Biology at birth: the role of infancy in providing the foundation for lifetime success

出生时的生物学：婴儿期为终身成功奠定基础的作用

• 批准号: 10608856
• 负责人: Rebecca Z German
• 金额: $ 1万
• 依托单位: NORTHEAST OHIO MEDICAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10608856
• 关键词: Address; Adolescent; Adult; Anatomy; Area; Basic Science; Behavioral; Biological Models; Biological Sciences; Biology; Birth; Cardiovascular system; Childhood; Clinical; Clinical Research; Collaborations; Comparative Biology; Development; Discipline; Education; Educational workshop; Elements; Endocrine; Environment; Family suidae; Fertilization; Foundations; Functional disorder; Future; Goals; Guidelines; Human; Individual; Infant; Institution; Journals; Justice; Life; Manuscripts; Methodology; Mission; Modeling; Musculoskeletal; Neurologic; Organism; Output; Paper; Participant; Peer Review; Performance; Perinatal; Phenotype; Physiological; Physiology; Publishing; Rehabilitation therapy; Research; Research Personnel; Rodent; Role; Scientist; Secure; Shapes; Sheep; Societies; Specialist; System; Time; Training; Work; clinically relevant; comparative; equity, diversity, and inclusion; experience; fitness; infancy; innovation; meetings; novel; pediatrician; posters; prenatal; recruit; success; symposium

Infancy is a perilous time for any organism, with significant changes as individuals move from the maternal protected environment to the outside world. Massive anatomical, behavioral, and physiologic changes start at birth, and continue through development, with implications for adult survival and success. We have organized a symposium that addresses infancy from an integrated perspective, highlighting that this period of time in any individual’s life can shape its entire future. While neonatologists, pediatricians, and pediatric specialists across all clinical subdisciplines are broadly and deeply trained, less integration exists amongst the basic scientists who provide the substrate for clinical research and advances in treatment and rehabilitation. Our goal is to bring together basic science and clinical researchers across various life science disciplines for conversation, collaboration, and interaction across disciplinary boundaries as a way of promoting novel and innovative research at this specific moment of development. We propose three activities, which align with our Specific Aims: organize Main and Supplemental symposia on infancy at 2023 SICB meeting (SA1); a organize lunchtime workshop for participants and trainees (SA2); and publish an issue of Integrative & Comparative Biology including all platform and poster presenters, a synthetic introduction, and an overview and conclusions of the workshop (SA3). The main symposium includes three general topics: (1) how the prenatal environment shapes infant phenotype; (2) perinatal physiology and development; (3) the longitudinal impacts of infant experiences on phenotype and performance. This symposium as already been accepted for the Society of Comparative and Integrative Biology 2023 meeting, and our 11 speakers have accepted, including a commitment to submit a manuscript for peer review in early 2023 (per society and journal guidelines). We have begun recruiting speakers for our Supplemental Symposium and poster sessions (open to anyone within the society). The speakers who have committed to this symposium span multiple physiologic systems (including neurological, cardiovascular, musculoskeletal, digestive, endocrine) and multiple model species (humans, pigs, sheep, rodents). We anticipate that the discussions among individuals representing the three topic headings will galvanize interactions and cross- fertilizations. This in turn will promote new and integrative work on the both the underlying normal physiology and the specific pathophysiologies that characterize infancy.

婴儿期是任何生物体的危险时间，随着个人的移动而发生重大变化 从母体保护的环境到外界。大规模解剖学，行为， 生理变化从出生开始，并继续发展，对 成人生存和成功。我们已经组织了一个针对婴儿期的研讨会 综合的观点，强调了任何个人生活中的这段时间都可以塑造其 而新生儿学家，儿科医生和儿科专家在所有临床上 子学科是广泛和深入训练的，在基本科学家中存在较少的融合 谁为临床研究和治疗和康复进展提供了基材。我们的 目标是将各种生活科学的基础科学和临床研究人员汇集在一起 跨学科界限的对话，协作和互动的学科作为一个 在这一特定发展时刻促进新颖和创新研究的方式。我们 提案三个活动，与我们的具体目的保持一致：组织主要和补充 2023年SICB会议（SA1）的婴儿期研讨会；组织午餐时间研讨会 参与者和学员（SA2）；并发布综合和比较生物学问题 包括所有平台和海报演示者，合成介绍以及概述和 研讨会的结论（SA3）。主要研讨会包括三个一般主题：（1） 产前环境塑造婴儿表型； （2）围产期生理学和发育； （3） 婴儿经历对表型和表现的纵向影响。 该研讨会已经被接受了比较和综合社会 生物学2023会议，我们的11位发言人接受了 2023年初的同行评审手稿（根据社会和期刊指南）。我们已经开始 为我们的补充研讨会和海报会议招募演讲者（向内部的任何人开放 致力于此研讨会的辐条剂跨越多个生理学 系统（包括神经系统，心血管，肌肉骨骼，消化，内分泌）和 多种模型物种（人类，猪，绵羊，啮齿动物）。我们预计讨论 在代表三个主题标题的个体中 肥料。这反过 生理学和表征婴儿期的特定病理生理学。