NOVEL REGIMEN FOR CONTROLLED OVARIAN STIMULATION IN MACAQUES

控制猕猴卵巢刺激的新疗法

• 批准号: 7715921
• 负责人: Mary B Zelinski
• 金额: $ 5.55万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715921
• 关键词: Assisted Reproductive Technology; Computer Retrieval of Information on Scientific Projects Database; Daily; Development; Follicle Stimulating Hormone; Funding; Gonadotropins; Grant; Half-Life; Human; Infertility; Institution; Intramuscular; Macaca; Modeling; Ovarian Stimulations; Ovulation Induction; Patients; Preparation; Production; Protocols documentation; Recombinant Gonadotropin; Recombinants; Research; Research Personnel; Resources; Source; Subcutaneous Injections; Testing; Treatment Protocols; United States National Institutes of Health; Woman; animal resource; day; in vivo; irritation; mimetics; neutralizing antibody; nonhuman primate; novel; preclinical study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Recombinant human gonadotropins (e.g., follicle stimulating hormone, FSH) are routinely used to promote follicular development for assisted reproductive technologies in nonhuman primates and women. Because of their relatively short half-life in vivo, the available preparations are administered as daily intramuscular or subcutaneous injections, often for 8-14 day intervals, which can be associated with patient discomfort, local irritation and decreased compliance in women. Of importance to nonhuman primate infertility research, recombinant human gonadotropins elicit eventual production of neutralizing antibodies that precludes further stimulation protocols and efficient use of a valuable animal resource. Current developments in gonadotropin therapy for follicular stimulation or ovulation induction in infertile women focus on creating recombinant gonadotropins with longer half-lives in vivo, or gonadotropin mimetics. Therefore, a pre-clinical study is underway to test the efficacy of a novel gonadotropin for follicular stimulation in a nonhuman primate model.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 重组人促性腺激素（例如，促卵泡激素，FSH）通常用于促进卵泡发育，以促进非人类灵长类动物和女性的辅助生殖技术。由于其体内的半衰期相对较短，因此通常以每天的肌肉内或皮下注射为8-14天的间隔，这可能与患者不适，局部刺激和女性的依从性下降有关。 对于非人类灵长类动物不孕研究的重要性，重组人促性腺激素最终会产生中和抗体的产生，这些抗体排除了进一步的刺激方案和有效利用有价值的动物资源。 促性腺激素治疗的当前发展的卵泡刺激或排卵诱导的发展专注于在体内产生更长的半衰期的重组促性腺激素，或者是促性腺激素模拟物。 因此，正在进行一项临床前研究，以测试新型促性腺激素对非人类灵长类动物模型中卵泡刺激的功效。