Language in Primary Progressive Aphasia

原发性进行性失语症的语言

• 批准号: 8292779
• 负责人: MAREK-MARSEL M MESULAM
• 金额: $ 60.95万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-05 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8292779
• 关键词: Address; Alzheimer' s Disease; American; Anomia; Anterior; Aphasia; Architecture; Area; Atrophic; Attention; Biological Markers; Biometry; Brain Diseases; Broca' s area; Cerebrum; Characteristics; Collaborations; Competence; Comprehension; Dementia; Deposition; Development; Diagnosis; Disease; Enrollment; Event-Related Potentials; Evolution; Eye Movements; Fostering; Frequencies; Frontotemporal Lobar Degenerations; Funding; Geographic Distribution; Goals; Grant; Heterogeneity; Impairment; International; Investigation; Language; Language Disorders; Learning; Left; Longitudinal Studies; Magnetic Resonance; Memory; Methodology; Modality; Names; Neurobiology; Neurodegenerative Disorders; Neuropsychology; Participant; Pathology; Patients; Phenotype; Physics; Primary Progressive Aphasia; Process; Productivity; Recovery; Recruitment Activity; Registries; Reporting; Research; Research Personnel; Resources; Retrieval; Risk Factors; Schedule; Semantics; Services; Site; Staging; Structure; Syndrome; Tauopathies; Temporal Lobe; Travel; Universities; Variant; Visit; base; cerebral atrophy; cohort; data sharing; design; follow-up; interdisciplinary approach; interest; international center; multidisciplinary; neurobehavior; neuroimaging; neuropathology; novel; programs; protein TDP-43; research study; web site

DESCRIPTION (provided by applicant): Primary progressive aphasia (PPA) is a brain disease that causes a gradual and increasingly more debilitating impairment of word usage and comprehension. Although it is being recognized with increasing frequency, PPA remains underserved with respect to research and patient services. This application seeks continued funding for a project that is the centerpiece of a comprehensive PPA Research Program at Northwestern University. The goal is to make maximal use of a unique cohort that has been recruited during the first 5 years of the project and to enroll new patients for hypothesis-driven investigations of naming, word comprehension, incidental memory and sentence processing with novel tasks designed by a multidisciplinary team of investigators with a track record of close collaboration and high productivity in PPA. We believe that this type of research program can best be achieved within the structure of a multidisciplinary approach such as the one we have established for this purpose, led by researchers in neuroimaging (Dr. Emily Rogalski), neurolinguistics (Dr. Cynthia Thompson), event-related potentials (Dr. Ken Paller), neuropsychology (Dr. Sandra Weintraub), neurobehavior (Dr. Marsel Mesulam), biostatistics (Dr. Alfred Rademaker) and Magnetic Resonance physics (Dr. Todd Parrish). For the next cycle, we chose specific aims that address the four core themes of this project: subtyping and temporal evolution of PPA, mechanisms of naming and semantic distortions, characteristics of fluency and grammatical competence, and anatomical substrates of language as inferred from the distribution of peak atrophy sites in patients. Within this framework, our primary aims will be 1. To complete a longitudinal study of a select subset of current participants in order to delineat the natural course of PPA and to characterize the evolution of its initial stages (Experiment 1). 2 To clarify the mechanisms of anomia with a cross-modal ERP experiment (Experiment 2). 3. To investigate dynamic perturbations of verb and sentence processing with on-line tasks using the methodology of ERP and eye movement recording (Experiments 3 and 4). 4. To identify the anatomical basis of material- and modality-specific distortions of learning in PPA (Experiment 5). 5. To foster the continued development of the International PPA Connection (IMPPACT) website, launched through the American Recovery and Reinvestment Act (ARRA), as an international collaborative patient and resource registry (ppaconnection.org). PUBLIC HEALTH RELEVANCE: Primary progressive aphasia (PPA) is a brain disease that causes a gradual and increasingly more debilitating impairment of word usage and comprehension. Although it is being recognized with increasing frequency, PPA remains underserved with respect to research and patient services. This application seeks continued funding for a project that is the centerpiece of a comprehensive PPA Research Program at Northwestern University.

描述（由申请人提供）：原发性进行性失语症（PPA）是一种脑部疾病，会导致词语使用和理解能力逐渐受损。尽管 PPA 得到越来越多的认可，但它在研究和患者服务方面的服务仍然不足。该申请为西北大学综合 PPA 研究计划的核心项目寻求持续资助。目标是最大限度地利用项目前 5 年招募的独特队列，并招募新患者进行假设驱动的命名、单词理解、附带记忆和句子处理的研究，以及由研究人员设计的新颖任务。多学科研究人员团队在 PPA 方面拥有密切合作和高生产力的记录。我们相信，这种类型的研究计划最好在多学科方法的结构中实现，例如我们为此目的建立的方法，由神经影像学（艾米丽·罗加尔斯基博士）、神经语言学（辛西娅·汤普森博士）研究人员领导，事件相关电位（Ken Paller 博士）、神经心理学（Sandra Weintraub 博士）、神经行为学（Marsel Mesulam 博士）、生物统计学（Alfred Rademaker 博士）和磁共振物理学（Todd Parrish 博士）。对于下一个周期，我们选择了解决该项目四个核心主题的具体目标：PPA 的子类型和时间演变、命名和语义扭曲的机制、流畅性和语法能力的特征以及从分布推断的语言的解剖基础患者的峰值萎缩部位。在此框架内，我们的主要目标是 1. 完成对当前参与者的选定子集的纵向研究，以描绘 PPA 的自然过程并描述其初始阶段的演变（实验 1）。 2 通过跨模式 ERP 实验阐明贫血的机制（实验 2）。 3. 使用 ERP 和眼动记录方法研究在线任务中动词和句子处理的动态扰动（实验 3 和 4）。 4. 确定 PPA 中学习材料和模式特定扭曲的解剖学基础（实验 5）。 5. 促进通过《美国复苏和再投资法案》(ARRA) 启动的国际 PPA 连接 (IMPPACT) 网站的持续发展，作为国际合作患者和资源登记处 (ppaconnection.org)。 公众健康相关性：原发性进行性失语症 (PPA) 是一种脑部疾病，会导致词语使用和理解能力逐渐受损，并且越来越严重。尽管 PPA 得到越来越多的认可，但它在研究和患者服务方面的服务仍然不足。该申请为西北大学综合 PPA 研究计划的核心项目寻求持续资助。