Psychosis in Schizophrenia: Mechanisms of Recovery

精神分裂症的精神病：恢复机制

基本信息

批准号：
8063528
负责人：
DAVID KIMHY
金额：
$ 17.73万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-05-17 至 2013-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8063528
关键词：
Aftercare Age Antipsychotic Agents Area Arousal Basic Science Cardiac Clinical Clinical Research Cognitive Cognitive Therapy Computers Data Data Analyses Delusions Drug usage Environment Etiology Goals Hallucinations Handheld Computers Hour In Situ Instruction Intervention Knowledge Linear Models Link Measures Mediating Mentored Patient-Oriented Research Career Development Award Mentorship Methodology Methods Neurobiology Outpatients Patients Pharmacological Treatment Physiological Play Population Process Psychotic Disorders Randomized Recovery Regulation Research Research Personnel Research Training Resources Role Sampling Schizophrenia Severities Stress Supervision Symptoms System Time Training Translating Universities base career coping daily functioning design experience follow-up heart rate variability improved in vivo interest medication compliance negative mood neurobiological mechanism patient oriented programs psychologic sex stressor treatment as usual

项目摘要

DESCRIPTION (provided by applicant): In this revised application for a Mentored Patient-Oriented Research Career Development Award (K23), Dr. David Kimhy will pursue training and research in the cognitive and neurobiological mechanisms of stress regulation and psychosis in schizophrenia. The goals of the training and research plan are integrated around the hypothesis that cognitive coping strategies mediate the link between stress and psychotic symptoms during recovery from psychosis in schizophrenia. Under the sponsorship of Dr. Dolores Malaspina, the training plan capitalizes on the resources of NYSPI/Columbia University, combining formal coursework, direct supervision, and clinical research experience and training. The plan involves mentorship and didactic instruction in key areas including: 1) psychosis research in schizophrenia using of Experience Sampling Method (ESM), 2) clinical methodologies for assessment of stress-regulating systems, 3) data analysis using multilevel linear modeling, and 4) cognitive-behavior therapy for psychosis (CBTp). Current methodologies have limited ecological validity to establish causal links between momentary changes in stress and psychosis. Dr. Kimhy will study simultaneously the real-time physiological and psychological correlates of psychosis using ambulatory assessment of cardiac autonomic regulation (Heart Rate Variability; HRV) synchronized with data collected using Experience Sampling Method (ESM) with Palm handheld computers. The research plan involves simultaneous probing of momentary psychotic symptoms, subjective stress, HRV, and cognitive coping strategies. Assessments will be conducted before and after pharmacological and CBTp treatments of psychosis. This methodology translates basic science into use in real-time, real-world environments (in-vivo and in-situ), allowing for the assessment of psychosis as part of the ebb-and-flow of daily functioning. Understanding these interactions will advance our understanding of the mechanisms of recovery from psychosis in schizophrenia. The proposed training and research plan will provide Dr. Kimhy with the knowledge, training, and experience necessary to develop as an independent researcher focusing on the neurobiological and psychological mechanisms of stress regulation and psychosis in schizophrenia.

描述（由申请人提供）：在这项经过修订的申请中，戴维·金希（David Kimhy）博士将在精神分裂症的认知和神经生物学机制上进行认知和神经生物学机制的培训和研究。培训和研究计划的目标是围绕以下假设的，即认知应对策略介导了精神分裂症精神病中恢复精神病期间压力与精神病症状之间的联系。在培训计划Dolores Malaspina博士的赞助下，培训计划利用了NYSPI/哥伦比亚大学的资源，结合了正式的课程，直接监督以及临床研究经验和培训。该计划涉及关键领域的指导和教学指导，包括：1）使用经验抽样方法（ESM）的精神分裂症研究（ESM），2）用于评估压力调节系统的临床方法论，3）使用多层线性建模的数据分析，以及4）4）认知行为治疗精神病（CBTP）。当前的方法论的生态有效性有限，可以在压力和精神病的瞬时变化之间建立因果关系。 Kimhy博士将使用心理自主调节（心率变异性； HRV）与使用经验抽样方法（ESM）与棕榈手持计算机同步的数据同步，同时研究精神病的实时生理和心理相关性。该研究计划涉及瞬时精神病症状，主观压力，HRV和认知应对策略。评估将在药理和CBTP治疗精神病之前和之后进行。该方法将基础科学转化为实时的现实环境（体内和原位），从而可以评估精神病，这是日常运作的潮起潮落的一部分。了解这些相互作用将使我们对精神分裂症精神病的恢复机制的理解。拟议的培训和研究计划将为Kimhy博士提供作为独立研究人员所必需的知识，培训和经验，专注于精神分裂症的压力调节和精神病的神经生物学和心理学机制。

项目成果

期刊论文数量（14）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Depressed mood in individuals with schizophrenia: A comparison of retrospective and real-time measures.

DOI：
10.1016/j.psychres.2015.03.008
发表时间：
2015-06-30
期刊：
PSYCHIATRY RESEARCH
影响因子：
11.3
作者：
Blum, Lisa H.;Vakhrusheva, Julia;Saperstein, Alice;Khan, Samira;Chang, Rachel W.;Hansen, Marie C.;Zemon, Vance;Kimhy, David
通讯作者：
Kimhy, David

Emotion awareness and regulation in individuals with schizophrenia: Implications for social functioning.

DOI：
10.1016/j.psychres.2012.05.029
发表时间：
2012-12-30
期刊：
PSYCHIATRY RESEARCH
影响因子：
11.3
作者：
Kimhy, David;Vakhrusheva, Julia;Jobson-Ahmed, Lauren;Tarrier, Nicholas;Malaspina, Dolores;Gross, James J.
通讯作者：
Gross, James J.

Use of mobile assessment technologies in inpatient psychiatric settings.