PACTG P1055: PSYCHIATRIC CO-MORBIDITY IN PERINATALLY HIV CHILDREN AND ADOLESCENT

PACTG P1055：围产期 HIV 儿童和青少年的精神共病

• 批准号: 7605122
• 负责人: Elizabeth Jane McFarland
• 金额: $ 4.48万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605122
• 关键词: 18 year old; Adolescent; Age; Brain; Caregivers; Child; Computer Retrieval of Information on Scientific Projects Database; Control Groups; Development; Disease; Follow-Up Studies; Frequencies; Funding; Gender; Grant; HIV; Institution; Interview; Measures; Mental Health; Mental disorders; Morbidity - disease rate; Observational Study; Parents; Penetration; Prevalence; Purpose; Questionnaires; Research; Research Design; Research Personnel; Resources; Rest; Risk; Sampling; Series; Severities; Source; Structure; Study Subject; Symptoms; Therapeutic; Time; Treatment Protocols; United States National Institutes of Health; Visit; cohort; follow-up; male; neurotropic virus

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. P1055 is a multicenter, non-treatment, observational study designed to better understand the impact of HIV on the development of psychiatric symptomatology in a cohort of perinatally HIV-infected children and adolescents, when compared to a cohort of demographically matched control subjects. The significance of this study rests in its focus on a potentially high-risk sample exposed to a neurotropic virus and therapeutic regimens with altered penetration into the brain. For the purposes of this study, subjects in the control group will be frequency matched (i.e., will be matched with the same percentage of 6 to 12 to 12 to 18 year-old males) to those in the HIV-infected group by gender and age strata. Subjects will not receive treatment in this study; subjects and their parents/primary caregivers will respond to a series of questionnaires/measures which will be used to assess the prevalence and severity of current psychiatric symptoms and disorders and to assess changes over time. The study is divided into two components, the prevalence and severity of current psychiatric disorders and symptoms (Mental Health Component at the first study visit) and changes in symptomatology over time (Follow-Up Component at the second and third study visits). In addition, a subset of perinatally HIV-infected and control subjects (100-120 subjects from each group) and their parents/primary caregivers will receive additional measures, in the form of semi-structured psychiatric interviews, to further identify the differential frequency of psychiatric symptoms in HIV-infected children or adolescents and control subjects and to establish the feasibility of a long-term follow-up study.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 P1055是一项多中心，未进行的观察性研究，旨在更好地了解艾滋病毒对与人口统计学匹配的对照组相比，相比，与人口统计学匹配的对照组相比，相比，艾滋病毒对精神病症状学的影响。 这项研究的意义在于它的重点是暴露于神经旋转病毒和治疗方案的潜在高风险样本，并且渗透到大脑中。 出于本研究的目的，对照组中的受试者将通过性别和年龄层与HIV感染组中的受试者匹配（即，将与6至12至12岁的男性相同的比例与6至12至12岁的男性匹配）。 受试者将在这项研究中无法接受治疗；受试者及其父母/主要护理人员将对一系列问卷/措施做出反应，这些问卷/措施将用于评估当前精神症状和疾病的患病率和严重性，并随着时间的推移评估变化。 该研究分为两个组成部分，分为当前精神疾病和症状的患病率和严重程度（第一次研究访问时的心理健康成分）和随着时间的流逝（第二和第三次研究访问中的随访部分）的变化。 此外，以半结构化精神访谈的形式获得了一部分受HIV感染和控制受试者（每组的100-120名受试者）及其父母/主要护理人员将获得其他措施，以进一步确定HIV感染的儿童或刚刚受试者的精神症状的差异频率，并建立了一项长期的载人性研究。