Improving stone disease treatment by accurate phenotyping and risk stratification

通过准确的表型分析和风险分层改善结石病的治疗

• 批准号: 8598968
• 负责人: John C Lieske
• 金额: $ 200万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-29 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8598968
• 关键词: Address; Basic Science; Biology; Calculi; Clinic; Clinical; Clinical Research; Clinical Sciences; Collection; Crystallization; Development; Disease; Dose; Drosophila genus; Epidemiology; Fostering; Funding; Genetic; Goals; Image; Kidney Calculi; Knowledge; Laboratories; Lesion; Methods; Modeling; Molecular; Monitor; Nephrolithiasis; Nephrology; Oxalates; Patient Care; Patients; Phenotype; Physiology; Proteomics; Radiology Specialty; Recurrence; Research; Resources; Risk; Scientist; Stratification; Techniques; Translational Research; Tubular formation; Urology; Work; clinical care; clinically relevant; experience; genetic epidemiology; high risk; improved; innovation; multidisciplinary; novel; novel diagnostics; public health relevance; tool

DESCRIPTION (provided by applicant): The overall goals of the Mayo Clinic Urology O'Brien Research Center are to develop new diagnostic strategies in order to accurately phenotype patients and thus apply improved individualized management strategies. We will pursue these goals via 4 interlinked multidisciplinary projects. Important and timely aims of the Mayo Clinic O'Brien Urology Research Center include: 1) Develop and validate a comprehensive low-dose stone-characterization exam using clinical dual-energy CT techniques in order to predict stone fragility, and to develop new CT methods capable of detecting the earliest possible precursor lesions. 2) Determine factors that produce NL precursor lesions including Randall's plaques and tubular plugs. 3) Define specific factors that increase the risk of kidney stones and their recurrence, and develop clinical prediction tools to help clinicians identify high-risk patients. 4) Define environmental and genetic factors that influence oxalate transport and crystallization in a novel high throughput Drosophila model. This proposal is highly responsive to the O'Brien Urology Research Center RFA bringing together truly multidisciplinary group of experienced clinicians and basic scientists to conduct translational research. Each project is multidisciplinary, and clinical, translational and basic research is each well represented. Further, all projects have clear clinical relevance and will impact our understanding of nephrolithiasis and our ability to care for patients. The Mayo Clinic has a unique collection of resources such as the Rochester Epidemiology Project; funded laboratories with expertise in genetics, proteomics and transport physiology; large patient volumes; and the CT Imaging Innovation Center which can be applied to this common yet understudied disorder. Through this O'Brien Center, existing clinical and basic science expertise in urology, nephrology, radiology, epidemiology, genetics and physiology will work in synergy to foster rapid progress.

描述（由申请人提供）：梅奥诊所泌尿外科研究中心的总体目标是制定新的诊断策略，以便准确表型患者，从而采用改进的个性化管理策略。我们将通过4个相互联系的多学科项目实现这些目标。 Mayo诊所O'Brien泌尿科研究中心的重要和及时目标包括： 1）使用临床双能CT技术来开发和验证全面的低剂量石材特征化检查，以预测石材脆弱性，并开发能够检测最早可能的前体病变的新CT方法。 2）确定产生NL前体病变的因素，包括Randall的斑块和管状塞。 3）定义特定因素，以增加肾结石及其复发的风险，并开发临床预测工具，以帮助临床医生识别高危患者。 4）定义在新型高吞吐果蝇模型中影响草酸盐转运和结晶的环境和遗传因素。 该提案对奥布莱恩泌尿外科研究中心RFA的反应非常敏感，将真正的多学科临床医生和基础科学家组成的真正多学科小组进行了转化研究。每个项目都是多学科的，临床，翻译和基础研究都有很好的代表。此外，所有项目都具有明确的临床相关性，并将影响我们对肾物石病的理解以及我们护理患者的能力。梅奥诊所拥有独特的资源集合，例如罗切斯特流行病学项目；具有遗传学，蛋白质组学和运输生理学专业知识的资助实验室；大型患者量；以及可以应用于这种常见但经过研究的疾病的CT成像创新中心。通过这个奥布莱恩中心，现有的泌尿外科，肾脏学，放射学，流行病学，遗传学和生理学方面的临床和基础科学专业知识将在协同作用中起作用，以促进快速进步。