Fundamental Mechanobiology of Tumor Progression

肿瘤进展的基础力学生物学

• 批准号: 8535631
• 负责人: Jan T. Liphardt
• 金额: $ 291.55万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-29 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8535631
• 关键词: Area; Behavior; Biological Sciences; Cancer Biology; Cancer Control; Chemistry; Clinical Investigator; Development; Engineering; Environment; Goals; Institution; Knowledge; Laws; Malignant Neoplasms; Mathematics; Measurement; Physical Chemistry; Physics; Process; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Shapes; Testing; anticancer research; base; cancer therapy; innovation; interest; novel; physical science; programs; tumor progression

The goal of the PS-OC initiative is to collectively advance our understanding of the physical laws and principles that shape and govern the emergence of cancer and its behavior at ail scales. The PS-OCs will bring together expert teams from the fields of physics, cancer biology, physical chemistry, mathematics, and engineering to assemble and develop the infrastructure, capabilities, research programs, and the Network required to enable team research converging. the physical sciences with cancer biology. PS-OCs, individually and together, will support and nurture a new trans-disciplinary environment and research that: (1) originates and tests novel, non-traditional physical-sciences based approaches to understanding and controlling cancer; (2) generates orthogonal sets of physical measurements and integrates them with existing knowledge of cancer; and (3) develops and evaluates theoretical physics approaches to provide a comprehensive and dynamic picture of cancer. Ultimately, through coordinated, alternative, trans-Network development and testing of innovative, perhaps non-traditional, approaches to cancer processes, PS-OCs will catalyze and generate new bodies of knowledge and fields of cancer study that identify and define the critical aspects "physics, chemistry, and engineering" that operate at all levels in cancer processes. We are bringing together a cross section of investigators from the Physical and Life Sciences to participate in the center. This includes five Bay Area organizations with globally recognized and long-standing capabilities and interests in the physical sciences, engineering, and cancer research and treatment. We have also recruited clinical investigators from 2 outside institutions to compliment existing expertise and to extend the translational scope of our projects.

PS-OC计划的目的是共同提高我们对在AIL量表上塑造和控制癌症及其行为的物理定律和原则的理解。 PS-OCS将聚集来自物理，癌症生物学，物理化学，数学和工程领域的专家团队，以组装和开发基础架构，能力，研究计划以及使团队研究所需的网络。具有癌症生物学的物理科学。 PS-OC单独和共同将支持和培养一种新的跨学科环境和研究：（1）起源并测试新颖的，非传统的基于身体的基于身体的方法来理解和控制癌症； （2）生成正交的物理测量集，并将其与现有的癌症知识相结合； （3）开发和评估理论物理学方法，以提供癌症的全面和动态图景。最终，通过针对癌症过程的创新（也许是非传统）方法的协调，替代性，跨网络开发和测试，PS-OC将催化并产生新的知识和领域的新体系，以识别和定义关键方面“物理，化学和工程”在癌症过程中起作用。我们正在将物理和生命科学的调查人员组合在一起，以参与该中心。这包括五个湾区组织，具有全球认可和长期存在的能力和利益，并在物理科学，工程以及癌症研究和治疗中。我们还招募了来自两个外部机构的临床调查人员，以补充现有的专业知识并扩展我们项目的转化范围。