The Influence of Aerobic Exercise on Cognitive Functioning in Schizophrenia

有氧运动对精神分裂症认知功能的影响

• 批准号: 8441470
• 负责人: DAVID KIMHY
• 金额: $ 19.2万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-08 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8441470
• 关键词: Academic Medical Centers; Address; Adolescent; Adult; Aerobic; Aerobic Exercise; Antipsychotic Agents; Attention; Behavior Therapy; Clinical Trials; Cognition; Cognitive; Cognitive deficits; Cognitive remediation; Control Groups; Counseling; Data; Development; Elderly; Female; Generations; Hippocampus (Brain); Hour; Human; Impaired cognition; Impairment; Incidence; Individual; Intervention; Investments; Lead; Life Style; Link; Literature; Medical center; Memory; Meta-Analysis; Neurocognitive; New York City; Outpatients; Participant; Patients; Physiological; Population; Public Health; Publishing; Randomized; Randomized Clinical Trials; Reporting; Research; Schizophrenia; Severities; Short-Term Memory; Signal Transduction; Symptoms; Time; Training; Training Programs; Verbal Learning; animal data; base; behavior measurement; blind; cognitive function; daily functioning; disability; executive function; fitness; follow-up; functional disability; functional outcomes; improved; improved functioning; interest; male; memory process; novel; processing speed; programs; sedentary; social cognition; treatment as usual; visual learning; young adult

DESCRIPTION (provided by applicant): Schizophrenia has a population incidence of 1%, but it is the 9th leading cause of disability worldwide. Individuals with schizophrenia display a broad range of cognitive deficits that have been identified as major determinants of poor daily functioning and disability, thus representing a serious public health concern. Current pharmacological and cognitive remediation treatments offer limited to modest efficacy in improving these deficits. However, data from animal and human research strongly support the positive influence of Aerobic Exercise (AE) on cognitive functioning. As individuals with schizophrenia typically display cognitive deficits along with a highly sedentary lifestyle, and preliminary evidence suggest that AE training is both feasible and effective in increasing aerobic fitness in this population, it is reasonable to hypothesize that AE may also improve cognitive functioning. However, this association has hardly been investigated in schizophrenia. To elucidate this putative link, we propose to evaluate the influence of AE on cognitive functioning in schizophrenia using a single-blind, randomized clinical trial. Outpatient individuals with schizophrenia (n=48) receiving treatment at a large academic medical center in New York City will be randomly assigned to Aerobic Exercise (AE) training or Treatment As Usual (TAU). Participants in the AE training will undergo a 12-week, 3 times per week, 1-hour AE sessions at the medical center. All patients will receive appropriate pharmacological and counseling treatment. Assessments of neurocognitive and daily functioning abilities, along with symptom severity, and physiological and behavioral measures of aerobic fitness will be completed before and after the 12-week program by raters blind to treatment status. This study will allow determining the putative positive influence of AE on cognitive and daily functioning in individuals with schizophrenia.

描述（由申请人提供）：精神分裂症的人口发病率为1％，但它是全球残疾人的第9个主要原因。精神分裂症患者表现出广泛的认知缺陷，这些缺陷已被确定为日常功能和残疾差的主要决定因素，从而代表了严重的公共健康问题。当前的药理和认知补救治疗可用于改善这些缺陷的适度功效。但是，来自动物和人类研究的数据强烈支持有氧运动（AE）对认知功能的积极影响。由于精神分裂症患者通常会表现出认知缺陷以及高度久坐的生活方式，并且初步证据表明，AE训练在增加该人群中有氧健身方面既可行又有效，因此假设AE也可以提高认知功能是合理的。但是，在精神分裂症中几乎没有研究这种关联。为了阐明这种推定的联系，我们建议使用单盲，随机的临床试验评估AE对精神分裂症认知功能的影响。精神分裂症患者（n = 48）在纽约市的一个大型学术医疗中心接受治疗的患者将像往常一样被随机分配到有氧运动（AE）培训或治疗中（TAU）。 AE培训的参与者将在医疗中心接受12周，每周3次，1小时的AE会议。所有患者将获得适当的药理和咨询治疗。对神经认知和日常功能的评估以及症状严重程度以及有氧健身的生理和行为度量将在为期12周的计划之前和之后由对治疗状况视而不见的12周计划。这项研究将允许确定AE对精神分裂症患者认知和日常功能的推定积极影响。

项目成果

Aerobic Exercise in People with Schizophrenia: Neural and Neurocognitive Benefits.

• DOI: 10.1007/s40473-016-0077-2
• 发表时间: 2016-06
• 期刊: Current behavioral neuroscience reports
• 影响因子: 1.7

Enhancement of aerobic fitness improves social functioning in individuals with schizophrenia.

• DOI: 10.1007/s00406-020-01220-0
• 发表时间: 2021-03
• 期刊: European archives of psychiatry and clinical neuroscience
• 影响因子: 4.7
• 作者: Kimhy D;Tay C;Vakhrusheva J;Beck-Felts K;Ospina LH;Ifrah C;Parvaz M;Gross JJ;Bartels MN
• 通讯作者: Bartels MN

Inflammation in individuals with schizophrenia - Implications for neurocognition and daily function.

• DOI: 10.1016/j.bbi.2018.09.016
• 发表时间: 2018-11
• 期刊: Brain, behavior, and immunity
• 作者: Kogan S;Ospina LH;Kimhy D
• 通讯作者: Kimhy D