Neurocognition After Perturbed Sleep (NAPS)

睡眠障碍后的神经认知 (NAPS)

基本信息

批准号：
10425406
负责人：
DAVID KIMHY
金额：
$ 25.35万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-06-09 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10425406
关键词：
Address Affective Animal Experimentation Architecture Biological Markers Blood specimen Cellular Phone Characteristics Chronic Clinical Clinical Research Clinical Trials Cognitive Data Development Diagnosis Electroencephalography Electrophysiology (science)Evaluation Future Goals Home Hour Impairment Individual Infrastructure Intervention Intervention Studies Link Literature Memory Methods Modeling Moods Nature Neurocognition Neurocognitive Neurocognitive Deficit Participant Patient Self-Report Patients Persons Pharmaceutical Preparations Play Polysomnography Population Prevalence Public Health Reporting Role Sampling Schedule Schizophrenia Sleep Sleep Architecture Sleep Disorders Sleep disturbances Sleeplessness Slow-Wave Sleep Social Functioning Symptoms Task Performances actigraphy clinical effect clinically significant cognitive function daily functioning density design diaries disability early psychosis emotion regulation experience experimental study indexing memory consolidation mood symptom neurocognitive test pre-clinical research psychotic symptoms side effect sleep spindle therapy development

项目摘要

Project Summary: The goal of this study is to investigate the impact of sleep on neurocognitive and daily functioning in people with schizophrenia (SZ). Individuals with SZ display a broad range of neurocognitive impairments that have been identified as major determinants of poor functioning and disability, thus representing an important public health concern and a focal target for interventions. Extensive animal, preclinical and clinical research literatures converge in highlighting the critical role insomnia and sleep disturbances play in degrading neurocognitive functioning. Such sleep disturbances, which have been linked to reduced slow wave sleep oscillations and thalamo- cortical sleep spindles, result in clinical presentations that are in line with the neurocognitive difficulties commonly observed in people with SZ. Consistent with these findings, insomnia and sleep disturbances are highly prevalent in people with SZ. However, despite their chronic and ubiquitous nature, there are scant data on the impact sleep disturbances on neurocognition in SZ and there are no data quantifying their influence on daily functioning. Thus, sleep disturbances remain poorly understood and modeled in SZ, their impact is rarely considered in clinical trials, and they remain largely unaddressed by clinicians. To address this gap in the literature, the primary aim of this study is to characterize sleep in individuals with SZ and quantify its impact on neurocognition and daily functioning. Employing an experimental, within-person, repeated assessment design, we will characterize sleep architecture, duration, and quality along with cognitive, electrophysiological, biomarkers and daily functioning sequalae in 40 individuals with SZ. Participants will first complete a week-long, in-home characterization of sleep duration and quality using actigraphy and a sleep diary. Next, they will complete two overnight polysomnography examinations employing two sleep schedules: 1) undisturbed sleep; and 2) restricted sleep (4 hours). As part of these assessments, participants will provide blood samples for biomarkers analyses and complete EEG-indexed memory tasks pre- and post-sleep, along with a post-sleep battery of neurocognitive functioning. Finally, participants will complete a 36- hour ambulatory assessment using actigraphy and smartphones employing Experience Sampling Method (ESM) to explore the impact of sleep on “real-world” daily functioning including symptoms, emotion regulation, and mood. PublicHealth Relevance Statement:This study will provide experimental characterization of the links between sleep neurocognition and functioning in individuals with SZ, informing the development of treatments of neurocognitive deficits in SZ.

项目概括：这项研究的目的是研究睡眠对神经认知和日常功能的影响患有SZ的人表现出广泛的神经认知被确定为功能不良和残疾的主要决定者的损害，因此代表了重要的公共卫生问题和干预措施的重点目标。广泛的动物，临床前和临床研究文献融合着关键角色失眠和睡眠障碍在降解神经认知功能方面发挥了作用。这样的睡眠干扰与减少慢波睡眠振荡和丘脑 - 皮质睡眠纺锤体，导致临床表现与神经认知一致 SZ患者通常会发现困难。与这些发现，失眠和 SZ患者的睡眠障碍非常普遍。但是，做他们的慢性无处不在的性质，有很少的有关SZ神经认知影响睡眠障碍的数据并且没有数据量化它们对日常功能的影响。那，睡眠障碍在SZ中保持不明的理解和建模，在临床试验中很少考虑其影响，而且他们在很大程度上被临床医生所不满足。为了解决文献中的这一差距，这项研究的主要目的是表征SZ患者的睡眠，并量化其对神经认知和日常功能。采用实验，人身重复评估设计，我们将表征睡眠体系结构，持续时间和质量以及 40名患者的认知，电生理，生物标志物和日常功能 SZ。参与者将首先完成一个为期一周的睡眠期间，并质量使用行为学和睡眠日记。接下来，他们将在一夜之间完成两个使用两种睡眠时间表的多个仪表检查：1）未受干扰的睡眠；和2）限制睡眠（4小时）。作为这些评估的一部分，参与者将提供血液样本为了进行生物标志物分析并完整的EEG索引记忆任务前后，带有神经认知功能的囊后电池。最后，参与者将完成36- 使用Actiography和智能手机采用经验取样的小时门诊评估方法（ESM）探讨睡眠对“现实世界”日常功能的影响，包括症状，情绪调节和情绪。 Publichealth相关性声明：本研究将提供实验表征 SZ患者的睡眠神经认知与功能之间的联系，告知 SZ神经认知缺陷的治疗方法的发展。