Improving stone disease treatment by accurate phenotyping and risk stratification

通过准确的表型分析和风险分层改善结石病的治疗

• 批准号: 9135351
• 负责人: John C Lieske
• 金额: $ 100万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-29 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9135351
• 关键词: Address; Biology; Clinic; Clinical; Development; Disease; Dose; Epidemiology; Goals; Health; Kidney Calculi; Knowledge; Lesion; Methods; Molecular; Monitor; Nephrolithiasis; Oxalates; Patients; Phenotype; Recurrence; Research; Risk; Stratification; Techniques; Tubular formation; Urology; clinical care; high risk; improved; multidisciplinary; novel diagnostics; personalized management; tool; Address; Biology; Clinic; Clinical; Development; Disease; Dose; Epidemiology; Goals; Health; Kidney Calculi; Knowledge; Lesion; Methods; Molecular; Monitor; Nephrolithiasis; Oxalates; Patients; Phenotype; Recurrence; Research; Risk; Stratification; Techniques; Tubular formation; Urology; clinical care; high risk; improved; multidisciplinary; novel diagnostics; personalized management; tool

DESCRIPTION (provided by applicant): The overall goals of the Mayo Clinic Urology O'Brien Research Center are to develop new diagnostic strategies in order to accurately phenotype patients and thus apply improved individualized management strategies. We will pursue these goals via 4 interlinked multidisciplinary projects. Important and timely aims of the Mayo Clinic O'Brien Urology Research Center include: 1) Develop and validate a comprehensive low-dose stone-characterization exam using clinical dual-energy CT techniques in order to predict stone fragility, and to develop new CT methods capable of detecting the earliest possible precursor lesions. 2) Determine factors that produce NL precursor lesions including Randall's plaques and tubular plugs. 3) Define specific factors that increase the risk of kidney stones and their recurrence, and develop clinical prediction tools to help clinicians identify high-risk patients.

描述（由申请人提供）：梅奥诊所泌尿外科研究中心的总体目标是制定新的诊断策略，以便准确表型患者，从而采用改进的个性化管理策略。我们将通过4个相互联系的多学科项目实现这些目标。 Mayo诊所O'Brien泌尿科研究中心的重要和及时目标包括： 1）使用临床双能CT技术来开发和验证全面的低剂量石材特征化检查，以预测石材脆弱性，并开发能够检测最早可能的前体病变的新CT方法。 2）确定产生NL前体病变的因素，包括Randall的斑块和管状塞。 3）定义特定因素，以增加肾结石及其复发的风险，并开发临床预测工具，以帮助临床医生识别高危患者。