High Performance Multi-Modality Small Animal Imaging System

高性能多模态小动物成像系统

• 批准号: 8334868
• 负责人: BENJAMIN M. W. TSUI
• 金额: $ 174.9万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-15 至 2015-06-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8334868
• 关键词: 7 year old; Advisory Committees; Anatomy; Anesthesia procedures; Animals; Award; Biochemical Process; Blood; Cadmium; Communities; Electrocardiogram; Equipment; Head; Housing; Image; Injection of therapeutic agent; Institutes; Isotopes; Magnetic Resonance Imaging; Measurement; Medical; Modality; Monitor; Performance; Physiologic Monitoring; Physiologic pulse; Physiology; Policies; Positron-Emission Tomography; Procedures; Pump; Research Institute; Research Personnel; Resolution; Respiration; Small Animal Imaging Systems; Spottings; System; Temperature; Tube; Ultrasonography; United States National Institutes of Health; Visual; Zinc; base; detector; imaging modality; instrumentation; meetings; multimodality; operation; optical imaging; respiratory; single photon emission computed tomography; solid state

DESCRIPTION (provided by applicant): The broad, long-term objective of the NIH High-End Instrumentation Award application is to acquire a new state-of-the-art high-performance small animal (SA) PET/SPECT/CT imaging system for multi-modality imaging of small animals to allow biomedical researcher at Johns Hopkins Medical Institutes (JHMI) to gain unprecedentedly clear and new information on different aspects of the anatomy, physiology, and biochemical processes involved in normal and diseased animals. The specific aims of the proposed acquisition are: (1) to replace the existing over 7-year old and outdated stand-alone small animal (SA) PET and SPECT/CT systems that are currently serving the JHMI research community, and (2) to provide users with an integrated PET/SPECT/CT system that allows accurate registration of the multimodality images. To achieve the aims, we propose to acquire a commercial Gamma Medica (GM) state-of-the-art high-performance integrated multi- modality SA PET/SPECT/CT imaging system based on a single TriumphTM gantry. The GM multimodality SA imaging system consists of four components: (1) a LabPET 12 stationary ring PET subsystem with dual-layer LYSO/LGSO scintilliators integrated with avalanche photodiode (APD) detectors and with 12 cm axial field-of- view, (2) a SPECT subsystem with 2 -head state-of-the-art solid-state cadmium zinc telluride (CZT) detector based camera modules with high-energy resolution that is especially important for multi-isotope imaging, (3) a high-resolution microCT subsystem with tunable x-ray generator and variable micro focal-spot x-ray tube with highest achievable resolution of less than 35 micron and the special pulsed x-ray tube also allow respiratory gated CT studies, and (4) state-of-the-art SA imaging accessories including a physiological monitoring system that simultaneously monitors temperature, ECG and respiration, a anesthesia system, an injection pump, a blood counter and exfusion pump for input function measurements for small animals. The proposed multi- modality SA PET/SPECT/CT system will be housed in the existing Small Animal Imaging Center (SAIC), together with a 9.4T small bore MRI system, a Xenogen IVIS 200 optical imaging system, and a Visual Sonics SA ultrasound imaging system. This combination represents the most complete and state-of-the-art multimodality SA imaging facility. The operation of the proposed equipment will be overseen by an Advisory Committee formed by the PI, the Co-PI and the major users across JHMI. The Advisory Committee will meet twice a year to review the operation of the SA imaging suite and to set policies and procedures to assure equitable use of the proposed equipment.

描述（由申请人提供）：NIH高端仪器奖的申请的广泛，长期目标是获得新的最先进的高性能小动物（SA）PET/SPECT/CT/CT/CT成像系统，用于对小动物进行多模式成像的多模型成像，允许Johns Hopkins Medical Institutes（JHMI）的生物医学研究人员（JHMI）的生物医学研究人员（JHMI）的新信息，并具有新的信息，并具有新的信息。正常动物和患病动物涉及的生化过程。拟议的收购的具体目的是：（1）替换现有的7岁且过时的独立小动物（SA）PET和SPECT/CT系统，目前正在为JHMI研究社区提供服务，（2）为用户提供允许准确注册多态性图像的集成PET/SPECT/CT系统。为了实现目标，我们建议以单个Triumphtm gantry获得商业伽马医学（GM）最先进的高性能综合多态性多模态。 The GM multimodality SA imaging system consists of four components: (1) a LabPET 12 stationary ring PET subsystem with dual-layer LYSO/LGSO scintilliators integrated with avalanche photodiode (APD) detectors and with 12 cm axial field-of- view, (2) a SPECT subsystem with 2 -head state-of-the-art solid-state cadmium zinc telluride (CZT) detector based具有高能量分辨率的摄像头模块对于多相位成像特别重要，（3）具有可调X射线发电机和可变的微型焦点X射线管的高分辨率微分离子系统，可达到最高可实现的X射线管，可最高可实现的分辨率为35 micron，并允许X射线管的X射线访问量少于35 microtie，并允许X射线访问型X射线访问量，并允许使用X射线的ct研究，并（4）图像ct和4）同时监视温度，心电图和呼吸的系统，麻醉系统，注射泵，血液计数器和去灌注泵，用于用于小动物的输入功能测量。所提出的多种模态SA PET/SPECT/CT系统将安置在现有的小动物成像中心（SAIC）中，以及9.4T小孔MRI系统，Xenogen ivis 200光学成像系统和视觉超声SAICS SA超声成像系统。这种组合代表了最完整，最先进的多模式SA成像设施。拟议设备的运行将由PI，Co-Pi和JHMI的主要用户组成的咨询委员会监督。咨询委员会将每年开会两次，以审查SA成像套件的运行，并制定政策和程序，以确保公平使用拟议的设备。