Smartphone-based meditation training to reduce adolescent depression

基于智能手机的冥想训练可减少青少年抑郁

• 批准号: 10664427
• 负责人: Matthew Hirshberg
• 金额: $ 13.5万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-07 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10664427
• 关键词: 3-Dimensional; Address; Adolescence; Adolescent; Adult; Attention; Award; Behavior; Behavior assessment; Behavioral; COVID-19 pandemic; Caring; Cellular Phone; Clinical; Clinical Research; Clinical Trials; Cognitive; Complex; Control Groups; Coupled; Data; Development; Effectiveness; Equation; Funding; Future; Geography; Goals; Grant; Growth; Healthcare; Heart; Heart Rate; Individual Differences; Information Systems; Intercept; Intervention; Intervention Studies; K-Series Research Career Programs; Knowledge; Lead; Loneliness; Major Depressive Disorder; Mediating; Mediation; Mediator; Meditation; Mental Depression; Mental Health; Mental Health Services; Mentors; Methods; Mind; Modeling; Outcome Measure; Participant; Patient Outcomes Assessments; Patient Self-Report; Personal Satisfaction; Persons; Pilot Projects; Population; Positioning Attribute; Prevalence; Prevention; Psychopathology; Psychophysiology; Race; Randomized; Randomized, Controlled Trials; Religion; Reporting; Research; Rest; Safety; Sampling; Sleep; Social isolation; Symptoms; Technology; Testing; Thinking; Training; Translational Research; Treatment Efficacy; United States; United States National Institutes of Health; Waiting Lists; Work; acceptability and feasibility; active control; arm; child depression; cost; depressive symptoms; design; effective therapy; efficacy evaluation; follow-up; frontier; high school; innovation; intervention delivery; mHealth; mindfulness; mobile computing; programs; psychologic; randomized trial; randomized, clinical trials; service providers; skills; skills training; sleep quality; smartphone application; social; virtual; wearable device

Project Summary / Abstract Despite robust evidence that (a) depression rises precipitously during adolescence, (b) mental health during adolescence predicts lifelong trajectories, and (c) meditation-based interventions (MBIs) reduce depressive symptoms, access to and research on MBIs in adolescent populations is limited. Mobile health (mHealth) delivery of MBIs offers the promise of accessibility, affordability, and personalization. Research on mHealth MBIs in adults indicates these programs are feasible, acceptable, safe, and effective in reducing depressive symptoms. Coupled with advances in ambulatory assessment of behavior and psychophysiology (i.e., personal sensing data) through wearable devices, mHealth and personal sensing data represent a new frontier in intervention research and mental health care. Although mHealth technologies are ubiquitous for today’s adolescents, there is virtually no research on mHealth MBIs in adolescents and no research integrating mHealth MBI delivery with personal sensing data. The proposed Career Development Award begins to address this knowledge gap by developing the candidate’s skills to conduct research involving clinical adolescent samples, personal sensing data, and advanced mediation methods to identify mechanisms of change. This new training will be leveraged to study, in a sample of 150 adolescents with elevated depressive symptoms, the impact of a mHealth MBI that has strong preliminary evidence of efficacy. Participants will be randomly assigned to the mHealth MBI or to a wait-list control condition. Aim 1 will assess the feasibility, acceptability, and safety of the 8-week mHealth MBI in depressed adolescents. Aim 2 will preliminarily assess program efficacy in reducing depressive symptoms. Aim 3 will characterize psychological (i.e., perseverative thinking, cognitive distancing, loneliness), behavioral (i.e., social isolation via geolocation data), and psychophysiological (i.e., sleep quality and heart rate metrics via wearable) mediator effects on depressive symptoms using advanced structural equation modeling methods. These methods will provide preliminary evidence of intervention efficacy while potentially identifying mechanisms of change at multiple levels of analysis, providing critical data for planning future, large-scale randomized controlled trials. All aims will be supported by didactic, experiential, and mentored training in the fundamentals of clinical research through the NIH-funded Institute for Clinical and Translational Research (ICTR) and the Center for Healthy Minds. Aim 3 will be facilitated by new training in personal sensing data and advanced mediation methods, supported by a mentor team with extensive expertise in these domains. Combined, the research aims and training goals of this project seek to promote the development of accessible, acceptable, safe, and effective mHealth MBIs for the treatment and ultimately prevention of adolescent depression. This award will enable the candidate to conduct future intervention and mechanism research aimed at reducing the burden of depression in adolescents.

项目概要/摘要 尽管有强有力的证据表明（a）抑郁症在青春期急剧上升，（b）青春期的心理健康状况 青春期预测一生的轨迹，并且（c）基于冥想的干预措施（MBI）减少抑郁 青少年人群中 MBI 的症状、获取和研究有限。 MBI 的交付为移动医疗研究提供了可及性、可负担性和个性化的承诺。 成人 MBI 表明这些计划在减少抑郁方面是可行、可接受、安全且有效的 再加上行为和心理生理学（即个人）动态评估的进步。 传感数据）通过可穿戴设备、移动医疗和个人传感数据代表了一个新领域 尽管移动医疗技术在当今已无处不在。 青少年中，几乎没有关于青少年 mHealth MBI 的研究，也没有整合 MBI 的研究 拟议的职业发展奖开始提供个人传感数据的 mHealth MBI。 通过培养候选人进行涉及临床研究的技能来解决这一知识差距 青少年样本、个人感知数据和先进的中介方法来识别机制 这项新的培训将用于对 150 名患有抑郁症的青少年进行研究。 参与者将了解具有强有力的初步疗效证据的 mHealth MBI 的影响。 目标 1 将评估可行性， 目标 2 将初步评估 8 周 mHealth MBI 在抑郁青少年中的可接受性和安全性。 目标 3 的目标是心理（即坚持不懈）的效果。 思维、认知距离、孤独）、行为（即通过地理位置数据进行的社会隔离）以及 心理生理学（即通过可穿戴设备测量睡眠质量和心率指标）对抑郁的中介效应 使用先进的结构方程建模方法，这些方法将提供初步的症状。 干预效果的证据，同时可能确定多个层面的变化机制 分析，为规划未来的大规模随机对照试验提供关键数据。 通过临床研究基础知识的教学、体验和指导培训来支持 NIH 资助的临床与转化研究所 (ICTR) 和健康思想中心 Aim 3。 将通过个人传感数据和先进调解方法的新培训来促进，并得到 结合了这些领域的广泛专业知识的团队，该研究的目的和培训目标。 该项目致力于促进可访问、可接受、安全和有效的移动医疗 MBI 的开发 该奖项将使候选人能够进行青少年抑郁症的治疗和最终预防。 未来的干预和机制研究旨在减轻青少年抑郁负担。