Analytical Biochemistry Shared Resource

分析生物化学共享资源

• 批准号: 8369394
• 负责人: MICHELE CARBONE
• 金额: $ 10.69万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8369394
• 关键词: Analytical Biochemistry; Analytical Chemistry; Biological Assay; Cancer Center; Cancer Center Support Grant; Chemicals; Clinical Markers; Collaborations; Computers; Consultations; Custom; Data; Equipment; Feedback; Floor; Funding; Future; Grant; Growth; Hawaii; Hazardous Substances; Human Resources; Immunoassay; Institutes; Laboratories; Laboratory Technicians; Malignant Neoplasms; Mass Spectrum Analysis; Methods; Molecular; Monitor; Peer Review; Productivity; Protocols documentation; Publications; Regulation; Research Activity; Research Personnel; Resource Sharing; Resources; Robin bird; Safety; Services; Speed; Techniques; Technology; Testing; Universities; Update; anticancer research; base; cost; cost effective; design; flexibility; improved; instrumentation; liquid chromatography mass spectrometry; member; programs; quality assurance; small molecule; square foot

This facility, operating since 1990, provides cost-effective and accurate chemical analyses for molecules relevant to cancer research of Cancer Center (CC) investigators. It is also a base for consultation related to the quantitation of analytes and strategies in analytical chemistry. Services and expertise in advanced methods are available including state-of-the-art techniques, particularly liquid chromatography mass spectrometry (LCMS) and multiplexed immunoassays. In addition, routine analyses and determinations of clinical markers are offered to investigators. A host of new assays have been implemented in the current cycle due to needs of CC members. No other laboratories are available to provide many of these services in the State of Hawai'i, particularly regarding type, speed, cost, and combinations of assays, many of which are custom designed by this core to fulfill the specific requirements of CC projects. The high quality of services is continually monitored by taking part in internal and external quality assurance programs including the participation in round robin tests organized by the National Institute of Standards and Technology. The availability of this core provides state-of-the-art services, improves feedback to the investigators, stimulates inter-disciplinary collaborations, and provides cost effective service to CC investigators. The current use at full capacity is anticipated to continue for the foreseeable future. Newly funded projects requiring services of the resource will outnumber projects terminating in the coming years. Equipment obtained through the CCSG support grant in the current cycle has greatly enhanced the potential of this resource. This facility has shown remarkable growth: its productivity increased by 84% since the last cycle and has grown accordingly in personnel and revenue. The great value of this core is underscored by a total of 79 cancer related peer reviewed publications during FY06-11 that involved services by the ABSR (58% inter-programmatic, 13% intra-programmatic).

该设施自 1990 年开始运营，为癌症中心 (CC) 研究人员的癌症研究相关分子提供经济有效且准确的化学分析。它也是分析化学中分析物定量和策略相关咨询的基础。我们提供先进方法的服务和专业知识，包括最先进的技术，特别是液相色谱质谱 (LCMS) 和多重免疫测定。此外，还向研究人员提供临床标志物的常规分析和测定。由于 CC 成员的需要，本周期中实施了许多新的检测方法。在夏威夷州没有其他实验室可以提供许多此类服务，特别是在类型、速度、成本和检测组合方面，其中许多是由该核心定制设计的，以满足 CC 项目的特定要求。通过参加内部和外部质量保证计划（包括参加美国国家标准与技术研究所组织的循环测试）来持续监控高质量的服务。该核心的可用性提供了最先进的服务，改善了对调查人员的反馈，促进了跨学科合作，并为 CC 调查人员提供了具有成本效益的服务。目前的满负荷使用预计在可预见的未来仍将继续。需要资源服务的新资助项目数量将超过未来几年终止的项目数量。本周期通过CCSG支持拨款获得的设备大大增强了该资源的潜力。该工厂显示出显着的增长：自上一个周期以来，其生产率提高了 84%，人员和收入也相应增长。 2006-11 财年期间共有 79 篇癌症相关同行评审出版物强调了这一核心的巨大价值，这些出版物涉及 ABSR 的服务（58% 是项目间服务，13% 是项目内服务）。