Health Effects and Geochemistry of Arsenic and Manganese

砷和锰的健康影响和地球化学

基本信息

批准号：
8717867
负责人：
Joseph H Graziano
金额：
$ 1.63万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-08-20 至 2014-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8717867
关键词：
3-Dimensional Adolescent Adult Age Arsenic Asia Automobile Driving Bangladesh Biological Markers Biomedical Research Brain Carbon Cardiovascular Diseases Child Child health care Chronic Chronic Disease Cohort Studies Communication Communities Conceptions County Coupled DNA Methylation Data Disease Disease Outcome Dose Environmental Policy Epidemiologic Studies Epigenetic Process Equilibrium Goals Government Government Agencies Grant Hazardous Substances Health Histones Household In Situ Incidence Individual Injection of therapeutic agent Integration Host Factors Intelligence Intervention Investigation Iron Irrigation Knowledge Laboratories Literature Longitudinal Studies Lung Lung diseases Maine Manganese Maps Methods National Institute of Environmental Health Sciences New Jersey Oxalic Acids Participant Precipitation Process Public Health Pump Research Research Project Grants Research Support Research Training Risk Scientist Services Signal Recognition Particle Site Soil Source Structure Sulfur Superfund Techniques Testing Trace metal Training Programs Translating Translational Research Universities Water Water Supply Woman Work base cohort data management dosimetry drinking water executive function field study follow-up improved interest iron oxide land use magnetite ferrosoferric oxide microbial mortality neuropsychological novel strategies nutrition operation programs prospective pulmonary function remediation response scale up superfund site

项目摘要

This proposal is submitted in response to RFA-ES-10-010, entitled "Superfund Hazardous Substance Research and Training Program (P42)." The proposed work involves substantial work at the single most serious arsenic (As) Superfund site in Vineland, NJ. It also involves unique epidemiologic studies of As and Manganese (Mn)-exposed adults and adolescents residing in Bangladesh as well as an important mechanistic investigation of As-induced epigenetic dysregulation. As in the past, the Columbia University SRP Center includes a balance between biomedical and non-biomedical research. The proposal includes three biomedical research projects:1) Health Effects of As Longitudinal Study (HEALS); 2) Consequences of As and Mn Exposure on Children's Health; and 3) Impact of Nutrition on Arsenic-Induced Epigenetic Dysregulation. The biomedical research is intimately intertwined with three nonbiomedical projects: 4) Arsenic, Iron, Sulfur and Organic Carbon Speciation, and Their Impact on Groundwater Arsenic; 5) Application of Enhanced Mitigation Methods for Groundwater As at US Superfund Sites; and 6) Defining the Sustainable Uses of Low-As Aquifers in Bangladesh. The Projects are supported by four Research Support Core Laboratories: 8) Data Management; 9) Trace Metals; 10) Biogeochemistry; and 11) Hydrogeology. A Research Translation Core (RTC) entitled, "Collaborating with government and the NIEHS SRP Center: As and Mn Exposure in Groundwater" works with several government agencies to help understand and solve their local groundwater problems. Finally, the RTC will work closely with the Community Engagement Core (CEC) entitled "Promoting As Testing and Treatment to Reduce Health Risks for Residents in Maine." The CEC has developed naturally from our past biomedical and geochemical As research in Maine.

该提案是为了响应题为“超级基金危险物质研究和培训计划 (P42)”的 RFA-ES-10-010 而提交的。拟议的工作涉及新泽西州瓦恩兰单个最严重的砷 (As) 超级基金场地的大量工作。它还涉及对居住在孟加拉国的接触砷和锰 (Mn) 的成年人和青少年进行独特的流行病学研究，以及对砷引起的表观遗传失调的重要机制研究。与过去一样，哥伦比亚大学 SRP 中心平衡生物医学和非生物医学研究。该提案包括三个生物医学研究项目：1）健康影响纵向研究（HEALS）； 2) 砷和锰接触对儿童健康的影响； 3) 营养对砷引起的表观遗传失调的影响。生物医学研究与三个非生物医学项目密切相关：4）砷、铁、硫和有机碳形态及其对地下水砷的影响； 5) 对地下水应用强化缓解方法，如美国超级基金所在地； 6) 确定孟加拉国低砷含水层的可持续利用。该项目由四个研究支持核心实验室支持： 8) 数据管理； 9) 微量金属； 10）生物地球化学； 11) 水文地质学。题为“与政府和 NIEHS SRP 中心合作：地下水中砷和锰暴露”的研究翻译核心 (RTC) 与多个政府机构合作，帮助了解和解决当地地下水问题。最后，RTC 将与社区参与核心 (CEC) 密切合作，题为“促进检测和治疗以降低缅因州居民的健康风险”。 CEC 是我们过去在缅因州进行的生物医学和地球化学砷研究的自然发展。