Language in Primary Progressive Aphasia

原发性进行性失语症的语言

基本信息

批准号：
7407382
负责人：
MAREK-MARSEL M MESULAM
金额：
$ 43.96万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-05-01 至 2012-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7407382
关键词：
Address Adult Alzheimer&apos s Disease Aphasia Area Attention Autopsy Behavior Biometry Brain Brain Injuries Catchment Area Categories Cerebrum Classification Clinic Clinic Visits Clinical Cognitive Collaborations Collection Compatible Complex Condition Country DNA Data Base Management Degenerative Disorder Diagnosis Diffusion Magnetic Resonance Imaging Disease Disease Progression Electrophysiology (science)Event-Related Potentials Funding Future Goals Image Investigation Knowledge Language Language Disorders Letters Linguistics Literature Memory impairment Methods Modality Molecular Molecular Genetics Names Neuroanatomy Neurobiology Neurocognitive Neurodegenerative Disorders Neurologic Neurology Neurons Neuropsychology Numbers Onset of illness Participant Patients Primary Progressive Aphasia Process Psycholinguistics Qualifying Recruitment Activity Relative (related person)Reporting Research Research Infrastructure Research Personnel Resources Sampling Schedule Semantics Seminal Services Source Specialized Center Specificity Speech Pathology Staging Stroke Structure Symptoms Syndrome Therapeutic Therapeutic Intervention Travel Visit Word Processing Work aphasic base cerebrovascular lesion interdisciplinary approach lexical retrieval morphometry neurobehavior neuroimaging neuron loss novel phonology programs research study

项目摘要

DESCRIPTION (provided by applicant): The goal of the project is to investigate the language disorder and treatment modalities in primary progressive aphasia (PPA). The approach is multidiscipiinary and will include experts in neurology, speech pathology, neuropsychology, electrophysiology and imaging. The methods will include chronometric neurolinguistic investigations, event-related potentials, voxel based morphometry and diffusion tensor imaging. Several reasons justify a research program focusing on PPA. First, PPA constitutes the only adult-onset disease that selectively attacks the language network in the brain. Second, PPA patients suffer from aphasic disturbances that deserve to be characterized more fully, especially since the early stages of the disease are compatible with effective therapeutic interventions. Third, the slow dissolution of language abilities in PPA offers a unique setting, not duplicated by any other aphasic disturbance, for investigating the neurocognitive organization of language. Fourth, the relative scarcity of PPA patients, the temporal progression of the disease, and the wide catchment area needed to recruit a sufficient number of patients create a situation where the integrated work of a multidiscipiinary team is the most efficient way to conduct a research program focusing on this syndrome. The proposal comes from a team of investigators who have worked on PPA for many years and have collaborated extensively. The patients will be recruited from a clinic that is one of the world's most readily recognized referral centers for PPA. The work will use the resources of the Northwestern Alzheimer's Disease Center in a way that will enhance economy of effort.

描述（由申请人提供）：该项目的目标是研究原发性进行性失语症（PPA）的语言障碍和治疗方式。该方法是多学科的，包括神经病学、言语病理学、神经心理学、电生理学和影像学方面的专家。这些方法将包括计时神经语言学研究、事件相关电位、基于体素的形态测量和扩散张量成像。有几个理由证明专注于 PPA 的研究计划是合理的。首先，PPA 是唯一一种选择性攻击大脑语言网络的成人发病疾病。其次，PPA 患者患有失语症，值得更全面地表征，特别是因为该疾病的早期阶段与有效的治疗干预相一致。第三，PPA 中语言能力的缓慢消解为研究语言的神经认知组织提供了一个独特的环境，任何其他失语症都不会重复。第四，PPA 患者相对稀缺、疾病的时间进展以及招募足够数量患者所需的广泛服务区域创造了这样一种情况：多学科团队的综合工作是开展研究计划的最有效方式专注于这种综合症。该提案来自一个在 PPA 领域工作多年并进行广泛合作的研究人员团队。这些患者将从一家诊所招募，该诊所是世界上最受认可的 PPA 转诊中心之一。这项工作将以提高工作效率的方式利用西北阿尔茨海默病中心的资源。