High Resolution SPECT-MR for Molecular Imaging

用于分子成像的高分辨率 SPECT-MR

• 批准号: 7652860
• 负责人: BENJAMIN M. W. TSUI
• 金额: $ 56.87万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7652860
• 关键词: Affect; Animals; Applications Grants; Arts; Beds; Biochemical; Birds; Brain; Cadmium; Characteristics; Clinical; Collimator; Computer software; Data; Detection; Development; Diagnosis; Disease; Engineering; Evaluation; Goals; Housing; Human; Image; Magnetic Resonance Imaging; Manufacturer Name; Methods; Molecular; Morphologic artifacts; Mus; Neurotransmitter Receptor; Performance; Photons; Physiologic pulse; Process; RF coil; Radiology Specialty; Rattus; Research; Research Personnel; Research Project Grants; Resolution; Site; Source; Sum; Surface; System; Techniques; Testing; Universities; Work; Zinc; aging population; base; bioimaging; cadmium telluride; clinical application; computer generated; cost; data acquisition; design; design and construction; detector; image processing; image reconstruction; imaging modality; improved; innovation; instrumentation; magnetic field; millimeter; molecular imaging; multimodality; nervous system disorder; pre-clinical; programs; prototype; research study; simulation; single photon emission computed tomography; software development; tool

In this 2-year AARA grant application, we propose to develop, construct, and evaluate a prototype SPECT/MRI system for simultaneous high-resolution molecular SPECT/MR imaging of small animals, with the potential of further developing into a human brain SPECT/MRI system. The main innovations include the use of state-of-the-art MR compatible cadmium zinc telluride (CZT) detector modules developed by our industrial partner, Gamma Medica-Ideas (GMI). The new CZT detectors have small sub-millimeter resolvable pixel size that allows acquisition of high-resolution SPECT projection data. A ring-type SPECT subunit will be developed based on five CZT based cameras each consists of a 5x5 array of 2.54cmx2.54cm CZT detector modules. The cameras will connected seamlessly to form a ring SPECT subunit that will fit inside a 3T Philips MRI system allowing high-resolution SPECT imaging for small animals as well as potential development of a human brain SPECT/MRI system, for simultaneous acquisition of SPECT/MRI data. A cylindrical collimator with an array of multi-pinhole apertures that surrounds the small animal will be developed and a birdcage RF coil will be designed and constructed that is attached to the inside surface of the collimator cylinder. Multi-pinhole images of the small animal are projected onto the contiguous detector surface. Also, shimming methods, quantitative multi-pinhole SPECT image reconstruction methods, optimized MR pulse sequences and image fusion methods will be developed for artifact-free co-registered SPECT/MR images. The Johns Hopkins University (JHU) team of investigators comprises strong expertise in high-resolution SPECT instrumentation, simulation tools and quantitative image reconstruction methods and in MR imaging including RF coil design, shimming for magnetic field uniformity, MR pulse sequences, MR data acquisition methods and image reconstruction and processing methods. The proposed research will involve (1) development of high-resolution MR compatible CZT detectors for SPECT imaging, (2) development of optimized RF transmit/receive coils, shimming methods and MRI pulse sequences for artifact-free high-resolution small animal MR imaging using the Philips 3T MRI system in the presence of the SPECT subunit, (3) development of an optimized MR compatible SPECT subunit and image reconstruction methods for artifact-free SPECT images inside the 3T MRI system, and (4) preliminary evaluation of the SPECT/MR system using physical phantom and simulation studies.

在这项为期两年的AARA赠款应用中，我们建议开发，构建和评估小动物的同时高分辨率分子SPECT/MR成像的原型SPECT/MRI系统，并有可能进一步发展为人脑Spect/Spect/spect/spect/ MRI系统。主要的创新包括使用最先进的MR兼容镉易尿酸锌（CZT）检测器模块由我们的工业合作伙伴Gamma Medica-Ideas（GMI）开发。新的CZT探测器具有较小的亚毫米可分离的像素大小，可以获取高分辨率SPECT投影数据。将基于五个基于CZT的摄像机开发一个环形SPECT亚基，每个相机由2.54cmx2.54cm CZT检测器模块组成的5x5阵列。相机将无缝连接以形成一个环形频谱亚基，该子弹簧亚基适合3T飞利浦MRI系统，允许对小动物进行高分辨率SPECT成像以及人脑光谱/MRI系统的潜在发展，以同时获得SPECT/MRI数据。将开发一个带有围绕小动物的多针孔孔的圆柱准直仪，并将设计和构造一个鸟笼RF线圈。小动物的多针孔图像被投影到连续的探测器表面上。此外，将开发用于无伪影共同注册的SPECT/MR图像的光滑方法，定量多针SPECT图像重建方法，优化的MR脉冲序列和图像融合方法。约翰·霍普金斯大学（JHU）调查人员团队包括高分辨率光谱仪器，仿真工具和定量图像重建方法的强大专业知识，以及包括RF线圈设计，磁场均匀性，MR PULSE序列，MR PULSE序列，MR数据采集方法的MR成像中的专业知识以及图像重建和处理方法。拟议的研究将涉及（1）开发用于SPECT成像的高分辨率MR兼容CZT检测器，（2）开发优化的RF发射/接收线圈，旋转方法和MRI脉冲序列，用于无伪影高分辨率的高分辨率小动物MR成像在SPECT亚基的存在下使用Philips 3T MRI系统，（3）开发了优化的MR兼容SPECT亚基和图像重建方法，用于3T MRI系统内的无伪影SPECT图像，以及（4）SPECT的初步评估/MR系统使用物理幻影和仿真研究。