High-Resolution SPECT for Molecular Imaging

用于分子成像的高分辨率 SPECT

• 批准号: 7275971
• 负责人: BENJAMIN M. W. TSUI
• 金额: $ 47.51万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7275971
• 关键词: Animals; Area; Arterial Fatty Streak; Arts; Biomedical Research; Calibration; Cardiovascular Diseases; Characteristics; Collimator; Computer software; Data; Detection; Development; Diagnosis; Diffuse; Ensure; Gamma Cameras; Goals; Head; Human; Image; Imaging Device; Imaging Techniques; Imaging technology; Label; Methods; Modality; Modeling; Modification; Molecular; Morphologic artifacts; Mus; Performance; Radioactivity; Research; Research Personnel; Resolution; Staging; Standards of Weights and Measures; System; Techniques; Technology; Testing; Transgenic Mice; Transgenic Organisms; Translations; annexin A5; attenuation; base; concept; design; detector; image reconstruction; improved; in vivo; innovation; molecular imaging; mouse model; novel; prototype; reconstruction; research study; response; simulation; single photon emission computed tomography; tomography; ultra high resolution

DESCRIPTION (provided by applicant): The long-term goal of this project is to develop an advanced mu/SPECT/CT molecular imaging technology including a state-of-the-art innovative mu/SPECT system and accurate quantitative pinhole and multi-pinhole SPECT imaging techniques that provide ultra-high-resolution down to approximately 0.5 mm and detection efficiency on the order of 2 cps/mu/Ci. To evaluate the novel fSPECT/CT technology, we propose to perform simulations as well as experimental phantom and small animal imaging studies. To respond to the main concern of the reviewers that the previous proposal was too diffuse, we have refocused the research by redesigning the mu/SPECT system configuration with a fixed-angled detector assembly without going through the prototype stage, constructing the unique 'angled detector module assembly' with the latest high performance but robust detector technologies, eliminating the longitudinal tomography study using planar multi-pinhole imaging with standard gamma camera system, deleting two small animal imaging studies to focus on the most important application to imaging of plaques in mice, and switching to a simpler transgenic mouse model with stable and unstable plaques. Also, the proposal is strengthened by additional preliminary data from multi-pinhole image reconstruction, Monte Carlo simulation of pinhole SPECT data, and plaque imaging in transgenic mice using 99mTc Hynic-Annexin V. The team of investigators is streamlined with 2 groups of investigators and 3 key consultants with relevant areas of expertise. The revised specific aims are: (1) to develop a state-of-the-art 'angled' detector module and single and multiple pinhole collimation and an x-ray imaging device for use in the mu/SPECT/CT systems in Aim #5, (2) to develop simulation software for 3D SPECT imaging that models performance characteristics of the scintillation camera modules, design parameters of single and multiple pinhole collimator, and the SPECT system geometry and configuration, (3) to develop 3D quantitative SPECT image reconstruction methods for single and multiple pinhole SPECT with correction of attenuation, scatter and collimator response for accurate absolute quantitation of radioactivity in vivo, (4) to develop simple, accurate and robust calibration methods for single and multi-pinhole SPECT systems, (5) to develop a prototype mu/SPECT/CT system that includes two angled detector assemblies developed in Aim #1 and an existing mu/CT system that will be mounted on a commercial grade CT gantry, and (6) to evaluate the pinhole SPECT imaging techniques and the mu/SPECT/CT system in imaging stable and vulnerable plaques in a transgenic mouse model using 99mTc labeled Annexin-V.

描述（由申请人提供）： 该项目的长期目标是开发先进的MU/SPECT/CT分子成像技术，包括最先进的创新MU/SPECT系统，以及准确的定量针孔和多针孔SPECT成像技术，可提供超高分辨率，可向下降低至大约0.5 mm，并根据2 cps/mu/ci/ci/mu/ci的顺序提高效率。为了评估新颖的fspect/ct技术，我们建议进行模拟以及实验性幻影和小动物成像研究。为了回应审阅者的主要问题，即先前的提案太弥漫着，我们已经通过重新设计MU/Spect System配置，并使用固定角度的探测器组装重新设计了MU/Spect System配置，而无需穿越原型阶段，构建了独特的'Angled detector模块组装，并使用最新的高性能镜头来使用标准的近距离研究，消除了远距离研究，以消除了远程图像，以消除远程图像。系统，删除了两项小型动物成像研究，以关注小鼠斑块成像的最重要应用，并切换到具有稳定且不稳定的斑块的简单转基因小鼠模型。此外，使用99MTC Hynic-Annexin V中的多个针孔图像重建，针孔SPECT数据的蒙特卡洛模拟以及斑孔成像的其他初步数据可以加强该提案。 The revised specific aims are: (1) to develop a state-of-the-art 'angled' detector module and single and multiple pinhole collimation and an x​​-ray imaging device for use in the mu/SPECT/CT systems in Aim #5, (2) to develop simulation software for 3D SPECT imaging that models performance characteristics of the scintillation camera modules, design parameters of single and multiple pinhole collimator, and the SPECT system geometry and配置，（3）为单孔和多个针孔群开发3D定量SPECT图像重建方法，并校正衰减，散射和准直响应，以准确地绝对对体内放射性的绝对定量，（4）开发简单，准确，准确的校准方法，用于开发单个和多蛋白孔系统，以开发一个摩托图，（5），（5）构图，（5）构图，（5），（5）构图，（5）prots prots inter/prots inter/prots inter/prots类型（5） AIM＃1和现有的MU/CT系统将安装在商业级CT龙门上，（6）使用99MTC标记的Annexin-v在转基因小鼠模型中在成像中评估稳定且易于损坏的木材中的针孔Spect Imaging技术和MU/SPECT/CT系统。

项目成果

Recent advances in small-animal cardiovascular imaging.

• DOI: 10.2967/jnumed.108.058479
• 发表时间: 2009-05
• 期刊: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
• 作者: Tsui BM;Kraitchman DL
• 通讯作者: Kraitchman DL

Is iterative reconstruction ready for MDCT?

• DOI: 10.1016/j.jacr.2008.12.014
• 发表时间: 2009-04
• 期刊: JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY
• 影响因子: 4.5
• 作者: Xu, Jingyan;Mahesh, Mahadevappa;Tsui, Benjamin M W
• 通讯作者: Tsui, Benjamin M W

Development and validation of a Monte Carlo simulation tool for multi-pinhole SPECT.

• DOI: 10.1007/s11307-009-0263-7
• 发表时间: 2010-06
• 期刊: MOLECULAR IMAGING AND BIOLOGY
• 影响因子: 3.1
• 作者: Mok, Greta S. P.;Du, Yong;Wang, Yuchuan;Frey, Eric C.;Tsui, Benjamin M. W.
• 通讯作者: Tsui, Benjamin M. W.

The effects of object activity distribution on multiplexing multi-pinhole SPECT.

物体活动分布对多针孔 SPECT 的影响。

• DOI: 10.1088/0031-9155/56/8/019
• 发表时间: 2011-04-21
• 期刊: Physics in medicine and biology
• 影响因子: 3.5
• 作者: Mok GS;Tsui BM;Beekman FJ
• 通讯作者: Beekman FJ