University of Colorado Denver Adolescent Trials Network Unit

科罗拉多大学丹佛分校青少年试验网络单位

• 批准号: 8463420
• 负责人: Elizabeth Jane McFarland
• 金额: $ 42.64万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-07 至 2016-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8463420
• 关键词: AIDS prevention; Achievement; Adolescent; Adolescent Medicine Trials Network; Advocacy; Age; Behavior; Caring; Clinical Trials Network; Collaborations; Colorado; Communities; Data; Data Quality; Disease Progression; Environment; Goals; HIV; HIV Infections; Health; Incidence; Individual; Infection; Intervention; Lead; Leadership; Life; Methods; Multi-Institutional Clinical Trial; Operations Research; Pediatric Hospitals; Performance; Positioning Attribute; Primary Prevention; Protocols documentation; Quality of life; Recruitment Activity; Research; Risk; Secondary Prevention; Services; Sexually Transmitted Diseases; Site; Universities; Work; Youth; experience; improved; innovation; metropolitan; operation; prevent; programs; tertiary prevention; transmission process; young adult

DESCRIPTION (provided by applicant): An estimated 1.2 million new HIV infections occur among 15 to 24 year olds annually in the world. In the US, the HIV incidence rate in youth is among the highest with 34% of all new infections occurring among 13-29 year olds in 2006. Data from the Colorado Department of Health and Environment indicate an annual increase in the number of young people acquiring HIV infection as well as a steady increase in the number of youth with other sexually transmitted infections, indicating that a large number of adolescents and young adults are participating in behavior that puts them at risk of HIV infection. The goal of this proposal is to establish a new Adolescent Trials Network Unit in metropolitan Denver. The unit will participate fully with the ATN operations to conduct studies focused on primary, secondary and tertiary prevention of HIV infection in adolescents and young adults (age 12-24yr). The work will be take place primarily at The Children's Hospital which is affiliated with University of Colorado Denver as well as in the communities where at-risk youth receive services. The applicant has over 18 years of experience participating in multi-centered clinical trials for HIV infected and at-risk individuals. Our research unit has established a record of achievement in regard to data quality and contributions to the scientific agenda of the clinical trials networks in which we have participated. CHIP Youth Project is a robust program for the care of HIV-infected youth and is the lead agency in Denver's collaborative community consortium, the Youth HIV Advocacy Coalition (YHAC), dedicated to the prevention of HIV. These attributes position our site to be a highly productive ATN unit. The specific aims of the project will be to 1) Integrate Adolescent Trials Network protocols into the research and care operation of CHIP/CYP; 2) Expand and enhance existing community collaborations resulting in community mobilization to reduce HIV transmission; 3) Use innovation strategies to recruit and retain more than 75 HIV infected and 125 HIV at-risk adolescents and young adults; 4) Maintain outstanding performance as an ATN unit; 5) Contribute to the ATN scientific agenda; 6) Develop methods to assure consumer input to scientific agenda and research operations. RELEVANCE: The research conducted in this proposal, in collaboration with other research units and the ATN leadership, will lead to improved interventions to prevent HIV transmission among youth (age 12-24 years) and to better care to prevent disease progression and improve quality of life for youth living with HIV.

描述（由申请人提供）：估计全世界每年 15 至 24 岁的人群中出现 120 万新的 HIV 感染者。在美国，青少年的艾滋病毒发病率是最高的，2006 年所有新感染者中有 34% 发生在 13-29 岁的人群中。科罗拉多州卫生与环境部的数据表明，青少年人数逐年增加感染艾滋病毒的人数以及患有其他性传播感染的青少年人数稳步增加，表明大量青少年和年轻人正在参与使他们面临感染艾滋病毒风险的行为。该提案的目标是在丹佛市建立一个新的青少年试验网络单位。该部门将充分参与 ATN 的运作，开展针对青少年和年轻人（12-24 岁）艾滋病毒感染的一级、二级和三级预防的研究。这项工作将主要在科罗拉多大学丹佛分校附属儿童医院以及高危青少年接受服务的社区进行。申请人拥有超过18年参与针对HIV感染者和高危人群的多中心临床试验的经验。我们的研究单位在数据质量和对我们参与的临床试验网络的科学议程的贡献方面取得了成就记录。 CHIP 青年项目是一项针对感染艾滋病毒的青年的强有力的计划，是丹佛合作社区联盟青年艾滋病毒倡导联盟 (YHAC) 的牵头机构，致力于预防艾滋病毒。这些属性使我们的网站成为一个高生产力的 ATN 单位。该项目的具体目标是 1) 将青少年试验网络协议整合到 CHIP/CYP 的研究和护理运营中； 2) 扩大和加强现有社区合作，动员社区减少艾滋病毒传播； 3) 利用创新战略招募并留住超过 75 名艾滋病毒感染者和 125 名艾滋病毒高危青少年和年轻人； 4) 作为ATN单位保持出色的业绩； 5) 为ATN科学议程做出贡献； 6) 制定方法以确保消费者对科学议程和研究活动的投入。 相关性：本提案中与其他研究单位和 ATN 领导层合作进行的研究将改进干预措施，预防青少年（12-24 岁）中的艾滋病毒传播，并提供更好的护理以防止疾病进展并提高治疗质量。感染艾滋病毒的青少年的生活。