Notre Dame Study of Health & Well-being

圣母大学健康研究

基本信息

批准号：
8187647
负责人：
Cindy S Bergeman
金额：
$ 61.1万
依托单位：
UNIVERSITY OF NOTRE DAME
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-09-15 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8187647
关键词：
Accounting Adult Affect Age Biological Biology Caregiver Burden Chronic Coupling Data Data Set Development Disease Elderly Emotional Emotions Equilibrium Event Exposure to Goals Growth Health Hydrocortisone Individual Individual Differences Investigation Lead Life Life Cycle Stages Life Stress Link Longevity Measurement Mental Health Modeling Morbidity - disease rate Neighborhoods Neurosecretory Systems Outcome Pathway interactions Patient Self-Report Personal Satisfaction Personality Persons Physiological Play Process Quality of life Questionnaires Recovery Resistance Resources Risk Role Sampling Social support Stress Surveys Systems Analysis Techniques Testing Time Variant cohort emotional experience experience flexibility innovation interest longitudinal design middle age parent project physical conditioning psychosocial resilience response scaffold stress resilience young adult

项目摘要

DESCRIPTION (provided by applicant): This proposal is for a competitive renewal of the Notre Dame Study of Health and Well-being (NDHWB; R01 AG023571) to support an investigation of the myriad pathways through which life stress contributes to the physical and mental health across the adult lifespan, and of the resilience mechanisms that may protect those individuals from the ill-effects of exposure to adversity. The existing data set is unparalleled in the richness of stress measurement, collected over multiple time points spanning 5 years and including 5 annual questionnaire assessments and three 56-day data bursts (Years 1, 3, & 5; two in the midlife cohort). These data allow us to examine multiple forms of adversity, their common and distinctive linkages, with subsequent indicators of health and well-being. With the present proposal, we broaden the study by collecting additional longitudinal data (expanding the study to 10 years), adding 2 additional data bursts to the later life cohort (Years 7 & 9) and 3 bursts in the mid-life cohort (Years 6, 8, & 10). We extend the study by adding a young adult cohort (ages 18 - 40), assessing them with 5 annual questionnaires and 3 data bursts (years 1, 3, & 5) to better understand how these factors are developed and maintained in adulthood. Finally, we propose to add two 10-day bursts of cortisol assessments (collected 3 X day) on a subset of subjects (50 per cohort) to capture physiological responses to stress. The overarching goal of the expanded project is twofold: to comprehensively and precisely detail the types and qualities of life stress that may initiate the cascade of perceptual, emotional, and biological responses that can lead to disorder and disease, and to examine resilience resources that protect against them. PUBLIC HEALTH RELEVANCE: In this competitive renewal, we propose to expand and significantly enhance the Notre Dame Study of Health & Well-Being (NDHWB) by including (1) 5 more years of intensive longitudinal assessments (including 5 yearly assessments and two separate 56-day bursts (three for the midlife), which will culminate in 10 years of survey data for the later life sample (9 for the mid-life cohort) and 5 56-day daily bursts; (2) a new young adult cohort (18-39) to the study (assessed yearly for 5 years and completing 3 56-day data bursts); and (3) two 10-day bursts of cortisol assessments (collected 3 X day) on a subset of subjects (50 from each cohort). This will allow for the assessment of interindividual differences in intraindividual variability and change across the adult lifespan in the risk and resilience resources that lead some to thrive and be well, and others to experience detrimental physical and mental health consequences.

描述（由申请人提供）：本提案旨在竞争性地更新圣母大学健康与福祉研究（NDHWB；R01 AG023571），以支持对生活压力影响身心健康的多种途径进行调查整个成年人的一生，以及可以保护这些人免受逆境不良影响的复原机制。现有数据集在压力测量的丰富性方面是无与伦比的，收集了跨越 5 年的多个时间点，包括 5 次年度问卷评估和 3 个 56 天的数据突发（第 1 年、第 3 年和第 5 年；其中两个在中年队列）。这些数据使我们能够研究多种形式的逆境、它们的共同和独特的联系，以及随后的健康和福祉指标。根据目前的建议，我们通过收集额外的纵向数据（将研究范围扩大到 10 年）来扩大研究范围，在晚年队列（7 岁和 9 岁）中添加 2 个额外的数据突发，在中年队列（7 岁和 9 岁）中添加 3 个数据突发。 6、8 和 10)。我们通过添加一个年轻人队列（18 - 40 岁）来扩展研究，通过 5 份年度调查问卷和 3 次数据爆发（第 1、3 和 5 年）对他们进行评估，以更好地了解这些因素在成年后如何发展和维持。最后，我们建议对一部分受试者（每组 50 名）添加两次为期 10 天的皮质醇评估（收集 3 X 天），以捕捉对压力的生理反应。扩展项目的总体目标是双重的：全面而准确地详细描述生活压力的类型和质量，这些压力可能引发一系列感知、情感和生物反应，从而导致紊乱和疾病；并检查保护的弹性资源。反对他们。公共健康相关性：在这次竞争性更新中，我们建议通过包括 (1) 再进行 5 年的密集纵向评估（包括 5 年年度评估和两个单独的 56日爆发（中年为 3 次），最终将产生晚年样本的 10 年调查数据（中年队列为 9 年）和 5 个 56 天的每日数据(2) 一个新的年轻成人队列 (18-39) 进行研究（每年进行一次评估，持续 5 年并完成 3 个 56 天的数据突发）；以及 (3) 两次为期 10 天的皮质醇评估（收集 3 次）天）对一个受试者子集（每个队列 50 名）进行评估，这将允许评估个体间变异性以及成人生命周期中风险和复原力的变化。这些资源导致一些人茁壮成长并保持健康，而另一些人则遭受有害的身心健康后果。