemistry, and engineering" that operate at all levels in cancer processes. We are bringing together a cross section of investigators from the Physical and Life Sciences to participate in the center. This includes five Bay Area organizations with globally recognized and long-standing capabilities and interests in the physical sciences, engineering, and cancer research and treatment. We have also recruited clinical investigators from 2 outside institutions to compliment existing expertise and to extend the translational scope of our projects.

PS-OC 计划的目标是共同增进我们对物理定律和原理的理解，这些定律和原理塑造和控制着癌症的出现及其在各种尺度上的行为。 PS-OC 将汇集来自物理学、癌症生物学、物理化学、数学和工程学领域的专家团队，以组装和开发实现团队研究融合所需的基础设施、能力、研究项目和网络。物理科学与癌症生物学。 PS-OC 将单独或共同支持和培育新的跨学科环境和研究，这些环境和研究：(1) 发起和测试新颖的、非传统的基于物理科学的方法来理解和控制癌症； (2) 生成正交的物理测量集并将其与现有的癌症知识相结合； (3) 开发和评估理论物理方法，以提供全面、动态的癌症图景。最终，通过协调的、替代的、跨网络的开发和测试创新的、也许是非传统的癌症过程方法，PS-OC 将催化和产生新的知识体系和癌症研究领域，以识别和定义关键方面”物理学、化学和工程学”在癌症过程的各个层面发挥作用。我们正在汇集来自物理和生命科学领域的跨领域研究人员来参与该中心。其中包括五个在物理科学、工程以及癌症研究和治疗领域具有全球公认的长期能力和兴趣的湾区组织。我们还从 2 个外部机构招募了临床研究人员，以补充现有的专业知识并扩大我们项目的转化范围。